|
1
|
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.
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Science
|
2007
|
12.41
|
|
2
|
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.
|
Cell
|
2004
|
5.27
|
|
3
|
Global reorganization of replication domains during embryonic stem cell differentiation.
|
PLoS Biol
|
2008
|
4.50
|
|
4
|
SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation.
|
Nat Med
|
2008
|
3.02
|
|
5
|
Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia.
|
Oncogene
|
2005
|
2.50
|
|
6
|
KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.
|
Nat Genet
|
2010
|
2.39
|
|
7
|
Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.
|
Cell Stem Cell
|
2012
|
2.11
|
|
8
|
Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells.
|
Stem Cells
|
2009
|
2.01
|
|
9
|
Correction of sickle cell disease by homologous recombination in embryonic stem cells.
|
Blood
|
2006
|
1.92
|
|
10
|
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.
|
Blood
|
2002
|
1.88
|
|
11
|
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo.
|
J Exp Med
|
2008
|
1.86
|
|
12
|
Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells.
|
Blood
|
2003
|
1.76
|
|
13
|
Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization.
|
J Biol Chem
|
2002
|
1.42
|
|
14
|
Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.
|
J Biol Chem
|
2004
|
1.42
|
|
15
|
PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.
|
Stem Cells
|
2011
|
1.37
|
|
16
|
Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.
|
Mol Cell Biol
|
2006
|
1.26
|
|
17
|
Differential binding of erythroid Krupple-like factor to embryonic/fetal globin gene promoters during development.
|
J Biol Chem
|
2006
|
1.26
|
|
18
|
Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1.
|
J Biol Chem
|
2002
|
1.17
|
|
19
|
Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis.
|
Blood
|
2012
|
1.15
|
|
20
|
Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection.
|
Mol Cell Biol
|
2011
|
1.13
|
|
21
|
Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene.
|
Cancer Res
|
2004
|
1.03
|
|
22
|
A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin.
|
J Biol Chem
|
2004
|
1.02
|
|
23
|
Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.
|
Nucleic Acids Res
|
2004
|
1.01
|
|
24
|
USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.
|
Genes Dev
|
2013
|
1.01
|
|
25
|
Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses.
|
J Immunol
|
2010
|
1.00
|
|
26
|
SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency.
|
Proc Natl Acad Sci U S A
|
2012
|
0.99
|
|
27
|
Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
|
Chem Biol
|
2003
|
0.88
|
|
28
|
FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin.
|
J Clin Invest
|
2012
|
0.88
|
|
29
|
Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen.
|
Biol Blood Marrow Transplant
|
2002
|
0.81
|
|
30
|
Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species.
|
Br J Pharmacol
|
2016
|
0.79
|