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1
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Structural basis of integrin regulation and signaling.
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Annu Rev Immunol
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2007
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8.60
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2
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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins.
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Science
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2003
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5.58
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3
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Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif.
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Cell
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2008
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4.00
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4
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Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression.
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Nature
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2003
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3.77
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5
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Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target.
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Science
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2008
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3.51
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6
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RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.
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Dev Cell
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2004
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3.27
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7
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Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1.
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Proc Natl Acad Sci U S A
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2007
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2.27
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8
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The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.
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J Cell Biol
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2004
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2.22
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9
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The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.
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Nat Immunol
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2012
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2.17
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10
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Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.
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Proc Natl Acad Sci U S A
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2005
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1.73
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11
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Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.
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J Biol Chem
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2002
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1.61
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12
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Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces.
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Am J Physiol Cell Physiol
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2010
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1.53
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13
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Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.
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Blood
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2007
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1.52
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14
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Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.
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Proc Natl Acad Sci U S A
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2006
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1.32
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15
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Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2.
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Proc Natl Acad Sci U S A
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2005
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1.24
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16
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Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.
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J Clin Invest
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2007
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1.23
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17
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Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes.
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Blood
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2009
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1.15
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18
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Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1.
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J Biol Chem
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2002
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1.14
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19
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Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-α-activated endothelial cells via both leukocyte-like and novel mechanisms.
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Stem Cells
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2012
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1.14
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20
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New observations on the trafficking and diapedesis of monocytes.
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Curr Opin Hematol
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2010
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1.13
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21
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ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene.
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J Biol Chem
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2012
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1.11
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22
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Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2.
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Proc Natl Acad Sci U S A
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2006
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1.10
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23
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Cellular and extracellular programming of cell fate through engineered intracrine-, paracrine-, and endocrine-like mechanisms.
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Biomaterials
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2011
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1.08
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24
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Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults.
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Crit Care
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2014
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1.05
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25
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A small molecule agonist of an integrin, alphaLbeta2.
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J Biol Chem
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2006
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1.04
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26
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Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells.
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J Immunol
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2012
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1.04
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27
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Settings and mechanisms for trans-cellular diapedesis.
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Front Biosci (Landmark Ed)
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2009
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1.03
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28
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Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.
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J Cell Biol
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2013
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1.03
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29
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Differential interaction of GRK2 with members of the G alpha q family.
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Biochemistry
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2003
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0.99
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30
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Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots.
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Proc Natl Acad Sci U S A
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2007
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0.99
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31
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Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization.
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Proc Natl Acad Sci U S A
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2007
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0.96
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32
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Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha(4) integrins.
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Blood
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2008
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0.91
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33
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Intravital imaging of mesenchymal stem cell trafficking and association with platelets and neutrophils.
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Stem Cells
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2015
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0.87
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34
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Novel role of CD47 in rat microvascular endothelium: signaling and regulation of T-cell transendothelial migration.
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Arterioscler Thromb Vasc Biol
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2013
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0.81
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35
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Active Rap1, a small GTPase that induces malignant transformation of hematopoietic progenitors, localizes in the nucleus and regulates protein expression.
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Leuk Lymphoma
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2007
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0.81
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36
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Central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium.
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Proc Natl Acad Sci U S A
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2014
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0.78
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37
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Glassy dynamics, cell mechanics, and endothelial permeability.
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J Phys Chem B
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2013
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0.77
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