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1
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Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.
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J Biol Chem
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2005
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1.37
|
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2
|
Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone.
|
J Am Chem Soc
|
2006
|
1.36
|
|
3
|
Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence.
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J Am Chem Soc
|
2009
|
1.16
|
|
4
|
Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.
|
J Am Chem Soc
|
2010
|
1.12
|
|
5
|
Evaluation of penicillin-based inhibitors of the class A and B beta-lactamases from Bacillus anthracis.
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Biochem Biophys Res Commun
|
2004
|
1.08
|
|
6
|
Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.
|
J Biol Chem
|
2008
|
1.07
|
|
7
|
Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies.
|
Org Biomol Chem
|
2006
|
0.96
|
|
8
|
Penicillin sulfone inhibitors of class D beta-lactamases.
|
Antimicrob Agents Chemother
|
2010
|
0.93
|
|
9
|
Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
|
Antimicrob Agents Chemother
|
2011
|
0.92
|
|
10
|
Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase.
|
Biochemistry
|
2007
|
0.91
|
|
11
|
Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226.
|
Antimicrob Agents Chemother
|
2012
|
0.91
|
|
12
|
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
|
Biochemistry
|
2007
|
0.90
|
|
13
|
Evaluation of beta-lactamase inhibitors in disk tests for detection of plasmid-mediated AmpC beta-lactamases in well-characterized clinical strains of Klebsiella spp.
|
J Clin Microbiol
|
2005
|
0.90
|
|
14
|
Efficient inhibition of class A and class D beta-lactamases by Michaelis complexes.
|
J Biol Chem
|
2007
|
0.89
|
|
15
|
Carboxylation and decarboxylation of active site Lys 84 controls the activity of OXA-24 β-lactamase of Acinetobacter baumannii: Raman crystallographic and solution evidence.
|
J Am Chem Soc
|
2012
|
0.86
|
|
16
|
Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase.
|
Antimicrob Agents Chemother
|
2005
|
0.85
|
|
17
|
Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone.
|
Biochem Pharmacol
|
2011
|
0.84
|
|
18
|
Role of E166 in the imine to enamine tautomerization of the clinical beta-lactamase inhibitor sulbactam.
|
Biochemistry
|
2009
|
0.82
|
|
19
|
Early insights into the interactions of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3.
|
Antimicrob Agents Chemother
|
2012
|
0.81
|
|
20
|
Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation.
|
PLoS One
|
2012
|
0.80
|
|
21
|
Approaches to the simultaneous inactivation of metallo- and serine-beta-lactamases.
|
Bioorg Med Chem Lett
|
2009
|
0.79
|
|
22
|
The importance of the trans-enamine intermediate as a β-lactamase inhibition strategy probed in inhibitor-resistant SHV β-lactamase variants.
|
ChemMedChem
|
2012
|
0.79
|
|
23
|
Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy.
|
Bioorg Med Chem Lett
|
2010
|
0.78
|
|
24
|
β-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme.
|
J Am Chem Soc
|
2013
|
0.77
|
|
25
|
Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone.
|
Biochemistry
|
2015
|
0.75
|