Published in Cancer Cell on January 01, 2005
MicroRNAs--the micro steering wheel of tumour metastases. Nat Rev Cancer (2009) 5.47
MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell (2010) 3.18
Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol (2006) 2.21
The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell (2007) 2.05
The RB-E2F1 pathway regulates autophagy. Cancer Res (2010) 1.90
Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas. Gynecol Oncol (2011) 1.87
Movers and shakers: cell cytoskeleton in cancer metastasis. Br J Pharmacol (2014) 1.74
Systematic analysis of the transcriptional switch inducing migration of border cells. Dev Cell (2006) 1.63
Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell (2008) 1.62
Retracted STMN-1 is a potential marker of lymph node metastasis in distal esophageal adenocarcinomas and silencing its expression can reverse malignant phenotype of tumor cells. BMC Cancer (2014) 1.54
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J Clin Invest (2010) 1.50
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proc Natl Acad Sci U S A (2009) 1.46
The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition. Mol Cell Biol (2009) 1.43
Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med (2010) 1.43
Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nat Neurosci (2011) 1.29
Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. Int J Cancer (2008) 1.15
Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules. Proc Natl Acad Sci U S A (2011) 1.14
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell (2007) 1.13
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10
p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol (2010) 1.08
Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo. Cell Cycle (2014) 1.07
Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner. Oncotarget (2014) 1.07
Role of T198 modification in the regulation of p27(Kip1) protein stability and function. PLoS One (2011) 1.04
A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis. Am J Gastroenterol (2009) 1.03
Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process. J Biol Chem (2009) 1.03
MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion. Neuro Oncol (2012) 1.02
Differential proteomic analysis of a highly metastatic variant of human breast cancer cells using two-dimensional differential gel electrophoresis. J Cancer Res Clin Oncol (2010) 1.02
Stathmin1 regulates p27 expression, proliferation and drug resistance, resulting in poor clinical prognosis in cholangiocarcinoma. Cancer Sci (2014) 1.01
Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. Nat Commun (2014) 1.01
Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer. Oncogene (2009) 0.99
Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors. Cell Cycle (2015) 0.98
Novel role of stathmin in microtubule-dependent control of endothelial permeability. FASEB J (2012) 0.97
New light on p27(kip1) in breast cancer. Cell Cycle (2012) 0.96
p27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability. Proc Natl Acad Sci U S A (2015) 0.93
Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression. Cancer Res (2007) 0.92
2D difference gel electrophoresis analysis of different time points during the course of neoplastic transformation of human mammary epithelial cells. J Proteome Res (2010) 0.89
Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells. Mol Biol Cell (2006) 0.89
Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer. PLoS One (2012) 0.89
Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis. Oncogene (2013) 0.88
Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders. Genes Cells (2013) 0.87
The molecular basis of wound healing processes induced by lithospermi radix: a proteomics and biochemical analysis. Evid Based Complement Alternat Med (2012) 0.87
MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer. Clin Exp Metastasis (2015) 0.86
Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration. J Cell Sci (2014) 0.86
KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice. J Clin Invest (2008) 0.86
The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer. Br J Cancer (2014) 0.85
Drosophila stathmins bind tubulin heterodimers with high and variable stoichiometries. J Biol Chem (2010) 0.85
DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. Int J Oncol (2013) 0.85
Stathmin is dispensable for tumor onset in mice. PLoS One (2012) 0.84
miR-221 facilitates the TGFbeta1-induced epithelial-mesenchymal transition in human bladder cancer cells by targeting STMN1. BMC Urol (2015) 0.84
Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cells. Cancer Res (2008) 0.83
A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation. Oncogene (2011) 0.83
Effect of leptin on mouse trophoblast giant cells. Biol Reprod (2008) 0.83
Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer. Asian J Androl (2014) 0.83
Brachyury regulates proliferation of cancer cells via a p27Kip1-dependent pathway. Oncotarget (2014) 0.82
EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells. Cell Death Dis (2013) 0.82
Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy. Oncotarget (2014) 0.82
Human pheochromocytomas show reduced p27Kip1 expression that is not associated with somatic gene mutations and rarely with deletions. Virchows Arch (2007) 0.82
Gene expression profiles in mouse embryo fibroblasts lacking stathmin, a microtubule regulatory protein, reveal changes in the expression of genes contributing to cell motility. BMC Genomics (2009) 0.81
CXCR4-independent rescue of the myeloproliferative defect of the Gata1low myelofibrosis mouse model by Aplidin. J Cell Physiol (2010) 0.81
Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility. J Biol Chem (2011) 0.81
Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1. Neural Dev (2009) 0.81
Novel indolyl-chalcones target stathmin to induce cancer cell death. Cell Cycle (2016) 0.80
Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor. BMC Cancer (2014) 0.79
A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition. Biochem J (2014) 0.78
Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes. Sci Rep (2015) 0.78
Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells. World J Gastroenterol (2012) 0.78
The non-canonical functions of p27(Kip1) in normal and tumor biology. Cell Cycle (2016) 0.78
Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration. Oncogene (2016) 0.78
The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis. Cell Death Dis (2014) 0.76
SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status. Cell Cycle (2015) 0.75
p27kip1 expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms. Oncotarget (2016) 0.75
p27(Kip1) promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. Elife (2017) 0.75
p27kip1: An all-round tumor suppressor. Mol Cell Oncol (2016) 0.75
Integrating mechanisms of response and resistance against the tubulin binding agent Eribulin in preclinical models of osteosarcoma. Oncotarget (2016) 0.75
p27 modulates tropism of mesenchymal stem cells toward brain tumors. Exp Ther Med (2010) 0.75
Roles of CDKN1B in cancer? Aging (Albany NY) (2015) 0.75
Stathmin 1 promotes the proliferation and malignant transformation of pancreatic intraductal papillary mucinous neoplasms. Oncol Lett (2017) 0.75
SEPTIN2 and STATHMIN Regulate CD99-Mediated Cellular Differentiation in Hodgkin's Lymphoma. PLoS One (2015) 0.75
p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. Cancer Res (2016) 0.75
p27(Kip1) and STMN1: partners again? Cell Cycle (2014) 0.75
Sphingomyelin Synthase 1 Regulates Neuro-2a Cell Proliferation and Cell Cycle Progression Through Modulation of p27 Expression and Akt Signaling. Mol Neurobiol (2014) 0.75
Meet me in the cytoplasm: A role for p27(Kip1) in the control of H-Ras. Small GTPases (2016) 0.75
Fluoro-edenite induces fibulin-3 overexpression in non-malignant human mesothelial cells. Oncol Lett (2016) 0.75
Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene (2016) 0.75
Predictive value of stathmin-1 and osteopontin expression for taxan resistance in metastatic castrate-resistant prostate cancer. Pak J Med Sci (2017) 0.75
Decrease in stathmin expression by arsenic trioxide inhibits the proliferation and invasion of osteosarcoma cells via the MAPK signal pathway. Oncol Lett (2017) 0.75
PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer. Oncogene (2016) 0.75
FoxR2 promotes glioma proliferation by suppression of the p27 pathway. Oncotarget (2017) 0.75
A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09
E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell (2008) 7.56
A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A (2008) 7.14
Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA (2011) 3.16
Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res (2008) 3.01
Reprogramming of miRNA networks in cancer and leukemia. Genome Res (2010) 2.65
[18F]fluorocholine PET/CT imaging for the detection of recurrent prostate cancer at PSA relapse: experience in 100 consecutive patients. Eur J Nucl Med Mol Imaging (2006) 2.63
Local excision after preoperative chemoradiotherapy for rectal cancer: results of a multicenter phase II clinical trial. Dis Colon Rectum (2013) 2.52
microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood (2010) 2.25
SnapShot: MicroRNAs in Cancer. Cell (2009) 2.10
The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol (2003) 1.97
MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS One (2009) 1.97
MicroRNAs and cancer--new paradigms in molecular oncology. Curr Opin Cell Biol (2009) 1.96
Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer. Cancer Res (2006) 1.71
Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell (2008) 1.62
Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features. Clin Cancer Res (2010) 1.62
Clinical presentation and outcome of colorectal cancer in HIV-positive patients: a clinical case-control study. Onkologie (2009) 1.58
Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex. Cancer Res (2006) 1.46
A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis. Proc Natl Acad Sci U S A (2013) 1.44
The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition. Mol Cell Biol (2009) 1.43
Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer. PLoS One (2013) 1.43
EMILIN-1 deficiency induces elastogenesis and vascular cell defects. Mol Cell Biol (2004) 1.41
Feasibility and diagnostic agreement in teledermatopathology using a virtual slide system. Hum Pathol (2007) 1.39
Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology (2012) 1.38
Association of Wwox with ErbB4 in breast cancer. Cancer Res (2007) 1.37
Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding. Clin Cancer Res (2008) 1.34
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res (2003) 1.32
Extracellular matrix: a matter of life and death. Connect Tissue Res (2008) 1.28
Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. Blood (2010) 1.27
Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization. J Cell Physiol (2008) 1.26
Non-codingRNA sequence variations in human chronic lymphocytic leukemia and colorectal cancer. Carcinogenesis (2009) 1.23
Distribution of PG-M/versican variants in human tissues and de novo expression of isoform V3 upon endothelial cell activation, migration, and neoangiogenesis in vitro. J Biol Chem (2002) 1.22
Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. Clin Cancer Res (2009) 1.22
Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling. J Biol Chem (2011) 1.21
Food groups and risk of non-Hodgkin lymphoma: a multicenter, case-control study in Italy. Int J Cancer (2006) 1.21
Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma. Mol Cell Biol (2003) 1.20
Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters. Oncogene (2004) 1.18
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene (2002) 1.17
p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis. Mol Cancer Ther (2008) 1.16
Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding. Proc Natl Acad Sci U S A (2003) 1.14
Emilin1 deficiency causes structural and functional defects of lymphatic vasculature. Mol Cell Biol (2008) 1.14
Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties. Sci Rep (2013) 1.13
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell (2007) 1.13
The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. Am J Pathol (2010) 1.13
beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain. J Biol Chem (2002) 1.11
Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A. J Biol Chem (2012) 1.09
Protein pathway biomarker analysis of human cancer reveals requirement for upfront cellular-enrichment processing. Lab Invest (2010) 1.09
Breast metastasis of primary colon cancer with micrometastasis in the axillary sentinel node: a metastasis that metastasized? Diagn Pathol (2011) 1.09
p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol (2010) 1.08
Long-term outcome of patients with complete pathologic response after neoadjuvant chemoradiation for cT3 rectal cancer: implications for local excision surgical strategies. Ann Surg Oncol (2011) 1.08
Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. Am J Pathol (2009) 1.08
Hyaluronan-CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9. J Cell Biol (2002) 1.08
Clinical and dermoscopic features of porokeratosis of Mibelli. Arch Dermatol (2009) 1.08
Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo. Cell Cycle (2014) 1.07
Nuclear translocation of insulin receptor substrate-1 by oncogenes and Igf-I. Effect on ribosomal RNA synthesis. J Biol Chem (2002) 1.07
Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner. Oncotarget (2014) 1.07
Risk factors for ovarian cancer histotypes. Eur J Cancer (2007) 1.06
Regression of upper gastric cancer in mice by FHIT gene delivery. FASEB J (2003) 1.06
EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation. J Cell Biol (2011) 1.05
Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2. Mol Cell Biol (2007) 1.05
Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer. Cancer Res (2005) 1.04
Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions. Int J Cancer (2008) 1.04
Antiproliferative and apoptotic effects of two new gold(III) methylsarcosinedithiocarbamate derivatives on human acute myeloid leukemia cells in vitro. Anticancer Drugs (2007) 1.04
Role of T198 modification in the regulation of p27(Kip1) protein stability and function. PLoS One (2011) 1.04
H(2)O(2) induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell line. J Cell Physiol (2002) 1.02
Renal cell cancer and body size at different ages: an Italian multicenter case-control study. Am J Epidemiol (2007) 1.01
The globular domains of PG-M/versican modulate the proliferation-apoptosis equilibrium and invasive capabilities of tumor cells. FASEB J (2004) 1.01
Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo. Carcinogenesis (2004) 1.00
Reproductive, menstrual, and other hormone-related factors and risk of renal cell cancer. Int J Cancer (2008) 1.00
p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice. Cancer Res (2003) 0.99