Published in Chem Biol on January 01, 2005
The selectivity of protein kinase inhibitors: a further update. Biochem J (2007) 15.73
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol (2008) 3.84
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci U S A (2007) 2.37
Proteomic profiling of metalloprotease activities with cocktails of active-site probes. Nat Chem Biol (2006) 2.25
Activity-based protein profiling for biochemical pathway discovery in cancer. Nat Rev Cancer (2010) 1.84
Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis. Blood (2010) 1.73
Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics. J Hematol Oncol (2013) 1.59
Rapamycin and mTOR kinase inhibitors. J Chem Biol (2008) 1.51
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol (2007) 1.42
Application of activity-based probes to the study of enzymes involved in cancer progression. Curr Opin Genet Dev (2008) 1.17
PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling. Am J Physiol Lung Cell Mol Physiol (2008) 1.12
Slow self-activation enhances the potency of viridin prodrugs. J Med Chem (2008) 0.99
Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J Biol Chem (2008) 0.97
Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs. Mol Cancer Res (2009) 0.94
Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs. Dev Biol (2008) 0.94
Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis. ACS Chem Biol (2012) 0.94
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. J Biol Chem (2010) 0.94
Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage. Mol Biol Cell (2009) 0.91
Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors. J Am Chem Soc (2012) 0.90
Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity. Mol Cells (2011) 0.90
Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors. Angew Chem Int Ed Engl (2012) 0.88
Modulating polo-like kinase 1 as a means for cancer chemoprevention. Pharm Res (2010) 0.87
The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells. J Immunol (2013) 0.86
The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats. Exp Mol Med (2012) 0.86
Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation. PLoS Comput Biol (2010) 0.85
Regulatory roles of the PI3K/Akt signaling pathway in rats with severe acute pancreatitis. PLoS One (2013) 0.85
Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules. J Chem Biol (2008) 0.83
Selective expansion of memory CD4(+) T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells. Eur J Immunol (2008) 0.82
Novel approach for interleukin-23 up-regulation in human dendritic cells and the impact on T helper type 17 generation. Immunology (2011) 0.81
Wortmannin, PI3K/Akt signaling pathway inhibitor, attenuates thyroid injury associated with severe acute pancreatitis in rats. Int J Clin Exp Pathol (2015) 0.80
Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms. Curr Opin Chem Biol (2015) 0.79
IDEA: Integrated Drug Expression Analysis-Integration of Gene Expression and Clinical Data for the Identification of Therapeutic Candidates. CPT Pharmacometrics Syst Pharmacol (2015) 0.78
Engineering small molecule specificity in nearly identical cellular environments. Bioorg Med Chem Lett (2007) 0.77
PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis. Biomed Res Int (2015) 0.77
Computational design of targeted inhibitors of polo-like kinase 1 (plk1). Bioinform Biol Insights (2012) 0.77
Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2. Am J Physiol Heart Circ Physiol (2013) 0.76
Application of activity-based protein profiling to study enzyme function in adipocytes. Methods Enzymol (2014) 0.75
Cuprous oxide nanoparticle-inhibited melanoma progress by targeting melanoma stem cells. Int J Nanomedicine (2017) 0.75
Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. J Med Chem (2016) 0.75
GLCCI1 is a novel component associated with the PI3K signaling pathway in podocyte foot processes. Exp Mol Med (2016) 0.75
High-resolution functional proteomics by active-site peptide profiling. Proc Natl Acad Sci U S A (2005) 1.23
Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. J Biol Chem (2006) 0.98
Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast. Mol Cell Proteomics (2003) 0.95
Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7. Bioorg Med Chem Lett (2005) 0.88
Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. Bioorg Med Chem Lett (2006) 0.86
ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement. Biochemistry (2015) 0.84
Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitors. Bioorg Med Chem Lett (2005) 0.82
Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury. J Pharmacol Toxicol Methods (2009) 0.82
Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase. Mol Cancer Res (2004) 0.81
Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells. Environ Mol Mutagen (2009) 0.80
Design and synthesis of AX7574: a microcystin-derived, fluorescent probe for serine/threonine phosphatases. Bioconjug Chem (2004) 0.78
DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Regul Pept (2013) 0.78
Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors. Bioorg Med Chem Lett (2013) 0.77
Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta. Bioorg Med Chem Lett (2008) 0.76
Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2). Bioorg Med Chem Lett (2011) 0.76
Correction: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics. PLoS One (2017) 0.75
Efficient nuclear transport of structurally disturbed cargo: mutations in a cargo protein switch its cognate karyopherin. PLoS One (2011) 0.75
Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3β (GSK-3β) inhibitors for type 2 diabetics. Bioorg Med Chem (2011) 0.75
Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA₂. Bioorg Med Chem Lett (2012) 0.75
Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1). Bioorg Med Chem Lett (2012) 0.75
6-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3β: discovery of nitrile derivatives with picomolar potency. Bioorg Med Chem Lett (2011) 0.75
Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β. Bioorg Med Chem Lett (2011) 0.75