1
|
Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.
|
Antimicrob Agents Chemother
|
2002
|
2.59
|
2
|
Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.
|
Antimicrob Agents Chemother
|
2004
|
2.45
|
3
|
Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.
|
Antiviral Res
|
2003
|
2.34
|
4
|
Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model.
|
Virology
|
2004
|
2.32
|
5
|
Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro.
|
Antimicrob Agents Chemother
|
2005
|
1.60
|
6
|
Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.
|
J Infect Dis
|
2004
|
1.55
|
7
|
Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.
|
Antimicrob Agents Chemother
|
2005
|
1.52
|
8
|
Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.
|
J Infect Dis
|
2004
|
1.50
|
9
|
Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir.
|
Antimicrob Agents Chemother
|
2004
|
1.42
|
10
|
Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice.
|
Int J Antimicrob Agents
|
2004
|
1.35
|
11
|
Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.
|
Antimicrob Agents Chemother
|
2004
|
1.30
|
12
|
Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir.
|
Invest Ophthalmol Vis Sci
|
2004
|
1.12
|
13
|
Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O-hexadecylpropanediol-3-phospho-ganciclovir.
|
Invest Ophthalmol Vis Sci
|
2002
|
1.10
|
14
|
Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.
|
Antimicrob Agents Chemother
|
2006
|
1.07
|
15
|
Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.
|
Antimicrob Agents Chemother
|
2007
|
1.03
|
16
|
The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.
|
Antimicrob Agents Chemother
|
2009
|
1.03
|
17
|
Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures.
|
Antimicrob Agents Chemother
|
2006
|
1.02
|
18
|
Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections.
|
Antimicrob Agents Chemother
|
2007
|
0.94
|
19
|
Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro.
|
Antiviral Res
|
2006
|
0.94
|
20
|
Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro.
|
Mol Cancer Ther
|
2006
|
0.92
|
21
|
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
|
Antiviral Res
|
2008
|
0.90
|
22
|
Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig.
|
J Ocul Pharmacol Ther
|
2007
|
0.86
|
23
|
Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir.
|
J Am Chem Soc
|
2011
|
0.86
|
24
|
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
|
Antimicrob Agents Chemother
|
2008
|
0.86
|
25
|
Ganciclovir release rates in vitreous from different formulations of 1-O-hexadecylpropanediol-3-phospho-ganciclovir.
|
J Ocul Pharmacol Ther
|
2003
|
0.86
|
26
|
Antiproliferative property of hexadecyloxypropyl 9-[2-(phosphonomethoxy) ethyl] guanine (HDP-PMEG) for unwanted ocular proliferation.
|
Mol Vis
|
2011
|
0.85
|
27
|
Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.
|
Antimicrob Agents Chemother
|
2006
|
0.85
|
28
|
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
|
Antimicrob Agents Chemother
|
2009
|
0.85
|
29
|
Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice.
|
Antiviral Res
|
2006
|
0.85
|
30
|
In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.
|
Antiviral Res
|
2006
|
0.82
|
31
|
Intraocular properties of hexadecyloxypropyl-cyclic-cidofovir in Guinea pigs.
|
J Ocul Pharmacol Ther
|
2005
|
0.82
|
32
|
Intraocular pharmacokinetics of a crystalline lipid prodrug, octadecyloxyethyl-cyclic-cidofovir, for cytomegalovirus retinitis.
|
J Ocul Pharmacol Ther
|
2011
|
0.82
|
33
|
Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine.
|
Antivir Chem Chemother
|
2006
|
0.82
|
34
|
A novel cytarabine crystalline lipid prodrug: hexadecyloxypropyl cytarabine 3',5'-cyclic monophosphate for proliferative vitreoretinopathy.
|
Mol Vis
|
2012
|
0.81
|
35
|
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
|
Antiviral Res
|
2006
|
0.81
|
36
|
Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses.
|
Antiviral Res
|
2009
|
0.80
|
37
|
Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection.
|
Antimicrob Agents Chemother
|
2010
|
0.80
|
38
|
Anti-BK virus activity of nucleoside analogs.
|
Antimicrob Agents Chemother
|
2008
|
0.79
|
39
|
Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication.
|
Bioorg Med Chem
|
2011
|
0.79
|
40
|
Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates.
|
Bioorg Med Chem
|
2006
|
0.79
|
41
|
Intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV) as a long-lasting intravitreal antiviral drug.
|
Invest Ophthalmol Vis Sci
|
2011
|
0.78
|
42
|
Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action.
|
Antimicrob Agents Chemother
|
2011
|
0.77
|
43
|
Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine.
|
Bioorg Med Chem
|
2011
|
0.76
|
44
|
Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.
|
Antimicrob Agents Chemother
|
2009
|
0.75
|
45
|
Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo.
|
Chemotherapy
|
2010
|
0.75
|