Published in Respir Med on January 01, 2005
Withdrawal of Inhaled Corticosteroids in Patients With COPD in Primary Care | NCT00440687
Qvar Versus Clenil, a General Practice Research Database Study | NCT01400217
Real-world Effectiveness of Combination Therapy in Asthma | NCT01141465
Device Mixing in Asthma, a General Practice Research Database Study (EBsalbutamol) | NCT01313585
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ (2013) 9.01
A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J (2015) 1.82
External validity of randomised controlled trials in asthma: to whom do the results of the trials apply? Thorax (2006) 1.72
The prevalence of clinically-relevant comorbid conditions in patients with physician-diagnosed COPD: a cross-sectional study using data from NHANES 1999-2008. BMC Pulm Med (2012) 1.61
Asthma control and management in 8,000 European patients: the REcognise Asthma and LInk to Symptoms and Experience (REALISE) survey. NPJ Prim Care Respir Med (2014) 1.54
Impact of a bronchiolitis clinical care pathway on treatment and hospital stay. Eur J Pediatr (2011) 1.43
Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands. BMC Pulm Med (2016) 1.39
Reassessing the evidence hierarchy in asthma: evaluating comparative effectiveness. Curr Allergy Asthma Rep (2011) 1.28
Primary care COPD patients compared with large pharmaceutically-sponsored COPD studies: an UNLOCK validation study. PLoS One (2014) 1.23
Obtaining real-world evidence: the Salford Lung Study. Thorax (2014) 1.09
The health economic impact of disease management programs for COPD: a systematic literature review and meta-analysis. BMC Pulm Med (2013) 1.05
Sub-lingual immunotherapy: world allergy organization position paper 2009. World Allergy Organ J (2009) 1.03
Real-world research and its importance in respiratory medicine. Breathe (Sheff) (2015) 1.01
Breaking new ground: challenging existing asthma guidelines. BMC Pulm Med (2006) 0.98
Withdrawal of inhaled corticosteroids in people with COPD in primary care: a randomised controlled trial. Respir Res (2007) 0.98
Geographic differences in clinical characteristics and management of COPD: the EPOCA study. Int J Chron Obstruct Pulmon Dis (2008) 0.98
Stratified approaches to the treatment of asthma. Br J Clin Pharmacol (2013) 0.98
Health care utilization history, GOLD guidelines, and respiratory medication prescriptions in patients with COPD. Int J Chron Obstruct Pulmon Dis (2010) 0.92
Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity. PLoS One (2012) 0.90
Safety and efficacy of tiotropium Respimat versus HandiHaler in patients naive to treatment with inhaled anticholinergics: a post hoc analysis of the TIOSPIR trial. NPJ Prim Care Respir Med (2015) 0.88
The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in asthma. BMC Pulm Med (2015) 0.88
RECODE: design and baseline results of a cluster randomized trial on cost-effectiveness of integrated COPD management in primary care. BMC Pulm Med (2013) 0.87
Asthma phenotypes: the intriguing selective intervention with Montelukast. Asthma Res Pract (2016) 0.87
The influence of heart disease on characteristics, quality of life, use of health resources, and costs of COPD in primary care settings. BMC Cardiovasc Disord (2010) 0.87
1-year prospective real life monitoring of asthma control and quality of life in Italy. Respir Res (2012) 0.86
Effectiveness of inhaler types for real-world asthma management: retrospective observational study using the GPRD. J Asthma Allergy (2011) 0.82
Eligibility of real-life patients with COPD for inclusion in trials of inhaled long-acting bronchodilator therapy. Respir Res (2016) 0.82
Long-acting beta-agonists plus inhaled corticosteroids safety: a systematic review and meta-analysis of non-randomized studies. Respir Res (2014) 0.82
When should acute exacerbations of COPD be treated with systemic corticosteroids and antibiotics in primary care: a systematic review of current COPD guidelines. NPJ Prim Care Respir Med (2015) 0.82
A real-world evaluation of indacaterol and other bronchodilators in COPD: the INFLOW study. Int J Chron Obstruct Pulmon Dis (2015) 0.81
Clinical significance in COPD patients followed in a real practice. Multidiscip Respir Med (2013) 0.80
Predictors of cost-effectiveness of selected COPD treatments in primary care: UNLOCK study protocol. NPJ Prim Care Respir Med (2015) 0.79
Cost-effectiveness analysis of corticosteroid inhaler devices in primary care asthma management: A real world observational study. Clinicoecon Outcomes Res (2010) 0.79
Simulation-based Evaluation of the Generalizability Index for Study Traits. AMIA Annu Symp Proc (2015) 0.79
Extrafine beclometasone diproprionate/formoterol fumarate: a review of its effects in chronic obstructive pulmonary disease. NPJ Prim Care Respir Med (2016) 0.79
Real-life use of budesonide/formoterol in clinical practice: a 12-month follow-up assessment in a multi-national study of asthma patients established on single-inhaler maintenance and reliever therapy. Int J Clin Pharmacol Ther (2015) 0.79
Inhaled corticosteroids used for the control of asthma in a "real-life" setting do not affect linear growth velocity in prepubertal children. Med Sci Monit (2012) 0.78
Identifying possible asthma-COPD overlap syndrome in patients with a new diagnosis of COPD in primary care. NPJ Prim Care Respir Med (2017) 0.78
Predictive value and utility of oral steroid testing for treatment of COPD in primary care: the COOPT study. Int J Chron Obstruct Pulmon Dis (2009) 0.78
Scientific respiratory symposium, paris june 2010. J Asthma Allergy (2011) 0.77
Inhaler competence and patient satisfaction with Easyhaler®: results of two real-life multicentre studies in asthma and COPD. Drugs R D (2013) 0.77
Chronic obstructive pulmonary disease self-management activation research trial (COPD-SMART): results of recruitment and baseline patient characteristics. Contemp Clin Trials (2015) 0.77
Comparison of Characteristics and Outcomes of Trial Participants and Nonparticipants: Example of Blood and Marrow Transplant Clinical Trials Network 0201 Trial. Biol Blood Marrow Transplant (2015) 0.77
The value of pragmatic and observational studies in health care and public health. Pragmat Obs Res (2017) 0.76
The challenge of recruiting in primary care for a trial of telemonitoring in asthma: an observational study. Pragmat Obs Res (2012) 0.76
Cost-effectiveness of integrated COPD care: the RECODE cluster randomised trial. BMJ Open (2015) 0.76
Add-on LABA in a separate inhaler as asthma step-up therapy versus increased dose of ICS or ICS/LABA combination inhaler. ERJ Open Res (2016) 0.76
Eligibility of real-life patients with COPD for inclusion in RCTs: a commentary. Respir Res (2017) 0.75
Are pharmacological randomised controlled clinical trials relevant to real-life asthma populations? A protocol for an UNLOCK study from the IPCRG. NPJ Prim Care Respir Med (2016) 0.75
2016 Respiratory Effectiveness Group Annual Summit Report-impact & influence of real-world respiratory evidence. J Thorac Dis (2016) 0.75
Time to get real: critical and imperative change required in evidence evaluation. J Thorac Dis (2016) 0.75
Incidence and long-term outcome of severe asthma-COPD overlap compared to asthma and COPD alone: a 35-year prospective study of 57,053 middle-aged adults. Int J Chron Obstruct Pulmon Dis (2017) 0.75
Changes in initial COPD treatment choice over time and factors influencing prescribing decisions in UK primary care: in UK primary care: a real-world, retrospective, observational. NPJ Prim Care Respir Med (2016) 0.75
Randomized controlled trials and real-world observational studies in evaluating cardiovascular safety of inhaled bronchodilator therapy in COPD. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Postapproval Development Options in COPD: A Case Study in Value-Based Healthcare Systems. Am Health Drug Benefits (2011) 0.75
Pragmatic research and outcomes in asthma and COPD. Pragmat Obs Res (2012) 0.75
Systematic Review and Quality Appraisal of Cost-Effectiveness Analyses of Pharmacologic Maintenance Treatment for Chronic Obstructive Pulmonary Disease: Methodological Considerations and Recommendations. Pharmacoeconomics (2017) 0.75
Adding non-randomised studies to a Cochrane review brings complementary information for healthcare stakeholders: an augmented systematic review and meta-analysis. BMC Health Serv Res (2016) 0.75
Doctors and medical science. Australas Med J (2012) 0.75
Representativeness of the participants in the smoking Cessation in Pregnancy Incentives Trial (CPIT): a cross-sectional study. Trials (2016) 0.75
Seinäjoki Adult Asthma Study (SAAS): a protocol for a 12-year real-life follow-up study of new-onset asthma diagnosed at adult age and treated in primary and specialised care. NPJ Prim Care Respir Med (2015) 0.75
Impact of multiple-dose versus single-dose inhaler devices on COPD patients' persistence with long-acting β₂-agonists: a dispensing database analysis. NPJ Prim Care Respir Med (2014) 0.75
Use of electronic medical records and biomarkers to manage risk and resource efficiencies. Eur Clin Respir J (2017) 0.75
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol (2011) 3.35
IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med (2010) 2.36
IL-17A Is Elevated in End-Stage Chronic Obstructive Pulmonary Disease and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis. Am J Respir Crit Care Med (2015) 1.66
Achieving asthma control in practice: understanding the reasons for poor control. Respir Med (2008) 1.61
Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma. J Allergy Clin Immunol (2003) 1.56
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A. Cardiovasc Res (2008) 1.49
ALMA, a new tool for the management of asthma patients in clinical practice: development, validation and initial clinical findings. Prim Care Respir J (2012) 1.41
Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients. Respir Med (2010) 1.41
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol (2010) 1.41
Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane? Respir Res (2006) 1.25
Dysregulated secretoglobin expression in human lung cancers. Lung Cancer (2003) 1.17
Altered fibroblast proteoglycan production in COPD. Respir Res (2010) 1.14
Efficient induction of functional neurons from adult human fibroblasts. Cell Cycle (2011) 1.12
Alterations in lung mast cell populations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 1.12
Maintenance plus reliever budesonide/formoterol compared with a higher maintenance dose of budesonide/formoterol plus formoterol as reliever in asthma: an efficacy and cost-effectiveness study. Curr Med Res Opin (2006) 1.06
Presence of activated mobile fibroblasts in bronchoalveolar lavage from patients with mild asthma. Am J Respir Crit Care Med (2004) 1.05
Fibrocytes and the tissue niche in lung repair. Respir Res (2011) 1.01
Female gender is associated with higher incidence and more stable respiratory symptoms during adolescence. Respir Med (2006) 1.01
Fibrocytes are associated with vascular and parenchymal remodelling in patients with obliterative bronchiolitis. Respir Res (2009) 0.98
Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma. J Allergy Clin Immunol (2011) 0.97
Flow-Volume Parameters in COPD Related to Extended Measurements of Lung Volume, Diffusion, and Resistance. Pulm Med (2013) 0.96
Pathological airway remodelling in inflammation. Clin Respir J (2010) 0.95
Nocturnal temperature controlled laminar airflow for treating atopic asthma: a randomised controlled trial. Thorax (2011) 0.94
Altered matrix production in the distal airways of individuals with asthma. Thorax (2010) 0.93
Activated MCTC mast cells infiltrate diseased lung areas in cystic fibrosis and idiopathic pulmonary fibrosis. Respir Res (2011) 0.92
Effect of montelukast for treatment of asthma in cigarette smokers. J Allergy Clin Immunol (2013) 0.90
Controlled and uncontrolled asthma display distinct alveolar tissue matrix compositions. Respir Res (2014) 0.90
Inflammatory biomarkers in sputum predict COPD exacerbations. Lung (2013) 0.90
Hyperpnea-induced bronchoconstriction and urinary CC16 levels in athletes. Med Sci Sports Exerc (2011) 0.88
dsRNA-induced expression of thymic stromal lymphopoietin (TSLP) in asthmatic epithelial cells is inhibited by a small airway relaxant. Pulm Pharmacol Ther (2010) 0.88
Methodological improvements for measuring eicosanoids and cytokines in exhaled breath condensate. Respir Med (2006) 0.88
Switching from branded to generic inhaled medications: potential impact on asthma and COPD. Expert Opin Drug Deliv (2013) 0.87
Functional and phenotypical comparison of myofibroblasts derived from biopsies and bronchoalveolar lavage in mild asthma and scleroderma. Respir Res (2006) 0.85
Peripheral nitric oxide is increased in rhinitic patients with asthma compared to bronchial hyperresponsiveness. Respir Med (2007) 0.85
Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers. Respir Med (2010) 0.84
TGFβ-induced matrix production by bronchial fibroblasts in asthma: budesonide and formoterol effects. Respir Med (2011) 0.84
Perfusion abnormalities in pulmonary embolism studied with perfusion MRI and ventilation-perfusion scintigraphy: an intra-modality and inter-modality agreement study. J Magn Reson Imaging (2002) 0.84
Specific haptoglobin expression in bronchoalveolar lavage during differentiation of circulating fibroblast progenitor cells in mild asthma. J Proteome Res (2006) 0.83
Allergic rhinitis with hyper-responsiveness differ from asthma in degree of peripheral obstruction during metacholine challenge test. Clin Physiol Funct Imaging (2007) 0.83
Airway hyperresponsiveness to methacholine, adenosine 5-monophosphate, mannitol, eucapnic voluntary hyperpnoea and field exercise challenge in elite cross-country skiers. Br J Sports Med (2010) 0.83
Which biomarkers are effective for identifying Th2-driven inflammation in asthma? Curr Allergy Asthma Rep (2013) 0.83
Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients. J Transl Med (2012) 0.83
Fibroblast phenotypes and their activity are changed in the wound healing process after lung transplantation. J Heart Lung Transplant (2011) 0.83
Elevated levels of activin A in clinical and experimental pulmonary hypertension. J Appl Physiol (1985) (2009) 0.83
Adolescent respiratory symptoms--girls are at risk: the Young-HUNT study, Norway. Respir Med (2005) 0.82
Effects of montelukast and salmeterol on physical performance and exercise economy in adult asthmatics with exercise-induced bronchoconstriction. Chest (2004) 0.82
Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts. Respir Res (2013) 0.82
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice. Am J Physiol Heart Circ Physiol (2006) 0.82
Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation. Am J Physiol Lung Cell Mol Physiol (2011) 0.82
Biomarkers from bronchoalveolar lavage fluid in systemic sclerosis patients with interstitial lung disease relate to severity of lung fibrosis. Respir Med (2013) 0.81
Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma. Am J Respir Cell Mol Biol (2003) 0.81
Comparison of central and peripheral airway involvement before and during methacholine, mannitol and eucapnic hyperventilation challenges in mild asthmatics. Clin Respir J (2011) 0.81
Montelukast in the treatment of asthma and beyond. Expert Rev Clin Immunol (2009) 0.81
Selective inhibition by simvastatin of IRF3 phosphorylation and TSLP production in dsRNA-challenged bronchial epithelial cells from COPD donors. Br J Pharmacol (2013) 0.81
Quality of life in children and adolescents with respiratory allergy, assessed with a generic and disease-specific instrument. Clin Respir J (2013) 0.81
Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction. Thorax (2013) 0.80
Capacity of capsazepinoids to relax human small airways and inhibit TLR3-induced TSLP and IFNβ production in diseased bronchial epithelial cells. Int Immunopharmacol (2012) 0.80
Levels of cysteinyl-leukotrienes in exhaled breath condensate are not due to saliva contamination. Clin Respir J (2010) 0.80
Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings. Ann Agric Environ Med (2003) 0.80
Clinical aspects of using exhaled NO in asthma diagnosis and management. Clin Respir J (2012) 0.80
Midkine is part of the antibacterial activity released at the surface of differentiated bronchial epithelial cells. J Innate Immun (2013) 0.80
Effect of antioxidant supplementation on leucocyte expression of reactive oxygen species in athletes. Scand J Clin Lab Invest (2008) 0.79
Revisiting the role of the mast cell in asthma. Curr Opin Pulm Med (2016) 0.79
Cost effectiveness of adding budesonide/formoterol to tiotropium in COPD in four Nordic countries. Respir Med (2013) 0.78
Inhaled corticosteroid/long-acting β₂-agonist combination therapy for asthma: attitudes of specialists in Europe. Int Arch Allergy Immunol (2011) 0.78
Clinical commentary --COPD is not a systemic disease. Results from the AIMAR Expert Opinion Consensus/Dissensus Seminar "COPD is/is not a systemic disease?", Venice, Italy, 13-14 November 2008. Respir Med (2009) 0.78
Leukotriene receptors are differently expressed in fibroblast from peripheral versus central airways in asthmatics and healthy controls. Prostaglandins Leukot Essent Fatty Acids (2011) 0.78
Collagen VI Is Upregulated in COPD and Serves Both as an Adhesive Target and a Bactericidal Barrier for Moraxella catarrhalis. J Innate Immun (2015) 0.78
[Wasp allergy vaccination]. Tidsskr Nor Laegeforen (2003) 0.78
Increased cysteinyl-leukotrienes and 8-isoprostane in exhaled breath condensate from systemic sclerosis patients. Rheumatology (Oxford) (2010) 0.78
Relationship between matrix production by bronchial fibroblasts and lung function and AHR in asthma. Respir Med (2010) 0.78
Grading obstructive lung disease using tomographic pulmonary scintigraphy in patients with chronic obstructive pulmonary disease (COPD) and long-term smokers. Ann Nucl Med (2014) 0.77
Swedish translation and validation of the Pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ). Acta Paediatr (2010) 0.77
Author correction. Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2-4). Eur Respir J (2015) 0.77
A study of the association between exercise-induced wheeze and exercise versus methacholine-induced bronchoconstriction in adolescents. Pediatr Allergy Immunol (2002) 0.77
IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung. Exp Lung Res (2012) 0.77
Allergy: a systemic disease? The HUNT and Young-HUNT study, Norway. Pediatr Allergy Immunol (2008) 0.77
Methods used in clinical development of novel anti-asthma therapies. Respir Med (2007) 0.76
Glycoproteomic identification of galectin-3 and -8 ligands in bronchoalveolar lavage of mild asthmatics and healthy subjects. Biochim Biophys Acta (2012) 0.76
Marked epithelial cell pathology and leukocyte paucity in persistently symptomatic severe asthma. Am J Respir Crit Care Med (2013) 0.76
Increase of club cell (Clara) protein (CC16) in plasma and urine after exercise challenge in asthmatics and healthy controls, and correlations to exhaled breath temperature and exhaled nitric oxide. Respir Med (2013) 0.76
Use of inhaled corticosteroids and bone mineral density in a population based study: the Nord-Trøndelag Health Study (the HUNT Study). Pharmacoepidemiol Drug Saf (2004) 0.76
Onset of action of formoterol versus salmeterol via dry powder inhalers in moderate chronic obstructive pulmonary disease: a randomized, placebo-controlled, double-blind, crossover study. Clin Drug Investig (2012) 0.76
Extended diagnostic criteria used for indirect challenge testing in elite asthmatic swimmers. Respir Med (2011) 0.76
Urinary CC16 after challenge with dry air hyperpnoea and mannitol in recreational summer athletes. Respir Med (2013) 0.76
Effect of inhaled corticosteroids on forearm bone mineral density: the HUNT study, Norway. Respir Med (2007) 0.75
Disease activity in asthma, more than symptom control and more than eosinophilic inflammation. Clin Respir J (2009) 0.75
Exhaled breath temperature in asthmatics and controls after eucapnic voluntary hyperventilation and a methacholine challenge test. Respiration (2013) 0.75
Exhaled breath temperature increases after exercise in asthmatics and controls. Respiration (2012) 0.75
[International guidelines for allergic rhinitis have been updated]. Lakartidningen (2012) 0.75
Adolescents with wheeze have increased risk of additional health problems. The Young-HUNT study, Norway. Prev Med (2006) 0.75