PubRank

Pradipsinh K Rathod

Author PubWeight™ 52.21‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Chemical genetics of Plasmodium falciparum. Nature 2010 5.52
2 A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes. Proc Natl Acad Sci U S A 2003 2.48
3 Divergent regulation of dihydrofolate reductase between malaria parasite and human host. Science 2002 2.11
4 Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem 2011 1.94
5 Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem 2009 1.87
6 High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem 2005 1.73
7 Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. J Med Chem 2008 1.67
8 Regulatory hotspots in the malaria parasite genome dictate transcriptional variation. PLoS Biol 2008 1.47
9 Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infect Disord Drug Targets 2010 1.44
10 A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates. PLoS Pathog 2008 1.37
11 Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J Biol Chem 2009 1.32
12 Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. J Biol Chem 2002 1.29
13 Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. J Med Chem 2011 1.28
14 Microfluidic modeling of cell-cell interactions in malaria pathogenesis. PLoS Pathog 2007 1.25
15 Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications. PLoS Pathog 2013 1.25
16 Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection. Mol Biochem Parasitol 2011 1.24
17 Malaria in South Asia: prevalence and control. Acta Trop 2012 1.23
18 Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. J Biol Chem 2005 1.18
19 Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development. Eukaryot Cell 2008 1.15
20 Deformability limits of Plasmodium falciparum-infected red blood cells. Cell Microbiol 2009 1.14
21 Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase. Biochemistry 2008 1.13
22 Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo. PLoS Negl Trop Dis 2008 1.10
23 Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol Biochem Parasitol 2006 0.99
24 Malaria-attributed death rates in India. Lancet 2011 0.97
25 Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem 2014 0.96
26 Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX. PLoS One 2008 0.95
27 Prodrug activation by Cryptosporidium thymidine kinase. J Biol Chem 2010 0.94
28 Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Mol Biochem Parasitol 2006 0.93
29 Malaria evolution in South Asia: knowledge for control and elimination. Acta Trop 2012 0.91
30 Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase. Mol Biochem Parasitol 2009 0.89
31 The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol 2010 0.88
32 Stochastic versus stable transcriptional differences on Plasmodium falciparum DNA microarrays. Int J Parasitol 2002 0.84
33 Microfluidic approaches to malaria pathogenesis. Cell Microbiol 2008 0.84
34 Prized malaria drug target nailed. Nat Struct Biol 2003 0.84
35 Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients. Cell Microbiol 2012 0.83
36 Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase. J Med Chem 2012 0.81
37 Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase. Mol Biochem Parasitol 2005 0.80
38 A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway. J Biol Chem 2013 0.79
39 A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells. Lab Chip 2011 0.79
40 Clonal variants of Plasmodium falciparum exhibit a narrow range of rolling velocities to host receptor CD36 under dynamic flow conditions. Eukaryot Cell 2013 0.78
41 Expression of functional Plasmodium falciparum enzymes using a wheat germ cell-free system. Eukaryot Cell 2013 0.77