Published in Am J Physiol Endocrinol Metab on January 18, 2005
The calcium-sensing receptor and calcimimetics in blood pressure modulation. Br J Pharmacol (2011) 1.01
Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice. Br J Cancer (2007) 0.92
Stimulation of calcium-sensing receptors induces endothelium-dependent vasorelaxations via nitric oxide production and activation of IKCa channels. Vascul Pharmacol (2016) 0.80
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature (2005) 5.54
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat Med (2007) 4.22
Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke (2010) 3.75
Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol (2003) 3.10
Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor. N Engl J Med (2004) 2.98
The prevalence of PIK3CA mutations in gastric and colon cancer. Eur J Cancer (2005) 2.83
A central role for free heme in the pathogenesis of severe sepsis. Sci Transl Med (2010) 2.54
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol (2011) 2.37
Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab (2008) 2.30
Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc Natl Acad Sci U S A (2009) 2.11
Parental occurrence of stroke and risk of stroke in their children: the Framingham study. Circulation (2010) 2.07
Physiology and pathophysiology of the calcium-sensing receptor in the kidney. Am J Physiol Renal Physiol (2009) 2.02
Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab (2007) 1.96
Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status. Hum Mol Genet (2004) 1.66
Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol (2012) 1.59
Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res (2007) 1.56
Activating autoantibodies against the calcium-sensing receptor detected in two patients with autoimmune polyendocrine syndrome type 1. J Clin Endocrinol Metab (2009) 1.55
Association of interleukin-4 and interleukin-1 receptor antagonist gene polymorphisms and risk of benign prostatic hyperplasia. Urology (2008) 1.54
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. Hum Mol Genet (2010) 1.53
Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites. Hum Mol Genet (2012) 1.51
Plasma lipids and osteoporosis in postmenopausal women. Endocr J (2002) 1.51
Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease. J Infect Dis (2008) 1.49
The calcium-sensing receptor in normal physiology and pathophysiology: a review. Crit Rev Clin Lab Sci (2005) 1.48
Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke (2009) 1.47
Lysosomal exocytosis is impaired in mucolipidosis type IV. Mol Genet Metab (2006) 1.45
Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations. Best Pract Res Clin Rheumatol (2008) 1.44
Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab (2004) 1.44
Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes. Bone (2009) 1.35
The empirical foundations of telemedicine interventions for chronic disease management. Telemed J E Health (2014) 1.34
The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am J Physiol Endocrinol Metab (2009) 1.32
pH Sensing by the calcium-sensing receptor. J Biol Chem (2004) 1.32
Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway. FEBS Lett (2002) 1.31
Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response. Biochemistry (2009) 1.27
Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology. Am J Physiol Gastrointest Liver Physiol (2006) 1.26
The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation. Biochem Pharmacol (2007) 1.23
The role of the calcium-sensing receptor in the development and progression of cancer. Endocr Rev (2009) 1.23
Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes. Bone (2010) 1.22
Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis. PLoS One (2012) 1.19
E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. Eur J Cancer (2004) 1.17
The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J Clin Invest (2004) 1.17
Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV. Biochem Biophys Res Commun (2004) 1.16
The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. J Biol Chem (2008) 1.14
Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression. Biochem Biophys Res Commun (2008) 1.14
Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor. J Biol Chem (2007) 1.13
Calcium-sensing receptor in the brain. Cell Calcium (2004) 1.12
Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia. J Clin Endocrinol Metab (2002) 1.11
Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. BMC Cell Biol (2007) 1.10
Extracellular calcium sensing in rat aortic vascular smooth muscle cells. Biochem Biophys Res Commun (2006) 1.10
A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. J Clin Endocrinol Metab (2003) 1.08
Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function. J Biol Chem (2002) 1.08
Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts. Endocrinology (2005) 1.08
Anti-tumor activity of a new series of benzoxazepine derivatives in breast cancer. Bioorg Med Chem Lett (2009) 1.08
Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism. Eur J Endocrinol (2004) 1.07
A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action. J Bone Miner Res (2011) 1.07
Hypercalcemia and diabetes insipidus in a patient previously treated with lithium. Nat Clin Pract Nephrol (2007) 1.06
Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol (2010) 1.05
Synthesis, isomer characterization, and anti-inflammatory properties of nitroarachidonate. Biochemistry (2007) 1.05
Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts. Endocrinology (2004) 1.04
Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II. Endocrinology (2010) 1.03
Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond. J Physiol (2003) 1.02
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genet (2013) 1.02
The calcium-sensing receptor and calcimimetics in blood pressure modulation. Br J Pharmacol (2011) 1.01
Genetic analysis of extensively drug-resistant Mycobacterium tuberculosis strains in Lisbon, Portugal. J Antimicrob Chemother (2009) 1.01
Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing. Mol Genet Metab (2006) 1.00
Genetic polymorphism and pathogenesis of benign prostatic hyperplasia. BJU Int (2008) 1.00
The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1. J Clin Endocrinol Metab (2007) 0.98
L-amino acids regulate parathyroid hormone secretion. J Biol Chem (2004) 0.97
The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. EMBO J (2010) 0.97
Calcium-sensing receptor in cancer: good cop or bad cop? Endocrine (2008) 0.96
Pilot case-control investigation of risk factors for hip fractures in the urban Indian population. BMC Musculoskelet Disord (2010) 0.95
PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation. Am J Physiol Endocrinol Metab (2002) 0.95
Kaempferol has osteogenic effect in ovariectomized adult Sprague-Dawley rats. Mol Cell Endocrinol (2008) 0.95
Signaling through the extracellular calcium-sensing receptor (CaSR). Adv Exp Med Biol (2012) 0.95
Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression. Am J Physiol Endocrinol Metab (2008) 0.95
Evaluation of a rapid and completely automated real-time reverse transcriptase PCR assay for diagnosis of enteroviral meningitis. J Clin Microbiol (2010) 0.95
Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. Am J Physiol Endocrinol Metab (2012) 0.95
E-learning at Porto Faculty of Medicine. A case study for the subject 'Introduction to Medicine'. Stud Health Technol Inform (2007) 0.93
Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. Endocrinology (2004) 0.93
Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphism. Hypertension (2002) 0.93
Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and vertebral fractures in type 2 diabetes mellitus. Eur J Endocrinol (2008) 0.93
Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications. Am J Pathol (2009) 0.93
Identification of novel 2-((1-(benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)benzoic acid analogues as BMP-2 stimulators. J Med Chem (2012) 0.93
Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes. Calcif Tissue Int (2009) 0.93
A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA. J Biomol Screen (2006) 0.93
[Future perspectives in the treatment of psoriasis: news in biological therapies]. Acta Med Port (2012) 0.92
Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: Possible roles of quercetin and kaempferol. Mol Cell Endocrinol (2009) 0.92
The emerging role of pituitary tumor transforming gene in tumorigenesis. Clin Med Res (2006) 0.92