Published in Basic Clin Pharmacol Toxicol on February 01, 2005
MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. PLoS One (2016) 1.45
Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. Phytother Res (2010) 1.07
Molecular determinants of local anesthetic action of beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3. J Mol Cell Cardiol (2009) 1.05
Modification of K+ channel-drug interactions by ancillary subunits. J Physiol (2007) 1.04
KCNE2 and the K (+) channel: the tail wagging the dog. Channels (Austin) (2012) 0.84
Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol (2006) 0.81
The KCNH2 genetic polymorphism (1956, C>T) is a novel biomarker that is associated with CCB and α,β-ADR blocker response in EH patients in China. PLoS One (2013) 0.77
Torsades de pointes induced by concomitant use of chlorpheniramine and propranolol: An unusual presentation with no QT prolongation. Indian J Pharmacol (2016) 0.75
Control of the heart rate of rat embryos during the organogenic period. Hypoxia (Auckl) (2016) 0.75
Electrophysiological Characteristics of the LQT2 Syndrome Mutation KCNH2-G572S and Regulation by Accessory Protein KCNE2. Front Physiol (2016) 0.75
Single-copy insertion of transgenes in Caenorhabditis elegans. Nat Genet (2008) 7.58
The KCNQ1 potassium channel: from gene to physiological function. Physiology (Bethesda) (2005) 2.11
The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc Res (2007) 2.03
Contribution of Kv7 channels to basal coronary flow and active response to ischemia. Hypertension (2013) 1.70
KCNE4 is an inhibitory subunit to the KCNQ1 channel. J Physiol (2002) 1.70
NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytes. Pflugers Arch (2005) 1.64
Identification of a Kir3.4 mutation in congenital long QT syndrome. Am J Hum Genet (2010) 1.57
Pharmacological activation of IKr impairs conduction in guinea pig hearts. J Cardiovasc Electrophysiol (2010) 1.50
Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol (2005) 1.43
Mobility of ions, sugar, and water in the cytoplasm of Xenopus oocytes expressing Na(+)-coupled sugar transporters (SGLT1). J Physiol (2002) 1.41
The phenotype characteristics of type 13 long QT syndrome with mutation in KCNJ5 (Kir3.4-G387R). Heart Rhythm (2013) 1.40
Aquaporin homologues in plants and mammals transport ammonia. FEBS Lett (2004) 1.39
Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment. J Cell Sci (2007) 1.39
KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. Biophys J (2002) 1.39
KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval. Heart Rhythm (2007) 1.39
Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc Res (2010) 1.38
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol Pharmacol (2005) 1.37
BK channel modulators: a comprehensive overview. Curr Med Chem (2008) 1.35
Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts. Pflugers Arch (2009) 1.20
The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels. Neuropharmacology (2006) 1.19
High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation. Circ Cardiovasc Genet (2012) 1.17
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia. Physiol Rev (2014) 1.14
KCNQ1 channels sense small changes in cell volume. J Physiol (2003) 1.13
The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes. Brain Res Mol Brain Res (2005) 1.13
A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation. Cardiovasc Res (2013) 1.11
The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol (2007) 1.11
KCNE3 mutation V17M identified in a patient with lone atrial fibrillation. Cell Physiol Biochem (2008) 1.09
Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome. Heart Rhythm (2005) 1.08
Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current. Pflugers Arch (2008) 1.07
KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. Biochem Biophys Res Commun (2006) 1.05
Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury. Pflugers Arch (2008) 1.05
BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am J Physiol Regul Integr Comp Physiol (2009) 1.03
KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels. Biophys J (2003) 1.03
Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif. J Cell Sci (2004) 1.01
Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation. Eur Heart J (2012) 1.01
Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol Pharmacol (2006) 1.01
hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics. Biochem Biophys Res Commun (2005) 1.00
Regulation of cloned, Ca2+-activated K+ channels by cell volume changes. Pflugers Arch (2002) 1.00
Modulation of KCNQ4 channel activity by changes in cell volume. Biochim Biophys Acta (2004) 0.99
Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2. Am J Physiol Cell Physiol (2006) 0.98
A new family of insect tyramine receptors. Biochem Biophys Res Commun (2005) 0.96
Differential effects of the transient outward K(+) current activator NS5806 in the canine left ventricle. J Mol Cell Cardiol (2009) 0.96
Inactivation as a new regulatory mechanism for neuronal Kv7 channels. Biophys J (2007) 0.95
A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. J Biol Chem (2013) 0.95
Cell volume and membrane stretch independently control K+ channel activity. J Physiol (2009) 0.95
Familial aggregation of lone atrial fibrillation in young persons. J Am Coll Cardiol (2012) 0.94
Physiological consequences of transient outward K+ current activation during heart failure in the canine left ventricle. J Mol Cell Cardiol (2012) 0.94
The genetic component of Brugada syndrome. Front Physiol (2013) 0.94
Modulation of ERG channels by XE991. Basic Clin Pharmacol Toxicol (2007) 0.93
Differential expression of BK channel isoforms and beta-subunits in rat neuro-vascular tissues. Biochim Biophys Acta (2008) 0.93
hERG1 channel activators: a new anti-arrhythmic principle. Prog Biophys Mol Biol (2009) 0.93
Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart. Am J Physiol Heart Circ Physiol (2003) 0.93
The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels? Biochem Biophys Res Commun (2006) 0.92
The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia. Biochim Biophys Acta (2003) 0.92
Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption. Proc Natl Acad Sci U S A (2008) 0.92
Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics. PLoS One (2010) 0.90
Molecular cloning of a K(+) channel from the malaria parasite Plasmodium falciparum. Biochem Biophys Res Commun (2004) 0.89
Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. J Pharmacol Exp Ther (2007) 0.89
Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients. Biochem Biophys Res Commun (2007) 0.88
Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. Heart Rhythm (2011) 0.87
Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice. J Cardiovasc Electrophysiol (2014) 0.86
AMP-activated protein kinase downregulates Kv7.1 cell surface expression. Traffic (2011) 0.86
Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colon. Pflugers Arch (2003) 0.86
Comparison of the effects of a transient outward potassium channel activator on currents recorded from atrial and ventricular cardiomyocytes. J Cardiovasc Electrophysiol (2011) 0.86
In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig. J Cardiovasc Pharmacol (2008) 0.85
Kv7.1 surface expression is regulated by epithelial cell polarization. Am J Physiol Cell Physiol (2011) 0.85
PIP₂ modulation of Slick and Slack K⁺ channels. Biochem Biophys Res Commun (2012) 0.85
Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons. J Biol Chem (2014) 0.84
Activation of ERG2 potassium channels by the diphenylurea NS1643. Neuropharmacology (2007) 0.84
Tissue-specific effects of acetylcholine in the canine heart. Am J Physiol Heart Circ Physiol (2013) 0.84
Functional properties of human neuronal Kv11 channels. Pflugers Arch (2009) 0.82
Development of heart failure is independent of K+ channel-interacting protein 2 expression. J Physiol (2013) 0.82
Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352. Pflugers Arch (2003) 0.81
Clofilium inhibits Slick and Slack potassium channels. Biologics (2012) 0.81
Keeping the rhythm -- pro-arrhythmic investigations in isolated Göttingen minipig hearts. J Pharmacol Toxicol Methods (2011) 0.81
G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization. Cardiovasc Res (2013) 0.81
Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels. Pflugers Arch (2003) 0.81
High throughput electrophysiology: new perspectives for ion channel drug discovery. Receptors Channels (2003) 0.80
Cell swelling activates cloned Ca(2+)-activated K(+) channels: a role for the F-actin cytoskeleton. Biochim Biophys Acta (2003) 0.80
Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state. Biophys J (2011) 0.79
Characterization of two new dominant ClC-1 channel mutations associated with myotonia. Muscle Nerve (2003) 0.79
P2Y2 and P2Y4 receptors regulate pancreatic Ca(2+)-activated K+ channels differently. Pflugers Arch (2005) 0.79
Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model. Heart Rhythm (2008) 0.79
GIRK channel activation via adenosine or muscarinic receptors has similar effects on rat atrial electrophysiology. J Cardiovasc Pharmacol (2013) 0.79
Trafficking of the IKs -complex in MDCK cells: site of subunit assembly and determinants of polarized localization. Traffic (2013) 0.78
Quantification and distribution of big conductance Ca2+-activated K+ channels in kidney epithelia. Biochim Biophys Acta (2005) 0.78
Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.78
K(Ca)3.1 channel downregulation and impaired endothelium-derived hyperpolarization-type relaxation in pulmonary arteries from chronically hypoxic rats. Exp Physiol (2012) 0.77
A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1. Pflugers Arch (2003) 0.77