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1
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A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).
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ACS Chem Biol
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2006
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2.57
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2
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Reversible Ser/Thr SHIP phosphorylation: a new paradigm in phosphoinositide signalling?: Targeting of SHIP1/2 phosphatases may be controlled by phosphorylation on Ser and Thr residues.
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Bioessays
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2012
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1.40
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3
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Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils.
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Immunity
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2007
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1.33
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4
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Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression.
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Cancer Res
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2006
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1.24
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5
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Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development.
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Nat Immunol
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2003
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1.16
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6
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Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.
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Proc Natl Acad Sci U S A
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2007
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1.12
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7
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The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
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Adv Enzyme Regul
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2003
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1.12
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8
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Phosphoinositide phosphatases in a network of signalling reactions.
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Pflugers Arch
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2007
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1.03
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9
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Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.
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Cell Signal
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2012
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1.00
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10
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Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B.
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Biochem Biophys Res Commun
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2002
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0.97
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11
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The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity.
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Cell Signal
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2006
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0.97
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12
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Phosphatidylinositol 3,4,5-trisphosphate: an early mediator of insulin-stimulated sodium transport in A6 cells.
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Am J Physiol Renal Physiol
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2004
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0.93
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13
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Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes.
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FASEB J
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2007
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0.93
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14
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The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.
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Biochem J
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2003
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0.92
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15
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The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.
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Cell Signal
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2007
|
0.92
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16
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Synthesis and biological activity of PTEN-resistant analogues of phosphatidylinositol 3,4,5-trisphosphate.
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J Am Chem Soc
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2006
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0.91
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17
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Protein phosphatase 2A PR130/B''alpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling.
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FASEB J
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2009
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0.90
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|
18
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Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.
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Proc Natl Acad Sci U S A
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2008
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0.89
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19
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SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels.
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Biochem J
|
2003
|
0.89
|
|
20
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The role of calmodulin for inositol 1,4,5-trisphosphate receptor function.
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Biochim Biophys Acta
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2002
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0.88
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21
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A diverse family of inositol 5-phosphatases playing a role in growth and development in Dictyostelium discoideum.
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J Biol Chem
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2002
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0.87
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22
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SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line.
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Biochem Biophys Res Commun
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2002
|
0.86
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|
23
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Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha.
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Chembiochem
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2008
|
0.86
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24
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SHIP2 interaction with the cytoskeletal protein Vinexin.
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FEBS J
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2005
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0.86
|
|
25
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Hydrogen peroxide and epidermal growth factor activate phosphatidylinositol 3-kinase and increase sodium transport in A6 cell monolayers.
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Am J Physiol Renal Physiol
|
2005
|
0.85
|
|
26
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Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues.
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Chembiochem
|
2005
|
0.85
|
|
27
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The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts.
|
Cell Signal
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2007
|
0.84
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28
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The host phosphoinositide 5-phosphatase SHIP2 regulates dissemination of vaccinia virus.
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J Virol
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2011
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0.84
|
|
29
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Inhibition of insulin-stimulated hydrogen peroxide production prevents stimulation of sodium transport in A6 cell monolayers.
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Am J Physiol Renal Physiol
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2009
|
0.83
|
|
30
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3-hydroxybenzene 1,2,4-trisphosphate, a novel second messenger mimic and unusual substrate for type-I myo-inositol 1,4,5-trisphosphate 5-phosphatase: Synthesis and physicochemistry.
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Chembiochem
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2006
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0.82
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31
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SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor.
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J Biol Chem
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2009
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0.82
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32
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Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3-mediated Ca2+ signaling.
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J Cell Physiol
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2005
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0.82
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33
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A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery.
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ACS Chem Biol
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2012
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0.81
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34
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ENDOGLIN/CD105 is expressed in KIT positive cells in the gut and in gastrointestinal stromal tumours.
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J Cell Mol Med
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2012
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0.81
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35
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Hyperosmotic stress stimulates inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate formation independently of bis-diphosphoinositol tetrakisphosphate modulation.
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Biochem Biophys Res Commun
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2005
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0.81
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36
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The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity.
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Cell Signal
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2008
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0.81
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37
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The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners.
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J Cell Physiol
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2008
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0.81
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38
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SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein.
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Mol Biol Cell
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2013
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0.81
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39
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Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.
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Biochem J
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2013
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0.81
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40
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Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability.
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Biochem J
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2011
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0.80
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41
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Ca2+ uptake and release properties of a thapsigargin-insensitive nonmitochondrial Ca2+ store in A7r5 and 16HBE14o- cells.
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J Biol Chem
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2001
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0.80
|
|
42
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5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration.
|
Chembiochem
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2010
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0.80
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|
43
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Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts.
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FEBS J
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2005
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0.80
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|
44
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SHIP2 controls PtdIns(3,4,5)P(3) levels and PKB activity in response to oxidative stress.
|
Cell Signal
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2007
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0.80
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45
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Neurotensin receptor 1 is expressed in gastrointestinal stromal tumors but not in interstitial cells of Cajal.
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PLoS One
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2011
|
0.79
|
|
46
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The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.
|
Biochem Biophys Res Commun
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2003
|
0.79
|
|
47
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Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.
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Brain
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2014
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0.79
|
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48
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Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate.
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Bioorg Med Chem Lett
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2007
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0.79
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49
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Actin-based confinement of calcium responses during Shigella invasion.
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Nat Commun
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2013
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0.79
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50
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Thyrotropin stimulates the generation of inositol 1,4,5-trisphosphate in human thyroid cells.
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J Clin Endocrinol Metab
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2005
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0.79
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51
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Abnormal elevated PTEN expression in the mouse antrum of a model of GIST Kit(K641E/K641E).
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Cell Signal
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2011
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0.78
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52
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A specific increase in inositol 1,4,5-trisphosphate 3-kinase B expression upon differentiation of human embryonic stem cells.
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Cell Signal
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2012
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0.78
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53
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How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity?
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Bioessays
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2013
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0.78
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54
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SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts.
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Adv Biol Regul
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2012
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0.78
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55
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Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours.
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J Cell Mol Med
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2009
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0.78
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56
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The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system.
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Pflugers Arch
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2011
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0.78
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57
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Reactive blue 2 inhibition of cyclic AMP-dependent differentiation of rat C6 glioma cells by purinergic receptor-independent inactivation of phosphatidylinositol 3-kinase.
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Biochem Pharmacol
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2004
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0.77
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58
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Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells.
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Adv Biol Regul
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2012
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0.77
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59
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Identification and subcellular distribution of endogenous Ins(1,4,5)P(3) 3-kinase B in mouse tissues.
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Biochem Biophys Res Commun
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2004
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0.77
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60
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SHIP1/2 interaction with tyrosine phosphorylated peptides mimicking an immunoreceptor signalling motif.
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Adv Enzyme Regul
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2006
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0.77
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61
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Insulin increase in MAP kinase phosphorylation is shifted to early time-points by overexpressing APS, while Akt phosphorylation is not influenced.
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Exp Cell Res
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2009
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0.75
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62
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Regulation of SHIP2 function through plasma membrane interaction.
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Adv Enzyme Regul
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2009
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0.75
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63
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Expression and purification in high yield of a functionally active recombinant human Type I inositol(1,4,5)P3 5-phosphatase.
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Protein Expr Purif
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2007
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0.75
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64
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Synthesis of D- and L-myo-inositol 1,2,4,6-tetrakisphosphate, regioisomers of myo-inositol 1,3,4,5 tetrakisphosphate: activity against Ins(1,4,5)P3 binding proteins.
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Org Biomol Chem
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2003
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0.75
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