1
|
Efficacy and safety of recombinant human activated protein C for severe sepsis.
|
N Engl J Med
|
2001
|
27.70
|
2
|
Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group.
|
N Engl J Med
|
1991
|
9.99
|
3
|
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group.
|
Crit Care Med
|
1997
|
4.86
|
4
|
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.
|
N Engl J Med
|
1987
|
3.89
|
5
|
Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature.
|
Crit Care Med
|
1995
|
3.74
|
6
|
Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.
|
Crit Care Med
|
1989
|
3.41
|
7
|
Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli.
|
J Cell Sci
|
1992
|
3.18
|
8
|
Hypothermia in the sepsis syndrome and clinical outcome. The Methylprednisolone Severe Sepsis Study Group.
|
Crit Care Med
|
1992
|
2.99
|
9
|
Immunohistochemical detection of p53 protein in mammary carcinoma: an important new independent indicator of prognosis?
|
Hum Pathol
|
1993
|
2.27
|
10
|
Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation.
|
Crit Care Med
|
2000
|
1.70
|
11
|
New variant Creutzfeldt-Jakob disease: psychiatric features.
|
Lancet
|
1997
|
1.55
|
12
|
Early methylprednisolone treatment for septic syndrome and the adult respiratory distress syndrome.
|
Chest
|
1987
|
1.43
|
13
|
Severe recalcitrant erythematous desquamating disorder associated with fatal recurrent toxic shock syndrome in a patient without AIDS.
|
Clin Infect Dis
|
1997
|
1.40
|
14
|
p53 represses androgen-induced transactivation of prostate-specific antigen by disrupting hAR amino- to carboxyl-terminal interaction.
|
J Biol Chem
|
2001
|
1.30
|
15
|
The Rapid Acute Physiology Score.
|
Am J Emerg Med
|
1987
|
1.24
|
16
|
The clinical evaluation of new drugs for sepsis. A prospective study design based on survival analysis.
|
JAMA
|
1993
|
1.14
|
17
|
Regulation of human alveolar macrophage inflammatory cytokine production by interleukin-10.
|
Clin Immunol Immunopathol
|
1996
|
1.10
|
18
|
c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation.
|
Oncogene
|
2006
|
1.09
|
19
|
Relative concentrations of endotoxin-binding proteins in body fluids during infection.
|
Lancet
|
1994
|
1.05
|
20
|
Comparison between p53 staining in tissue sections and p53 proteins levels measured by an ELISA technique.
|
Br J Cancer
|
1993
|
1.04
|
21
|
Use of predicted risk of mortality to evaluate the efficacy of anticytokine therapy in sepsis. The rhIL-1ra Phase III Sepsis Syndrome Study Group.
|
Crit Care Med
|
1996
|
1.02
|
22
|
The clinical spectrum of toxic shock syndrome.
|
West J Med
|
1981
|
0.98
|
23
|
Interleukin 10 (IL-10)-mediated inhibition of inflammatory cytokine production by human alveolar macrophages.
|
Cytokine
|
2000
|
0.97
|
24
|
Fibrous dysplasia of the axis. A case report.
|
Spine (Phila Pa 1976)
|
1989
|
0.91
|
25
|
Intrathecal sodium diatrizoate. Report of a case complicated by acute renal failure and review of the literature.
|
Neurology
|
1966
|
0.88
|
26
|
c-Jun potentiates the functional interaction between the amino and carboxyl termini of the androgen receptor.
|
J Biol Chem
|
2001
|
0.87
|
27
|
Enzymic differentiation in cultured foetal hepatocytes of the rat. Induction of serine dehydratase activity by dexamethasone and dibutyryl cyclic AMP.
|
Differentiation
|
1983
|
0.85
|
28
|
Parallel changes in vivo in microsomal inorganic pyrophosphatase, pyrophosphate-glucose phosphotransferase and glucose 6-phosphatase activities.
|
Biochim Biophys Acta
|
1966
|
0.84
|
29
|
Detrimental effects of high-dose methylprednisolone sodium succinate on serum concentrations of hepatic and renal function indicators in severe sepsis and septic shock. The Methylprednisolone Severe Sepsis Study Group.
|
Crit Care Med
|
1993
|
0.84
|
30
|
Deterioration of conjunctival PO2 after CPR.
|
Ann Emerg Med
|
1987
|
0.83
|
31
|
Effects of hyperventilation on conjunctival oxygen tension in humans.
|
Crit Care Med
|
1986
|
0.83
|
32
|
Specific cloning of DNA fragments unique to the dog Y chromosome.
|
Genet Anal Tech Appl
|
1994
|
0.82
|
33
|
Effect of nitroprusside on pulmonary hypertension and lung fluid balance after E. coli endotoxin.
|
Crit Care Med
|
1982
|
0.81
|
34
|
c-Jun targets amino terminus of androgen receptor in regulating androgen-responsive transcription.
|
Endocrine
|
2000
|
0.80
|
35
|
A prolonged severe intoxication after ingestion of phenytoin and phenobarbital.
|
West J Med
|
1981
|
0.78
|
36
|
Emergency medicine: the use of activated charcoal in cases of poisoning and drug overdose.
|
West J Med
|
1985
|
0.78
|
37
|
Cardiorespiratory failure in toxic shock syndrome: effect of dobutamine.
|
Crit Care Med
|
1985
|
0.78
|
38
|
Cyanide poisoning after bitter almond ingestion.
|
West J Med
|
1982
|
0.77
|
39
|
Prolonged bromide intoxication resulting from a gastric bezoar.
|
Arch Intern Med
|
1984
|
0.77
|
40
|
Transformation-induced alterations in the regulation of tyrosine aminotransferase expression in fetal rat hepatocytes: changes in hormone inducibility and the DNase-hypersensitive site.
|
Cancer Res
|
1993
|
0.76
|
41
|
Internal medicine-important advances in clinical medicine: toxic shock syndrome.
|
West J Med
|
1983
|
0.75
|
42
|
An evaluation of the hemodynamic effects of HA-1A human monoclonal antibody.
|
Crit Care Med
|
1994
|
0.75
|
43
|
Activated protein C differs from protein C pharmacokinetically and pharmacodynamically.
|
Shock
|
1999
|
0.75
|
44
|
Altered keratin biosynthesis follows inhibition of scale morphogenesis by hydrocortisone.
|
Dev Biol
|
1984
|
0.75
|
45
|
Trazodone-induced transient hypomanic symptoms and their management.
|
Br J Psychiatry
|
1991
|
0.75
|
46
|
Critical care medicine: an annotated bibliography of the recent literature.
|
Am J Emerg Med
|
1986
|
0.75
|
47
|
Selective left endobronchial suctioning in the intubated patient.
|
Chest
|
1989
|
0.75
|
48
|
A unique academic approach to critical care-emergency medicine training.
|
JACEP
|
1976
|
0.75
|
49
|
Mobile triage team in a community disaster plan.
|
JACEP
|
1977
|
0.75
|
50
|
Protein nutrition and the biochemical composition of the uterus.
|
Fertil Steril
|
1968
|
0.75
|
51
|
Effect of lobar acid injury on pulmonary perfusion and gas exchange in dogs.
|
J Appl Physiol Respir Environ Exerc Physiol
|
1980
|
0.75
|
52
|
Physiology of respiration.
|
Emerg Med Clin North Am
|
1983
|
0.75
|
53
|
Infantile botulism.
|
JACEP
|
1977
|
0.75
|
54
|
Effect of nitroprusside administration and sudden withdrawal on pulmonary vascular tone and lung fluid balance.
|
Crit Care Med
|
1984
|
0.75
|
55
|
Salicylate-induced pulmonary edema: clinical characteristics in children.
|
Am J Emerg Med
|
1985
|
0.75
|
56
|
Microprocessor-based multi-patient environmental-control system for a spinal injuries unit.
|
Med Biol Eng Comput
|
1980
|
0.75
|
57
|
Accidental mediastinal entry via left internal jugular vein cannulation.
|
Intensive Care Med
|
1985
|
0.75
|
58
|
A comparison of hydrocortisone and triamcinolone inhibition of scale and feather development.
|
Teratology
|
1986
|
0.75
|
59
|
Prediction of changing cerebral blood flow by use of the conjunctival oxygen tension/arterial oxygen tension index.
|
Crit Care Med
|
1989
|
0.75
|
60
|
The effect of triamcinolone on the development of the bursa of Fabricius in chick embryos.
|
Teratology
|
1980
|
0.75
|
61
|
Influence of alterations in foregoing life-sustaining treatment practices on a clinical sepsis trial. The HA-1A Sepsis Study Group.
|
Crit Care Med
|
1997
|
0.75
|
62
|
Critical care medicine: an annotated bibliography of the recent literature.
|
Am J Emerg Med
|
1985
|
0.75
|