PubRank

A J Thrasher

Author PubWeight™ 77.52‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Nat Genet 2000 3.00
2 Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain. Br J Haematol 1998 2.97
3 Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation. Blood 2001 1.96
4 In vivo gene transfer to the mouse eye using an HIV-based lentiviral vector; efficient long-term transduction of corneal endothelium and retinal pigment epithelium. Gene Ther 2001 1.93
5 Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome. Br J Haematol 1998 1.87
6 Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245. J Biol Chem 1992 1.77
7 Gene transfer into the mouse retina mediated by an adeno-associated viral vector. Hum Mol Genet 1996 1.67
8 Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis. Blood 2000 1.53
9 Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy. Gene Ther 2005 1.48
10 Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells. Mol Ther 2001 1.47
11 Gene replacement therapy in the retinal degeneration slow (rds) mouse: the effect on retinal degeneration following partial transduction of the retina. Hum Mol Genet 2001 1.46
12 Chorioretinal lesions in patients and carriers of chronic granulomatous disease. J Pediatr 1999 1.44
13 Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy. Leukemia 2007 1.43
14 Correction of SCID-X1 using an enhancerless Vav promoter. Hum Gene Ther 2011 1.43
15 Neonatal dendritic cells are intrinsically biased against Th-1 immune responses. Clin Exp Immunol 2002 1.42
16 An immune response after intraocular administration of an adenoviral vector containing a beta galactosidase reporter gene slows retinal degeneration in the rd mouse. Br J Ophthalmol 2001 1.42
17 Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1. Gene Ther 2002 1.36
18 Chronic granulomatous disease. Clin Exp Immunol 2000 1.30
19 Lentiviral vectors targeting WASp expression to hematopoietic cells, efficiently transduce and correct cells from WAS patients. Gene Ther 2006 1.29
20 Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region. Blood 2000 1.25
21 Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration. Gene Ther 2003 1.17
22 Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells. J Immunol 2001 1.17
23 Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector. Hum Gene Ther 1998 1.16
24 Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells. Gene Ther 2008 1.11
25 Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Ther 2006 1.10
26 Progress and prospects: gene therapy clinical trials (part 1). Gene Ther 2007 1.09
27 Validation of a mutated PRE sequence allowing high and sustained transgene expression while abrogating WHV-X protein synthesis: application to the gene therapy of WAS. Gene Ther 2009 1.08
28 Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome. Eur J Immunol 1998 1.06
29 Adeno-associated virus gene transfer to mouse retina. Hum Gene Ther 1998 1.06
30 Stable rAAV-mediated transduction of rod and cone photoreceptors in the canine retina. Gene Ther 2003 1.06
31 Translational mini-review series on immunodeficiency: molecular defects in common variable immunodeficiency. Clin Exp Immunol 2007 1.03
32 Progress and prospects: gene therapy for inherited immunodeficiencies. Gene Ther 2009 1.03
33 Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors. Gene Ther 2009 1.03
34 Normal development of human fetal hematopoiesis between eight and seventeen weeks' gestation. Am J Obstet Gynecol 2000 1.02
35 Lentiviral transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific transgene expression. Gene Ther 2008 1.02
36 WASP and WIP regulate podosomes in migrating leukocytes. J Microsc 2008 1.01
37 Detailed characterization of the human aorta-gonad-mesonephros region reveals morphological polarity resembling a hematopoietic stromal layer. Dev Dyn 1999 0.98
38 Adeno-associated and herpes simplex viruses as vectors for gene transfer to the corneal endothelium. Cornea 2000 0.94
39 The embryonic origins of human haematopoiesis. Br J Haematol 2001 0.92
40 Immune responses limit adenovirally mediated gene expression in the adult mouse eye. Gene Ther 1998 0.92
41 Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection. Gene Ther 2011 0.92
42 Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences. Gene Ther 2005 0.90
43 High-titer recombinant adeno-associated virus production from replicating amplicons and herpes vectors deleted for glycoprotein H. Hum Gene Ther 1999 0.89
44 Kinetics of transgene expression in mouse retina following sub-retinal injection of recombinant adeno-associated virus. Vision Res 2002 0.89
45 Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector. Gene Ther 2007 0.88
46 Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer. Leukemia 2011 0.87
47 Current progress on gene therapy for primary immunodeficiencies. Gene Ther 2013 0.87
48 Dendritic cells: the bare bones of immunity. Curr Biol 2004 0.86
49 Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12. Br J Cancer 2003 0.84
50 A defined window for efficient gene marking of severe combined immunodeficient-repopulating cells using a gibbon ape leukemia virus-pseudotyped retroviral vector. Hum Gene Ther 2000 0.84
51 Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry. Gene Ther 1998 0.84
52 Critical variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency. Gene Ther 2012 0.83
53 High efficiency gene transfer to human hematopoietic SCID-repopulating cells under serum-free conditions. Blood 1998 0.82
54 Low NADPH oxidase activity in Epstein-Barr-virus-immortalized B-lymphocytes is due to a post-transcriptional block in expression of cytochrome b558. Biochem J 1995 0.82
55 Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12. Br J Cancer 2007 0.82
56 T cell transduction and suicide with an enhanced mutant thymidine kinase. Gene Ther 2002 0.82
57 Hypoxia-regulated transgene expression in experimental retinal and choroidal neovascularization. Gene Ther 2003 0.81
58 Gene therapy progress and prospects: gene therapy for severe combined immunodeficiency. Gene Ther 2003 0.81
59 Rituximab for the treatment of autoimmune cytopenias in children with immune deficiency. Br J Haematol 2007 0.81
60 Protein assays for diagnosis of Wiskott-Aldrich syndrome and X-linked thrombocytopenia. Br J Haematol 2001 0.81
61 Lack of T-cell responses following autologous tumour lysate pulsed dendritic cell vaccination, in patients with relapsed osteosarcoma. Clin Transl Oncol 2012 0.80
62 Wiskott-Aldrich syndrome: current research concepts. Br J Haematol 1998 0.78
63 Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally mediated lacZ reporter gene expression in the mouse retina. Gene Ther 1998 0.78
64 Optimization of recombinant adeno-associated virus production using an herpes simplex virus amplicon system. J Virol Methods 2001 0.77
65 Genetic variants associated with neutrophil function in aggressive periodontitis and healthy controls. J Periodontol 2010 0.77
66 T cell suicide gene therapy to aid haematopoietic stem cell transplantation. Curr Gene Ther 2005 0.77
67 Generation of immunostimulatory dendritic cells from the malignant clone in patients with juvenile myelomonocytic leukemia. Leukemia 2003 0.77
68 Improvement of neuronal visual responses in the superior colliculus in Prph2(Rd2/Rd2) mice following gene therapy. Mol Cell Neurosci 2004 0.76
69 Quality of repopulation in nonobese diabetic severe combined immunodeficient mice engrafted with expanded cord blood CD34+ cells. Blood 1999 0.75