Published in J Cell Physiol on July 01, 2005
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A (2006) 7.48
Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophys J (2007) 4.59
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J (2006) 4.06
Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06
Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. J Cell Sci (2008) 3.86
Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization. Biophys J (2008) 3.49
The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells. Cancer Res (2009) 3.42
Integrin-dependent actomyosin contraction regulates epithelial cell scattering. J Cell Biol (2005) 3.20
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol (2010) 2.96
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration. Sci Transl Med (2011) 2.35
Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength. Biophys J (2009) 2.34
Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol (2012) 2.33
Cell-cell mechanical communication through compliant substrates. Biophys J (2008) 2.31
Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev (2007) 1.94
Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol (2014) 1.94
The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β. Biomaterials (2011) 1.93
Independent regulation of tumor cell migration by matrix stiffness and confinement. Proc Natl Acad Sci U S A (2012) 1.89
Stiffness gradients mimicking in vivo tissue variation regulate mesenchymal stem cell fate. PLoS One (2011) 1.86
A hitchhiker's guide to mechanobiology. Dev Cell (2011) 1.72
Microarchitecture of three-dimensional scaffolds influences cell migration behavior via junction interactions. Biophys J (2008) 1.61
Neutrophil morphology and migration are affected by substrate elasticity. Blood (2009) 1.53
Materials as stem cell regulators. Nat Mater (2014) 1.53
The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system. Biomaterials (2008) 1.51
ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK. J Bone Miner Res (2009) 1.43
Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation. Biophys J (2010) 1.43
Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet. Sci Signal (2008) 1.42
Matrix strains induced by cells: Computing how far cells can feel. Cell Mol Bioeng (2009) 1.41
The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration. Sci Rep (2012) 1.36
Dimensions in cell migration. Curr Opin Cell Biol (2013) 1.36
Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology. PLoS One (2009) 1.34
Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy. Biophys J (2010) 1.31
Fibronectin in aging extracellular matrix fibrils is progressively unfolded by cells and elicits an enhanced rigidity response. Faraday Discuss (2008) 1.30
Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform. Biomaterials (2011) 1.27
Defining the role of matrix compliance and proteolysis in three-dimensional cell spreading and remodeling. Biophys J (2008) 1.25
Strategies and applications for incorporating physical and chemical signal gradients in tissue engineering. Tissue Eng Part B Rev (2008) 1.24
Perspectives on whole-organ assembly: moving toward transplantation on demand. J Clin Invest (2012) 1.22
Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res (2014) 1.21
Neutrophil adhesion and chemotaxis depend on substrate mechanics. J Phys Condens Matter (2010) 1.21
3D collagen alignment limits protrusions to enhance breast cancer cell persistence. Biophys J (2014) 1.19
Determinants of maximal force transmission in a motor-clutch model of cell traction in a compliant microenvironment. Biophys J (2013) 1.17
Nanotopography as modulator of human mesenchymal stem cell function. Biomaterials (2012) 1.16
Blast-induced phenotypic switching in cerebral vasospasm. Proc Natl Acad Sci U S A (2011) 1.14
The biomechanical integrin. J Biomech (2009) 1.09
Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling. Curr Opin Cell Biol (2008) 1.08
The influence of stereolithographic scaffold architecture and composition on osteogenic signal expression with rat bone marrow stromal cells. Biomaterials (2011) 1.07
Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness. Biotechnol Bioeng (2011) 1.05
Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition. Mol Biol Cell (2012) 1.04
Mechanosensing of substrate thickness. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 1.04
Multi-scale mechanics from molecules to morphogenesis. Int J Biochem Cell Biol (2009) 1.03
Modulation of Nuclear Shape by Substrate Rigidity. Cell Mol Bioeng (2013) 1.03
Automated single-cell motility analysis on a chip using lensfree microscopy. Sci Rep (2014) 1.03
Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis. J Cell Physiol (2010) 1.02
MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin. J Cell Sci (2011) 1.02
Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro. PLoS Comput Biol (2014) 1.02
The influence of collagen-glycosaminoglycan scaffold relative density and microstructural anisotropy on tenocyte bioactivity and transcriptomic stability. J Mech Behav Biomed Mater (2011) 1.00
Physical biology in cancer. 4. Physical cues guide tumor cell adhesion and migration. Am J Physiol Cell Physiol (2013) 0.99
Measurements of elastic moduli of silicone gel substrates with a microfluidic device. PLoS One (2011) 0.99
Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression. Mol Cancer (2010) 0.99
Nonlinear elastic properties of polyacrylamide gels: implications for quantification of cellular forces. Biorheology (2009) 0.99
Modulating the gelation properties of self-assembling peptide amphiphiles. ACS Nano (2009) 0.98
Determinants of cell-material crosstalk at the interface: towards engineering of cell instructive materials. J R Soc Interface (2012) 0.98
Three-dimensional hMSC motility within peptide-functionalized PEG-based hydrogels of varying adhesivity and crosslinking density. Acta Biomater (2013) 0.98
Minimization of thermodynamic costs in cancer cell invasion. Proc Natl Acad Sci U S A (2013) 0.98
Biomechanical regulation of vascular smooth muscle cell functions: from in vitro to in vivo understanding. J R Soc Interface (2013) 0.97
Controlling matrix stiffness and topography for the study of tumor cell migration. Cell Adh Migr (2012) 0.95
Cell-cell interactions mediate the response of vascular smooth muscle cells to substrate stiffness. Biophys J (2011) 0.95
Age-related vascular stiffening: causes and consequences. Front Genet (2015) 0.93
Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation. Proc Natl Acad Sci U S A (2014) 0.93
Soft materials to treat central nervous system injuries: evaluation of the suitability of non-mammalian fibrin gels. Biochim Biophys Acta (2009) 0.92
Biophysical mechanisms of single-cell interactions with microtopographical cues. Biomed Microdevices (2010) 0.92
Intercellular mechanotransduction during multicellular morphodynamics. J R Soc Interface (2010) 0.92
Biomaterial-mediated delivery of degradative enzymes to improve meniscus integration and repair. Acta Biomater (2013) 0.90
Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes. J Biol Chem (2010) 0.90
A model of fibroblast motility on substrates with different rigidities. Biophys J (2010) 0.89
Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility. Mol Biol Cell (2013) 0.89
Biochemical and mechanical extracellular matrix properties dictate mammary epithelial cell motility and assembly. Biotechnol J (2011) 0.89
Effects of supported lipid monolayer fluidity on the adhesion of hematopoietic progenitor cell lines to fibronectin-derived peptide ligands for alpha5beta1 and alpha4beta1 integrins. Langmuir (2009) 0.88
Contractile equilibration of single cells to step changes in extracellular stiffness. Biophys J (2012) 0.87
Biocompatible tissue scaffold compliance promotes salivary gland morphogenesis and differentiation. Tissue Eng Part A (2014) 0.87
Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK. Cell Mol Bioeng (2013) 0.87
Regulation of tissue fibrosis by the biomechanical environment. Biomed Res Int (2013) 0.86
Probabilistic Voxel-Fe model for single cell motility in 3D. In Silico Cell Tissue Sci (2014) 0.86
The effect of substrate modulus on the growth and function of matrix-embedded endothelial cells. Biomaterials (2012) 0.85
From molecular signal activation to locomotion: an integrated, multiscale analysis of cell motility on defined matrices. PLoS One (2011) 0.85
Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks. Acta Biomater (2014) 0.85
Substrate Stiffness Affects Human Keratinocyte Colony Formation. Cell Mol Bioeng (2015) 0.84
Introduction to cell-hydrogel mechanosensing. Interface Focus (2014) 0.84
Synergistic effects of matrix nanotopography and stiffness on vascular smooth muscle cell function. Tissue Eng Part A (2014) 0.84
Substrate stiffness regulates solubility of cellular vimentin. Mol Biol Cell (2013) 0.84
Scaffold stiffness influences cell behavior: opportunities for skeletal tissue engineering. Open Orthop J (2008) 0.83
Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors. Proc Natl Acad Sci U S A (2015) 0.83
Effect of shear stress and substrate on endothelial DAPK expression, caspase activity, and apoptosis. BMC Res Notes (2013) 0.83
Angiogenic responses are enhanced in mechanically and microscopically characterized, microbial transglutaminase crosslinked collagen matrices with increased stiffness. Acta Biomater (2013) 0.83
Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging. J Phys Condens Matter (2010) 0.83
Hypertrophy, gene expression, and beating of neonatal cardiac myocytes are affected by microdomain heterogeneity in 3D. Biomed Microdevices (2010) 0.82
Dissecting Collective Cell Behavior in Polarization and Alignment on Micropatterned Substrates. Biophys J (2015) 0.82
Mapping three-dimensional stress and strain fields within a soft hydrogel using a fluorescence microscope. Biophys J (2012) 0.82
Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior. Biophys J (2015) 0.81
Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension. JCI Insight (2016) 0.81
Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy. Biophys J (2006) 2.71
The effect of matrix density on the regulation of 3-D capillary morphogenesis. Biophys J (2007) 2.37
The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells. Biomaterials (2006) 2.23
Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue Eng Part A (2009) 2.14
Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation. Tissue Eng (2006) 1.98
MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis. Dev Cell (2013) 1.95
Engineering microscale cellular niches for three-dimensional multicellular co-cultures. Lab Chip (2009) 1.77
The emergence of ECM mechanics and cytoskeletal tension as important regulators of cell function. Cell Biochem Biophys (2007) 1.62
Intrinsic mechanical properties of the extracellular matrix affect the behavior of pre-osteoblastic MC3T3-E1 cells. Am J Physiol Cell Physiol (2006) 1.60
The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system. Biomaterials (2008) 1.51
Matrix composition regulates three-dimensional network formation by endothelial cells and mesenchymal stem cells in collagen/fibrin materials. Angiogenesis (2012) 1.47
Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp Cell Res (2010) 1.43
ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK. J Bone Miner Res (2009) 1.43
Endothelial cell traction and ECM density influence both capillary morphogenesis and maintenance in 3-D. Am J Physiol Cell Physiol (2009) 1.42
Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis. Oncogene (2004) 1.37
Matrix metalloproteinase control of capillary morphogenesis. Crit Rev Eukaryot Gene Expr (2008) 1.32
Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(L-lactic-co-glycolic acid) scaffold. Biomaterials (2007) 1.31
Adhesion of mesenchymal stem cells to polymer scaffolds occurs via distinct ECM ligands and controls their osteogenic differentiation. J Biomed Mater Res A (2006) 1.27
Vitronectin and collagen I differentially regulate osteogenesis in mesenchymal stem cells. Biochem Biophys Res Commun (2006) 1.24
The regulation of osteogenesis by ECM rigidity in MC3T3-E1 cells requires MAPK activation. J Cell Physiol (2007) 1.20
Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms. Angiogenesis (2010) 1.14
Concentration independent modulation of local micromechanics in a fibrin gel. PLoS One (2011) 1.11
The effect of cyclic strain on embryonic stem cell-derived cardiomyocytes. Biomaterials (2007) 1.05
Stromal cell identity influences the in vivo functionality of engineered capillary networks formed by co-delivery of endothelial cells and stromal cells. Tissue Eng Part A (2013) 1.05
Effects of extracellular matrix density and mesenchymal stem cells on neovascularization in vivo. Tissue Eng Part A (2010) 1.04
Extracellular matrix remodeling, integrin expression, and downstream signaling pathways influence the osteogenic differentiation of mesenchymal stem cells on poly(lactide-co-glycolide) substrates. Tissue Eng Part A (2009) 1.00
Assessing the permeability of engineered capillary networks in a 3D culture. PLoS One (2011) 0.98
Bone marrow stromal cells stimulate an angiogenic program that requires endothelial MT1-MMP. J Cell Physiol (2012) 0.96
Effects of tissue stiffness, ultrasound frequency, and pressure on histotripsy-induced cavitation bubble behavior. Phys Med Biol (2015) 0.95
Recreating the perivascular niche ex vivo using a microfluidic approach. Biotechnol Bioeng (2010) 0.94
A novel three-dimensional model to quantify metastatic melanoma invasion. Mol Cancer Ther (2007) 0.93
Capillary morphogenesis in PEG-collagen hydrogels. Biomaterials (2013) 0.87
The influence of ascorbic acid, TGF-beta1, and cell-mediated remodeling on the bulk mechanical properties of 3-D PEG-fibrinogen constructs. Biomaterials (2009) 0.86
Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their α6β1 integrin receptor. Exp Cell Res (2013) 0.84
Aqueous two-phase printing of cell-containing contractile collagen microgels. Biomaterials (2013) 0.84
Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D. Integr Biol (Camb) (2012) 0.81
Extracellular matrix elasticity and topography: material-based cues that affect cell function via conserved mechanisms. J Biomed Mater Res A (2014) 0.80
Dual-phase osteogenic and vasculogenic engineered tissue for bone formation. Tissue Eng Part A (2014) 0.79
Matrix identity and tractional forces influence indirect cardiac reprogramming. Sci Rep (2013) 0.79
Characterization of the crosslinking kinetics of multi-arm poly(ethylene glycol) hydrogels formed via Michael-type addition. Soft Matter (2016) 0.78
Protease-sensitive PEG hydrogels regulate vascularization in vitro and in vivo. Macromol Biosci (2014) 0.78
A safe and efficient method to retrieve mesenchymal stem cells from three-dimensional fibrin gels. Tissue Eng Part C Methods (2013) 0.78
A novel time-varying poly lactic-co glycolic acid external sheath for vein grafts designed under physiological loading. Tissue Eng (2007) 0.78
Stem cells derived from tooth periodontal ligament enhance functional angiogenesis by endothelial cells. Tissue Eng Part A (2013) 0.77
Mechanical strain controls endothelial patterning during angiogenic sprouting. Cell Mol Bioeng (2012) 0.76
Increased thermal pain sensitivity in animals exposed to chronic high dose Vicodin but not pure hydrocodone. Pain Physician (2014) 0.75