PubRank

Chuanyue Wu

Author PubWeight™ 98.52‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell 2003 3.19
2 Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol 2008 2.88
3 Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 2003 2.77
4 The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility. J Biol Chem 2007 2.20
5 Kindlins: essential regulators of integrin signalling and cell-matrix adhesion. EMBO Rep 2008 2.10
6 Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. J Am Soc Nephrol 2006 1.90
7 PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. J Biol Chem 2003 1.82
8 Migfilin, a molecular switch in regulation of integrin activation. J Biol Chem 2008 1.68
9 The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell 2009 1.62
10 Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J Cell Sci 2002 1.58
11 Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology 2009 1.54
12 ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene 2005 1.46
13 Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. J Biol Chem 2002 1.42
14 Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Mol Biol Cell 2003 1.38
15 Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility. Mol Cell 2005 1.37
16 Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria. Kidney Int 2010 1.36
17 Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. J Clin Invest 2007 1.33
18 Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology 2008 1.31
19 Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex. FASEB J 2002 1.28
20 A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migration. J Biol Chem 2001 1.28
21 Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration. J Biol Chem 2006 1.27
22 Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci 2011 1.27
23 PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells. J Biol Chem 2007 1.26
24 Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression. Cancer Res 2009 1.25
25 Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer. Mol Cancer Res 2006 1.24
26 Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma. J Natl Cancer Inst 2007 1.22
27 Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Lab Invest 2005 1.18
28 PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase. J Am Soc Nephrol 2007 1.17
29 CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt. J Cell Biol 2003 1.16
30 Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. J Biol Chem 2004 1.14
31 Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation. J Biol Chem 2011 1.12
32 Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development 2009 1.11
33 Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival. J Biol Chem 2005 1.11
34 Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation. J Biol Chem 2010 1.10
35 ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling. Curr Opin Cell Biol 2012 1.10
36 Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis. Hepatology 2007 1.10
37 Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation 2009 1.08
38 Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. Nat Struct Biol 2003 1.08
39 Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem 2012 1.07
40 Physical and functional association of migfilin with cell-cell adhesions. J Cell Sci 2005 1.06
41 Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival. J Am Soc Nephrol 2005 1.06
42 Phosphorylation of alpha-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin. J Biol Chem 2009 1.03
43 Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development. Mol Cell Neurosci 2006 1.02
44 Histone deacetylase (HDAC) 10 suppresses cervical cancer metastasis through inhibition of matrix metalloproteinase (MMP) 2 and 9 expression. J Biol Chem 2013 1.02
45 EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness. Int J Cancer 2002 1.00
46 Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress. Proc Natl Acad Sci U S A 2007 1.00
47 Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-γ and STAT3 protein signaling pathways. J Biol Chem 2012 1.00
48 The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. J Biol Chem 2008 1.00
49 Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. J Biol Chem 2008 0.99
50 Integrin-linked kinase regulates N-WASp-mediated actin polymerization and tension development in tracheal smooth muscle. J Biol Chem 2007 0.99
51 NO-dependent osteoclast motility: reliance on cGMP-dependent protein kinase I and VASP. J Cell Sci 2005 0.96
52 A suppressive role of mitogen inducible gene-2 in mesenchymal cancer cell invasion. Mol Cancer Res 2008 0.96
53 Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling. J Biol Chem 2009 0.95
54 Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma. J Exp Clin Cancer Res 2014 0.94
55 Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation. Biochem Biophys Res Commun 2006 0.94
56 Migfilin regulates esophageal cancer cell motility through promoting GSK-3β-mediated degradation of β-catenin. Mol Cancer Res 2012 0.93
57 Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression. Cancer Res 2010 0.93
58 The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. Dev Biol 2003 0.93
59 Assembly and signaling of adhesion complexes. Curr Top Dev Biol 2005 0.92
60 Kindler syndrome and periodontal disease: review of the literature and a 12-year follow-up case. J Periodontol 2008 0.91
61 Tissue plasminogen activator activates NF-κB through a pathway involving annexin A2/CD11b and integrin-linked kinase. J Am Soc Nephrol 2012 0.91
62 Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle. J Cell Biol 2009 0.90
63 TGF-beta1 regulates the PINCH-1-integrin-linked kinase-alpha-parvin complex in glomerular cells. J Am Soc Nephrol 2006 0.89
64 PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression. PLoS One 2011 0.89
65 Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significance. Eur J Cancer 2008 0.89
66 Cell-adhesion assays. Methods Mol Biol 2005 0.88
67 Tenascin-X is a novel diagnostic marker of malignant mesothelioma. Am J Surg Pathol 2009 0.87
68 Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene. Hepatology 2011 0.87
69 Localization and potential function of kindlin-1 in periodontal tissues. Eur J Oral Sci 2009 0.86
70 Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes. Arthritis Res Ther 2010 0.86
71 Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. PLoS One 2013 0.86
72 Integrin-linked kinase induces both senescence-associated alterations and extracellular fibronectin assembly in aging cardiac fibroblasts. J Gerontol A Biol Sci Med Sci 2006 0.83
73 Expression and significance of integrin-linked kinase in cultured cells, normal tissue, and diseased tissue of aging rat kidneys. J Gerontol A Biol Sci Med Sci 2004 0.83
74 Roles of PINCH-2 in regulation of glomerular cell shape change and fibronectin matrix deposition. Am J Physiol Renal Physiol 2008 0.82
75 Alpha-actinin-4 and CLP36 protein deficiencies contribute to podocyte defects in multiple human glomerulopathies. J Biol Chem 2011 0.81
76 Nck-2 interacts with focal adhesion kinase and modulates cell motility. Int J Biochem Cell Biol 2002 0.81
77 TGF-beta1-induced PINCH-1-ILK-alpha-parvin complex formation regulates mesangial cell proliferation and hypertrophy. Exp Mol Med 2007 0.81
78 Beta1-integrin signaling is essential for lens fiber survival. Gene Regul Syst Bio 2007 0.81
79 Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice. Comp Hepatol 2011 0.80
80 αV-integrins are required for mechanotransduction in MDCK epithelial cells. PLoS One 2013 0.79
81 The PDZ-ligand and Src-homology type 3 domains of epidemic avian influenza virus NS1 protein modulate human Src kinase activity during viral infection. PLoS One 2011 0.79
82 Spatiotemporal response of living cell structures in Dictyostelium discoideum with semiconductor quantum dots. Nano Lett 2008 0.78
83 A reproducible technique for specific labeling of antigens using preformed fluorescent molecular IgG-F(ab')2 complexes from primary antibodies of the same species. Microsc Res Tech 2010 0.77
84 Migfilin's elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via β-catenin upregulation. Biochem Biophys Res Commun 2012 0.77
85 Mitogen-inducible Gene-2 (MIG2) and migfilin expression is reduced in samples of human breast cancer. Anticancer Res 2013 0.76
86 Migfilin, α-parvin and β-parvin are differentially expressed in ovarian serous carcinoma effusions, primary tumors and solid metastases. Gynecol Oncol 2012 0.75