1
|
Vorinostat.
|
Nat Rev Drug Discov
|
2007
|
2.83
|
2
|
Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress.
|
Circ Res
|
2006
|
2.58
|
3
|
Abatacept.
|
Nat Rev Drug Discov
|
2006
|
2.13
|
4
|
Pegloticase.
|
Nat Rev Drug Discov
|
2011
|
1.76
|
5
|
Vemurafenib.
|
Nat Rev Drug Discov
|
2011
|
1.68
|
6
|
Tetrabenazine.
|
Nat Rev Drug Discov
|
2009
|
1.60
|
7
|
Eculizumab.
|
Nat Rev Drug Discov
|
2007
|
1.56
|
8
|
Dabigatran etexilate.
|
Nat Rev Drug Discov
|
2008
|
1.41
|
9
|
Sipuleucel-T.
|
Nat Rev Drug Discov
|
2010
|
1.37
|
10
|
Tocilizumab.
|
Nat Rev Drug Discov
|
2009
|
1.36
|
11
|
Effect of decompressive craniectomy on intracranial pressure and cerebrospinal compensation following traumatic brain injury.
|
J Neurosurg
|
2008
|
1.35
|
12
|
Cabazitaxel.
|
Nat Rev Drug Discov
|
2010
|
1.34
|
13
|
Denosumab.
|
Nat Rev Drug Discov
|
2010
|
1.31
|
14
|
Cetuximab.
|
Nat Rev Drug Discov
|
2004
|
1.31
|
15
|
Panitumumab.
|
Nat Rev Drug Discov
|
2006
|
1.31
|
16
|
Everolimus.
|
Nat Rev Drug Discov
|
2009
|
1.29
|
17
|
Liraglutide.
|
Nat Rev Drug Discov
|
2010
|
1.27
|
18
|
Dasatinib.
|
Nat Rev Drug Discov
|
2006
|
1.25
|
19
|
Azacitidine.
|
Nat Rev Drug Discov
|
2005
|
1.23
|
20
|
Enfuvirtide.
|
Nat Rev Drug Discov
|
2003
|
1.22
|
21
|
Daptomycin.
|
Nat Rev Drug Discov
|
2003
|
1.22
|
22
|
Erlotinib hydrochloride.
|
Nat Rev Drug Discov
|
2005
|
1.22
|
23
|
Asenapine.
|
Nat Rev Drug Discov
|
2009
|
1.21
|
24
|
Ipilimumab.
|
Nat Rev Drug Discov
|
2011
|
1.20
|
25
|
Duloxetine hydrochloride.
|
Nat Rev Drug Discov
|
2004
|
1.17
|
26
|
Vismodegib.
|
Nat Rev Drug Discov
|
2012
|
1.16
|
27
|
Oxaliplatin.
|
Nat Rev Drug Discov
|
2004
|
1.14
|
28
|
Eribulin mesylate.
|
Nat Rev Drug Discov
|
2011
|
1.14
|
29
|
Tolvaptan.
|
Nat Rev Drug Discov
|
2009
|
1.13
|
30
|
Ivacaftor.
|
Nat Rev Drug Discov
|
2012
|
1.12
|
31
|
Febuxostat.
|
Nat Rev Drug Discov
|
2009
|
1.12
|
32
|
Golimumab.
|
Nat Rev Drug Discov
|
2009
|
1.11
|
33
|
Lapatinib.
|
Nat Rev Drug Discov
|
2007
|
1.10
|
34
|
Bevacizumab.
|
Nat Rev Drug Discov
|
2004
|
1.09
|
35
|
Lacosamide.
|
Nat Rev Drug Discov
|
2008
|
1.09
|
36
|
Ranibizumab.
|
Nat Rev Drug Discov
|
2006
|
1.08
|
37
|
Sunitinib maleate.
|
Nat Rev Drug Discov
|
2006
|
1.07
|
38
|
Crizotinib.
|
Nat Rev Drug Discov
|
2011
|
1.05
|
39
|
Plerixafor.
|
Nat Rev Drug Discov
|
2009
|
1.04
|
40
|
Brentuximab vedotin.
|
Nat Rev Drug Discov
|
2012
|
1.04
|
41
|
Aflibercept.
|
Nat Rev Drug Discov
|
2012
|
1.04
|
42
|
Exenatide.
|
Nat Rev Drug Discov
|
2005
|
1.02
|
43
|
Pazopanib.
|
Nat Rev Drug Discov
|
2010
|
1.02
|
44
|
Ustekinumab.
|
Nat Rev Drug Discov
|
2009
|
1.02
|
45
|
Decitabine.
|
Nat Rev Drug Discov
|
2006
|
1.02
|
46
|
Varenicline.
|
Nat Rev Drug Discov
|
2006
|
0.99
|
47
|
Gefitinib.
|
Nat Rev Drug Discov
|
2003
|
0.99
|
48
|
Certolizumab pegol.
|
Nat Rev Drug Discov
|
2008
|
0.98
|
49
|
Pregabalin.
|
Nat Rev Drug Discov
|
2005
|
0.98
|
50
|
Teriparatide.
|
Nat Rev Drug Discov
|
2003
|
0.98
|
51
|
Belatacept.
|
Nat Rev Drug Discov
|
2011
|
0.96
|
52
|
Ruxolitinib.
|
Nat Rev Drug Discov
|
2012
|
0.96
|
53
|
Telavancin.
|
Nat Rev Drug Discov
|
2009
|
0.94
|
54
|
Dronedarone.
|
Nat Rev Drug Discov
|
2009
|
0.93
|
55
|
Ezogabine (retigabine).
|
Nat Rev Drug Discov
|
2011
|
0.92
|
56
|
Ecallantide.
|
Nat Rev Drug Discov
|
2010
|
0.91
|
57
|
Posaconazole.
|
Nat Rev Drug Discov
|
2007
|
0.91
|
58
|
Tigecycline.
|
Nat Rev Drug Discov
|
2005
|
0.91
|
59
|
Tafamidis.
|
Nat Rev Drug Discov
|
2012
|
0.91
|
60
|
Surgery for brain edema.
|
Neurosurg Focus
|
2007
|
0.91
|
61
|
Pegaptanib sodium.
|
Nat Rev Drug Discov
|
2005
|
0.90
|
62
|
Prasugrel.
|
Nat Rev Drug Discov
|
2009
|
0.90
|
63
|
Memantine hydrochloride.
|
Nat Rev Drug Discov
|
2004
|
0.88
|
64
|
Fresh from the pipeline. Ticagrelor.
|
Nat Rev Drug Discov
|
2011
|
0.87
|
65
|
Telbivudine.
|
Nat Rev Drug Discov
|
2007
|
0.87
|
66
|
Alvimopan.
|
Nat Rev Drug Discov
|
2008
|
0.86
|
67
|
Romiplostim.
|
Nat Rev Drug Discov
|
2008
|
0.86
|
68
|
Sitagliptin.
|
Nat Rev Drug Discov
|
2007
|
0.86
|
69
|
Quadrivalent human papillomavirus recombinant vaccine.
|
Nat Rev Drug Discov
|
2006
|
0.85
|
70
|
Velaglucerase alfa.
|
Nat Rev Drug Discov
|
2010
|
0.85
|
71
|
Tipranavir.
|
Nat Rev Drug Discov
|
2005
|
0.85
|
72
|
Specificity concerns with antibodies for receptor mapping.
|
Nat Rev Drug Discov
|
2009
|
0.85
|
73
|
Roflumilast.
|
Nat Rev Drug Discov
|
2010
|
0.85
|
74
|
Aripiprazole.
|
Nat Rev Drug Discov
|
2003
|
0.84
|
75
|
Belimumab.
|
Nat Rev Drug Discov
|
2011
|
0.83
|
76
|
Pemetrexed disodium.
|
Nat Rev Drug Discov
|
2004
|
0.83
|
77
|
Differential cyclin E expression in human in-stent stenosis smooth muscle cells identifies targets for selective anti-restenosis therapy.
|
Cardiovasc Res
|
2003
|
0.83
|
78
|
Pirfenidone.
|
Nat Rev Drug Discov
|
2011
|
0.83
|
79
|
Pasireotide.
|
Nat Rev Drug Discov
|
2012
|
0.81
|
80
|
Inhaled aztreonam.
|
Nat Rev Drug Discov
|
2010
|
0.81
|
81
|
Ofatumumab.
|
Nat Rev Drug Discov
|
2010
|
0.81
|
82
|
Entecavir.
|
Nat Rev Drug Discov
|
2005
|
0.81
|
83
|
Ranolazine.
|
Nat Rev Drug Discov
|
2006
|
0.81
|
84
|
Efalizumab.
|
Nat Rev Drug Discov
|
2004
|
0.81
|
85
|
Meningococcal group A, C, Y and W-135 conjugate vaccine.
|
Nat Rev Drug Discov
|
2010
|
0.80
|
86
|
Eplerenone.
|
Nat Rev Drug Discov
|
2003
|
0.80
|
87
|
Natalizumab.
|
Nat Rev Drug Discov
|
2005
|
0.80
|
88
|
Abiraterone acetate.
|
Nat Rev Drug Discov
|
2011
|
0.80
|
89
|
Fresh from the pipeline: Ramelteon.
|
Nat Rev Drug Discov
|
2005
|
0.79
|
90
|
Bendamustine.
|
Nat Rev Drug Discov
|
2008
|
0.79
|
91
|
Rasagiline.
|
Nat Rev Drug Discov
|
2005
|
0.78
|
92
|
Omalizumab.
|
Nat Rev Drug Discov
|
2004
|
0.78
|
93
|
Clofarabine.
|
Nat Rev Drug Discov
|
2005
|
0.78
|
94
|
Galsulfase.
|
Nat Rev Drug Discov
|
2006
|
0.78
|
95
|
Lisdexamfetamine dimesylate.
|
Nat Rev Drug Discov
|
2007
|
0.78
|
96
|
Telithromycin.
|
Nat Rev Drug Discov
|
2004
|
0.77
|
97
|
Tiotropium bromide.
|
Nat Rev Drug Discov
|
2004
|
0.77
|
98
|
Atazanavir sulphate.
|
Nat Rev Drug Discov
|
2003
|
0.77
|
99
|
Vernakalant.
|
Nat Rev Drug Discov
|
2010
|
0.77
|
100
|
Atomoxetine hydrochloride.
|
Nat Rev Drug Discov
|
2004
|
0.77
|
101
|
Nelarabine.
|
Nat Rev Drug Discov
|
2006
|
0.77
|
102
|
Inhaled human insulin.
|
Nat Rev Drug Discov
|
2006
|
0.76
|
103
|
Tesamorelin.
|
Nat Rev Drug Discov
|
2011
|
0.75
|
104
|
Antiparasitic drugs: Two-pronged tactics for malaria control.
|
Nat Rev Drug Discov
|
2012
|
0.75
|
105
|
Medicinal chemistry: Shades of chemical beauty.
|
Nat Rev Drug Discov
|
2012
|
0.75
|
106
|
Drotrecogin alpha (activated).
|
Nat Rev Drug Discov
|
2003
|
0.75
|
107
|
Fresh from the pipeline. Ezetimibe.
|
Nat Rev Drug Discov
|
2003
|
0.75
|
108
|
Ambrisentan.
|
Nat Rev Drug Discov
|
2007
|
0.75
|
109
|
Tadalafil and vardenafil.
|
Nat Rev Drug Discov
|
2004
|
0.75
|
110
|
Sinus pericranii--"Don't judge a lump by its surface".
|
J Craniofac Surg
|
2010
|
0.75
|
111
|
Rosuvastatin calcium.
|
Nat Rev Drug Discov
|
2003
|
0.75
|