PubRank

Pál Pacher

Author PubWeight™ 151.41‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov 2008 4.76
2 Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest 2005 4.55
3 Activation of the peripheral endocannabinoid system in human obesity. Diabetes 2005 2.90
4 NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov 2006 2.84
5 Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat Protoc 2007 2.84
6 Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol 2007 2.81
7 Simple quantitative detection of mitochondrial superoxide production in live cells. Biochem Biophys Res Commun 2007 2.51
8 Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation 2011 2.48
9 Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes 2006 2.40
10 Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation 2004 2.15
11 CD39 and CD73 in immunity and inflammation. Trends Mol Med 2013 2.08
12 Evidence for novel cannabinoid receptors. Pharmacol Ther 2005 2.00
13 Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J Immunol 2005 1.98
14 Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J 2007 1.94
15 Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 2008 1.90
16 Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am J Physiol Heart Circ Physiol 2009 1.89
17 Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. Am J Physiol Heart Circ Physiol 2004 1.88
18 Shaping of monocyte and macrophage function by adenosine receptors. Pharmacol Ther 2006 1.82
19 CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol Heart Circ Physiol 2007 1.77
20 A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli. Blood 2007 1.76
21 Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. J Biol Chem 2003 1.70
22 Immunity, inflammation and cancer: a leading role for adenosine. Nat Rev Cancer 2013 1.69
23 A2A receptors in inflammation and injury: lessons learned from transgenic animals. J Leukoc Biol 2007 1.68
24 Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock 2003 1.64
25 Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst. Mol Med 2002 1.62
26 Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol 2010 1.56
27 Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Am J Physiol Heart Circ Physiol 2007 1.54
28 Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation 2002 1.52
29 Investigational A₃ adenosine receptor targeting agents. Expert Opin Investig Drugs 2011 1.49
30 A(2B) adenosine receptors in immunity and inflammation. Trends Immunol 2009 1.48
31 The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis. Eur J Pharmacol 2003 1.48
32 Parenteral administration of glipizide sodium salt, an inhibitor of adenosine triphosphate-sensitive potassium channels, prolongs short-term survival after severe controlled hemorrhage in rats. Crit Care Med 2003 1.46
33 Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. Shock 2002 1.44
34 Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis. J Immunol 2006 1.43
35 Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. Curr Vasc Pharmacol 2005 1.42
36 Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. J Leukoc Biol 2007 1.39
37 Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J 2011 1.38
38 Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy. Free Radic Biol Med 2009 1.38
39 Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic Biol Med 2011 1.36
40 Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol 2007 1.34
41 A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation. J Immunol 2010 1.33
42 Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation. Am J Respir Crit Care Med 2002 1.31
43 Adenosine receptor activation ameliorates type 1 diabetes. FASEB J 2007 1.27
44 Adenosine receptor signaling in the brain immune system. Trends Pharmacol Sci 2005 1.25
45 Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death. Free Radic Biol Med 2011 1.24
46 Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. J Pharmacol Exp Ther 2008 1.24
47 G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. J Biol Chem 2003 1.24
48 Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation. Circ Res 2002 1.23
49 Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats. Am J Physiol Heart Circ Physiol 2007 1.22
50 CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. Cardiovasc Res 2009 1.22
51 CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. Br J Pharmacol 2010 1.18
52 Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity. Oncol Rep 2004 1.18
53 Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation. FASEB J 2004 1.17
54 Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis. J Immunol 2011 1.16
55 Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function. FASEB J 2008 1.16
56 Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide. Infect Immun 2002 1.13
57 Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock 2004 1.13
58 Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression. Int J Mol Med 2004 1.13
59 Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation. Mol Med 2004 1.11
60 Regulation of macrophage function by adenosine. Arterioscler Thromb Vasc Biol 2012 1.11
61 Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes 2012 1.10
62 Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis. Gastroenterology 2007 1.09
63 Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol Cell Biol 2009 1.09
64 Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury. Ann Surg 2002 1.07
65 Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy. J Cell Mol Med 2008 1.05
66 Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J Histochem Cytochem 2012 1.05
67 A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury. Br J Pharmacol 2012 1.04
68 Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis. Biochem Biophys Res Commun 2006 1.04
69 Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury. Free Radic Biol Med 2011 1.03
70 Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. Med Sci Monit 2004 1.03
71 Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization. Alcohol Clin Exp Res 2005 1.02
72 Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants. Free Radic Biol Med 2012 1.02
73 Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury. Free Radic Biol Med 2010 1.01
74 Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death. FASEB J 2010 1.00
75 Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure. Biochem Pharmacol 2005 0.99
76 The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends Pharmacol Sci 2009 0.99
77 Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. Br J Pharmacol 2010 0.97
78 Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation. Biochem Biophys Res Commun 2008 0.96
79 Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation. Mol Med 2002 0.96
80 Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy. J Nutr Biochem 2011 0.95
81 Electrophysiological effects of risperidone in mammalian cardiac cells. Naunyn Schmiedebergs Arch Pharmacol 2002 0.94
82 Adenosine augments IL-10 production by microglial cells through an A2B adenosine receptor-mediated process. J Immunol 2011 0.94
83 CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis. PLoS One 2009 0.94
84 Poly(ADP-ribose)polymerase inhibition decreases angiogenesis. Biochem Biophys Res Commun 2006 0.93
85 Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis. Mol Med 2002 0.93
86 Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes. Mol Med 2003 0.93
87 Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. Gastroenterology 2013 0.92
88 Cannabinoid CB1 receptor antagonists for atherosclerosis and cardiometabolic disorders: new hopes, old concerns? Arterioscler Thromb Vasc Biol 2009 0.90
89 Cannabinoids cool the intestine. Nat Med 2004 0.90
90 A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation. Diabetes 2013 0.90
91 Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis. Am J Physiol Gastrointest Liver Physiol 2002 0.90
92 The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications. Am J Pathol 2011 0.89
93 Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase. Life Sci 2004 0.89
94 Female X-chromosome mosaicism for NOX2 deficiency presents unique inflammatory phenotype and improves outcome in polymicrobial sepsis. J Immunol 2011 0.88
95 Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors. Br J Pharmacol 2012 0.88
96 Targeting cannabinoid receptor CB(2) in cardiovascular disorders: promises and controversies. Br J Pharmacol 2012 0.86
97 Role of A(2A) adenosine receptors in regulation of opsonized E. coli-induced macrophage function. Purinergic Signal 2007 0.86
98 Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol 2013 0.86
99 β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. Free Radic Biol Med 2012 0.85
100 Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D. Int J Mol Med 2007 0.85
101 Endocannabinoids and cardiac contractile function: pathophysiological implications. Pharmacol Res 2009 0.84
102 Endothelial Nrf2 activation: a new target for resveratrol? Am J Physiol Heart Circ Physiol 2010 0.84
103 CB1 cannabinoid receptor inhibition: promising approach for heart failure? Congest Heart Fail 2008 0.82
104 Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes. Mol Med Rep 2010 0.82
105 Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes. J Invest Dermatol 2003 0.80
106 Pleiotropic effects of the CB2 cannabinoid receptor activation on human monocyte migration: implications for atherosclerosis and inflammatory diseases. Am J Physiol Heart Circ Physiol 2008 0.80
107 Differential effects of fluoxetine enantiomers in mammalian neural and cardiac tissues. Int J Mol Med 2003 0.79
108 Soluble guanylate cyclase agonists inhibit expression and procoagulant activity of tissue factor. Arterioscler Thromb Vasc Biol 2009 0.78
109 Interplay of cannabinoid 2 (CB2) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegeneration. J Mol Med (Berl) 2012 0.78
110 Peripheral endocannabinoid system activity in patients treated with sibutramine. Obesity (Silver Spring) 2008 0.78
111 Stimulation of A2B adenosine receptors protects against trauma-hemorrhagic shock-induced lung injury. Purinergic Signal 2013 0.78
112 Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways. Mutat Res 2004 0.78
113 Role of nonsynaptic communication in regulating the immune response. Neurochem Int 2007 0.77
114 Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation. PLoS One 2013 0.76
115 Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro. Int J Mol Med 2013 0.75
116 Suppression of tumorigenicity 2: a janus-faced player in sepsis. Am J Respir Crit Care Med 2011 0.75
117 Dysregulation of nitric oxide (NO). Curr Vasc Pharmacol 2005 0.75