|
1
|
Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.
|
Clin Cancer Res
|
2005
|
4.84
|
|
2
|
Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta.
|
Blood
|
2006
|
1.51
|
|
3
|
A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.
|
J Pharmacol Exp Ther
|
2006
|
1.36
|
|
4
|
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
|
Arthritis Rheum
|
2007
|
1.06
|
|
5
|
IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.
|
Arthritis Rheum
|
2006
|
0.96
|
|
6
|
SD0006: a potent, selective and orally available inhibitor of p38 kinase.
|
Pharmacology
|
2009
|
0.84
|
|
7
|
Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase.
|
Bioorg Med Chem Lett
|
2011
|
0.77
|
|
8
|
Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase.
|
Bioorg Med Chem Lett
|
2009
|
0.77
|