The mediator of RNA polymerase II.

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46

A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev (2006) 2.29

The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene. J Med Genet (2007) 2.02

The selection and function of cell type-specific enhancers. Nat Rev Mol Cell Biol (2015) 1.93

Fat synthesis and adiposity regulation in Caenorhabditis elegans. Trends Endocrinol Metab (2009) 1.91

CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell (2008) 1.66

Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. J Invest Dermatol (2011) 1.64

A Mediator-responsive form of metazoan RNA polymerase II. Proc Natl Acad Sci U S A (2006) 1.58

Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol (2007) 1.50

Interaction of Bunyamwera Orthobunyavirus NSs protein with mediator protein MED8: a mechanism for inhibiting the interferon response. J Virol (2006) 1.36

The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc Natl Acad Sci U S A (2005) 1.31

The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A (2006) 1.30

The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. PLoS Genet (2008) 1.29

Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. J Invest Dermatol (2008) 1.24

Enhancer responses to similarly distributed antagonistic gradients in development. PLoS Comput Biol (2007) 1.21

Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proc Natl Acad Sci U S A (2010) 1.14

Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol Cell Biol (2005) 1.13

Mediator-dependent nuclear receptor function. Semin Cell Dev Biol (2011) 1.12

RNA polymerase II C-terminal heptarepeat domain Ser-7 phosphorylation is established in a mediator-dependent fashion. J Biol Chem (2009) 1.12

Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration. Cerebellum (2008) 1.11

The new core promoter element XCPE1 (X Core Promoter Element 1) directs activator-, mediator-, and TATA-binding protein-dependent but TFIID-independent RNA polymerase II transcription from TATA-less promoters. Mol Cell Biol (2007) 1.11

Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells. J Virol (2011) 1.00

Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. J Biol Chem (2011) 0.98

The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation. J Invest Dermatol (2010) 0.97

Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. Proc Natl Acad Sci U S A (2010) 0.95

Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev (2012) 0.94

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit. Nat Struct Mol Biol (2014) 0.94

The interactome of the human respiratory syncytial virus NS1 protein highlights multiple effects on host cell biology. J Virol (2012) 0.94

Enhancer-promoter communication and transcriptional regulation of Igh. Trends Immunol (2011) 0.92

An activation domain within the walleye dermal sarcoma virus retroviral cyclin protein is essential for inhibition of the viral promoter. Virology (2005) 0.91

Walleye dermal sarcoma virus retroviral cyclin directly contacts TAF9. J Virol (2006) 0.90

The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses. Viruses (2011) 0.90

Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis. PLoS One (2013) 0.88

Genomic expression patterns in cell separation mutants of Schizosaccharomyces pombe defective in the genes sep10 ( + ) and sep15 ( + ) coding for the Mediator subunits Med31 and Med8. Mol Genet Genomics (2007) 0.85

Characterization of the heart transcriptome of the white shark (Carcharodon carcharias). BMC Genomics (2013) 0.78

Screening and identification of host factors interacting with UL14 of herpes simplex virus 1. Med Microbiol Immunol (2011) 0.77

Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Dev Genes Evol (2015) 0.76

PIC Activation through Functional Interplay between Mediator and TFIIH. J Mol Biol (2016) 0.75

Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62

A protein interaction map of Drosophila melanogaster. Science (2003) 20.06

Selective and accurate initiation of transcription at the Ad2 major late promotor in a soluble system dependent on purified RNA polymerase II and DNA. Cell (1979) 19.98

Multiple factors required for accurate initiation of transcription by purified RNA polymerase II. J Biol Chem (1980) 10.78

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell (2003) 10.42

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44

Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell (1990) 8.18

The general transcription factors of RNA polymerase II. Genes Dev (1996) 7.15

Mutants of yeast defective in sucrose utilization. Genetics (1981) 6.20

Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae. Genetics (1984) 6.09

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. Cell (1991) 6.04

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell (1993) 5.35

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature (1999) 4.40

Five SWI genes are required for expression of the HO gene in yeast. J Mol Biol (1984) 4.20

Transcriptional coactivator complexes. Annu Rev Biochem (2001) 3.97

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus. Cell (1990) 3.74

A transcription reinitiation intermediate that is stabilized by activator. Nature (2000) 3.65

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc Natl Acad Sci U S A (1996) 3.61

Structure, function, and activator-induced conformations of the CRSP coactivator. Science (2002) 3.52

Mediator of transcriptional regulation. Annu Rev Biochem (2000) 3.51

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell (1999) 3.47

Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature (2002) 3.42

Activation of class II gene transcription by regulatory factors is potentiated by a novel activity. Cell (1991) 3.36

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol Cell (2004) 3.34

Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors. Cell (1990) 3.31

Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II. Genetics (1989) 3.04

Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells. Trends Biochem Sci (2000) 3.03

A mediator required for activation of RNA polymerase II transcription in vitro. Nature (1991) 3.00

Dynamics of enhancer-promoter communication during differentiation-induced gene activation. Mol Cell (2002) 2.94

Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB. Genes Dev (1999) 2.94

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev (1998) 2.91

The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A (1998) 2.76

TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature (2000) 2.76

Ty-mediated gene expression of the LYS2 and HIS4 genes of Saccharomyces cerevisiae is controlled by the same SPT genes. Proc Natl Acad Sci U S A (1984) 2.75

Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J Biol Chem (2002) 2.68

Independent recruitment in vivo by Gal4 of two complexes required for transcription. Mol Cell (2003) 2.48

GAL11 protein, an auxiliary transcription activator for genes encoding galactose-metabolizing enzymes in Saccharomyces cerevisiae. Mol Cell Biol (1988) 2.41

Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell (2000) 2.39

Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science (2002) 2.33

NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. Mol Cell (1998) 2.33

Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction. Mol Cell (2002) 2.32

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro. Genes Dev (1998) 2.27

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J (1999) 2.24

Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell (2002) 2.24

A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res (2004) 2.15

Regulatory diversity among metazoan co-activator complexes. Nat Rev Mol Cell Biol (2004) 2.10

Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1987) 2.10

Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem (1997) 2.10

Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev (2002) 2.02

Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Mol Cell (2001) 2.00

Ras induces mediator complex exchange on C/EBP beta. Mol Cell (2004) 1.98

Conserved structures of mediator and RNA polymerase II holoenzyme. Science (1999) 1.97

Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF. Mol Cell (2001) 1.93

Mediator complexes and transcription. Curr Opin Cell Biol (2001) 1.91

Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86

A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast. J Biol Chem (2002) 1.84

LALNVIEW: a graphical viewer for pairwise sequence alignments. Comput Appl Biosci (1996) 1.83

A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature (2002) 1.82

A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. EMBO J (1996) 1.81

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J (2003) 1.78

Structural organization of yeast and mammalian mediator complexes. Proc Natl Acad Sci U S A (2000) 1.76

A recombinant RNA polymerase II-like enzyme capable of promoter-specific transcription. Mol Cell (2002) 1.76

Selective coactivator interactions in gene activation by SREBP-1a and -1c. Mol Cell Biol (2004) 1.75

The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc Natl Acad Sci U S A (2002) 1.72

The structural and functional organization of the yeast mediator complex. J Biol Chem (2001) 1.71

The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. Proc Natl Acad Sci U S A (2004) 1.70

Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme. Mol Cell Biol (1998) 1.69

Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. EMBO Rep (2001) 1.67

A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J Biol Chem (2002) 1.66

The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. Mol Cell (2000) 1.65

Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc Natl Acad Sci U S A (1999) 1.54

Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol (2003) 1.53

An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p. Mol Cell Biol (2004) 1.51

TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA. Genes Dev (2002) 1.45

Yeast nuclear extract contains two major forms of RNA polymerase II mediator complexes. J Biol Chem (2001) 1.42

The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J (2002) 1.38

SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res (2002) 1.38

Distinct conformational states of nuclear receptor-bound CRSP-Med complexes. Nat Struct Mol Biol (2004) 1.35

Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev (2000) 1.34

RNA polymerase II cofactor PC2 facilitates activation of transcription by GAL4-AH in vitro. Mol Cell Biol (1994) 1.34

Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA. Mol Cell Biol (2003) 1.33

TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol (2002) 1.31

Coactivators for the orphan nuclear receptor RORalpha. Mol Endocrinol (1999) 1.23

Role of metazoan mediator proteins in interferon-responsive transcription. Mol Cell Biol (2003) 1.22

The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo. Mol Microbiol (2000) 1.21

Differential recruitment of the mammalian mediator subunit TRAP220 by estrogen receptors ERalpha and ERbeta. J Biol Chem (2001) 1.21

Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proc Natl Acad Sci U S A (1997) 1.20

Targeting of Swi/Snf to the yeast GAL1 UAS G requires the Mediator, TAF IIs, and RNA polymerase II. EMBO J (2004) 1.20

Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. J Biol Chem (2000) 1.19

Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters. Mol Cell Biol (2001) 1.16

Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors. Mol Cell Biol (2003) 1.16

Mediator and p300/CBP-steroid receptor coactivator complexes have distinct roles, but function synergistically, during estrogen receptor alpha-dependent transcription with chromatin templates. Mol Cell Biol (2003) 1.12

Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. J Biol Chem (1998) 1.11

intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Development (2002) 1.10

A single point mutation in TFIIA suppresses NC2 requirement in vivo. EMBO J (2000) 1.10

MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Proc Natl Acad Sci U S A (2004) 1.09

Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro. J Biol Chem (2003) 1.09

RNA polymerase II (Pol II)-TFIIF and Pol II-mediator complexes: the major stable Pol II complexes and their activity in transcription initiation and reinitiation. Mol Cell Biol (2004) 1.05

Retracted BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220. Oncogene (2004) 1.03

Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science (2007) 4.18

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. Nat Methods (2004) 2.35

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J (2003) 1.78

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78

Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol (2003) 1.53

Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev (2010) 1.44

Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. Cell (2013) 1.40

NC2 mobilizes TBP on core promoter TATA boxes. Nat Struct Mol Biol (2007) 1.30

Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells. J Exp Med (2006) 1.29

The H1 and H2 regions of the activation domain of herpes simplex virion protein 16 stimulate transcription through distinct molecular mechanisms. Genes Cells (2002) 1.25

RNA polymerase II C-terminal heptarepeat domain Ser-7 phosphorylation is established in a mediator-dependent fashion. J Biol Chem (2009) 1.12

Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Neurogenetics (2009) 1.10

The VP16 activation domain establishes an active mediator lacking CDK8 in vivo. J Biol Chem (2006) 1.10

Global distribution of negative cofactor 2 subunit-alpha on human promoters. Proc Natl Acad Sci U S A (2007) 1.08

Structure and VP16 binding of the Mediator Med25 activator interaction domain. Nat Struct Mol Biol (2011) 1.08

Efficient binding of NC2.TATA-binding protein to DNA in the absence of TATA. J Biol Chem (2004) 1.06

Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae. Mol Cell (2013) 1.05

TATA-binding protein-free TAF-containing complex (TFTC) and p300 are both required for efficient transcriptional activation. J Biol Chem (2002) 1.01

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription. Elife (2014) 1.01

NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein. Mol Cell Biol (2004) 0.99

Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites. J Cell Biol (2008) 0.96

Transcriptional coactivator PC4 stimulates promoter escape and facilitates transcriptional synergy by GAL4-VP16. Mol Cell Biol (2004) 0.95

Kaposi's sarcoma-associated herpesvirus Lana-1 is a major activator of the serum response element and mitogen-activated protein kinase pathways via interactions with the Mediator complex. J Gen Virol (2010) 0.94

Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. Immunity (2010) 0.92

The quantitative nuclear matrix proteome as a biochemical snapshot of nuclear organization. J Proteome Res (2014) 0.91

Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia. Am J Med Genet B Neuropsychiatr Genet (2003) 0.89

RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway. Biochim Biophys Acta (2013) 0.87

Overcoming bottlenecks of enzymatic biofuel cell cathodes: crude fungal culture supernatant can help to extend lifetime and reduce cost. ChemSusChem (2013) 0.84

Conserved CPEs in the p53 3' untranslated region influence mRNA stability and protein synthesis. Anticancer Res (2008) 0.84

Regulation of nuclear import and export of negative cofactor 2. J Biol Chem (2009) 0.83

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells. BMC Cancer (2013) 0.82

Control of gene transcription by Mediator in chromatin. Semin Cell Dev Biol (2011) 0.82

IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. Sci Rep (2015) 0.81

Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells. Genome Biol (2010) 0.80

A functional proteomics approach for the detection of nuclear proteins based on derepressed importin alpha. Proteomics (2006) 0.79

Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1. Int J Cancer (2014) 0.79

Corrigendum: IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. Sci Rep (2016) 0.75

TFII-IDelta and TFII-Ibeta: unequal brothers fostering cellular proliferation. Mol Cell (2006) 0.75

A comprehensive Proteomic Investigation of Ebf1 Heterozygosity in pro-B lymphocytes utilizing Data Independent Acquisition (DIA). J Proteome Res (2017) 0.75