TPO/Mpl Studies in Agnogenic Myeloid Metaplasia.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 15691382)

Published in Cell Commun Signal on February 03, 2005

Authors

Kirugaval C Hemavathy1, Kathir Suppiah, Gazala Hashmi, Allan D Novetsky, Jen C Wang

Author Affiliations

1: Division of Hematology/Oncology, Department of Medicine, Maimonides Medical Center, Brooklyn, New York, USA. jcwang5@aol.com.

Articles cited by this

Thrombocytopenia in c-mpl-deficient mice. Science (1994) 2.64

eIF4E expression in tumors: its possible role in progression of malignancies. Int J Biochem Cell Biol (1999) 2.57

Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera. N Engl J Med (1998) 2.29

Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Blood (2004) 2.27

Mpl Baltimore: a thrombopoietin receptor polymorphism associated with thrombocytosis. Proc Natl Acad Sci U S A (2004) 1.72

Increased intraplatelet levels of platelet-derived growth factor and transforming growth factor-beta in patients with myelofibrosis with myeloid metaplasia. Br J Haematol (1991) 1.62

Elevated levels of basic fibroblast growth factor in megakaryocytes and platelets from patients with idiopathic myelofibrosis. Br J Haematol (1997) 1.55

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood (1993) 1.42

Elevated thrombopoietin levels in patients with myelofibrosis may not be due to enhanced production of thrombopoietin by bone marrow. Leuk Res (2003) 1.42

A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation. Blood (1996) 1.40

Thrombopoietin. N Engl J Med (1998) 1.32

Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood (1995) 1.28

Familial essential thrombocythemia associated with one-base deletion in the 5'-untranslated region of the thrombopoietin gene. Blood (1998) 1.23

Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene. Br J Haematol (1999) 1.19

Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways. J Biol Chem (2001) 1.10

Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia. Blood (1997) 1.09

Structure and transcription of the human c-mpl gene (MPL). Genomics (1994) 1.08

Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera. Blood (1999) 1.05

Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L. Blood (1999) 1.01

The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells. Blood (2000) 0.99

Human platelets as a model for the binding and degradation of thrombopoietin. Blood (1997) 0.95

Serum thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis. Thromb Haemost (1997) 0.94

Transforming growth factor-beta1 (TGF-beta1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with high specificity. Blood (1999) 0.92

Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia. Blood (1996) 0.92

Pharmacokinetic model of target-mediated disposition of thrombopoietin. AAPS PharmSci (2004) 0.89

Ectopic expression of murine TPO receptor (c-mpl) in mice is pathogenic and induces erythroblastic proliferation. Blood (1996) 0.87

Simultaneous measurement of serum thrombopoietin and expression of megakaryocyte c-Mpl with clinical and laboratory correlates for myelofibrosis with myeloid metaplasia. Eur J Haematol (2002) 0.86

Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders. Br J Haematol (1996) 0.86

Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment. Blood (1997) 0.83

Platelet c-mpl expression is dysregulated in patients with essential thrombocythaemia but this is not of diagnostic value. Br J Haematol (1999) 0.83

High-level expression of Mpl in platelets and megakaryocytes is independent of thrombopoietin. Blood (1999) 0.81

A novel thrombopoietin signaling defect in polycythemia vera platelets. Stem Cells (1998) 0.80

Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia. Leukemia (1997) 0.80

Articles by these authors

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet (2006) 13.16

Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet (2006) 7.90

Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry (2008) 6.73

A genome-wide association study of alcohol dependence. Proc Natl Acad Sci U S A (2010) 4.94

Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet (2009) 2.86

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res (2009) 2.63

Nicotinic receptor gene variants influence susceptibility to heavy smoking. Cancer Epidemiol Biomarkers Prev (2008) 2.58

The strength of selection on ultraconserved elements in the human genome. Am J Hum Genet (2007) 2.21

Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. Am J Psychiatry (2012) 2.02

A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biol Psychiatry (2008) 1.88

Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition. Int J Psychophysiol (2004) 1.79

Using dimensional models of externalizing psychopathology to aid in gene identification. Arch Gen Psychiatry (2008) 1.73

Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples. Am J Hum Genet (2007) 1.73

Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. AAPS J (2009) 1.68

H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addict Biol (2010) 1.64

Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am J Hum Genet (2005) 1.49

Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. Alcohol Clin Exp Res (2007) 1.47

Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. Addiction (2007) 1.40

Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol (2012) 1.34

Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. Behav Genet (2005) 1.32

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenet Genomics (2011) 1.30

Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Drug Alcohol Depend (2007) 1.23

Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet (2009) 1.12

Dissection of the phenotypic and genotypic associations with nicotinic dependence. Nicotine Tob Res (2011) 1.09

A cholinergic receptor gene (CHRM2) affects event-related oscillations. Behav Genet (2006) 1.09

Quantitative analysis of growth factor production in the mechanism of fibrosis in agnogenic myeloid metaplasia. Exp Hematol (2006) 1.07

Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence. Addiction (2009) 1.04

An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. Arch Gen Psychiatry (2008) 1.02

Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. Behav Genet (2006) 0.99

A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9. Biol Psychiatry (2007) 0.95

Hypermethylation of the P15INK4b and P16INK4a in agnogenic myeloid metaplasia (AMM) and AMM in leukaemic transformation. Br J Haematol (2002) 0.94

Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. Am J Med Genet B Neuropsychiatr Genet (2009) 0.92

Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample. Behav Genet (2005) 0.92

Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes. Drug Alcohol Depend (2012) 0.88

Variants weakly correlated with CHRNA5 D398N polymorphism should be considered in transcriptional deregulation at the 15q25 locus associated with lung cancer risk. Clin Cancer Res (2009) 0.86

Common polymorphisms in FMO1 are associated with nicotine dependence. Pharmacogenet Genomics (2011) 0.84

Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. Am J Med Genet B Neuropsychiatr Genet (2004) 0.82

Subcutaneous panniculitis-like T-cell lymphoma in a patient with long-term remission with standard chemotherapy. J Natl Med Assoc (2007) 0.80

Osteosclerosis in idiopathic myelofibrosis is related to the overproduction of osteoprotegerin (OPG). Exp Hematol (2004) 0.80

Plasma matrix metalloproteinase and tissue inhibitor of metalloproteinase in patients with agnogenic myeloid metaplasia or idiopathic primary myelofibrosis. Br J Haematol (2002) 0.80

Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Hum Genet (2010) 0.80

Epigenetic modifications: new therapeutic targets in primary myelofibrosis. Curr Stem Cell Res Ther (2009) 0.79

Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation. Leuk Res (2005) 0.77

Response of hemorrhagic bullous skin lesions of the breast secondary to primary systemic amyloidosis to a five-drug combination chemotherapy: a case report and review of the literature. Exp Hematol Oncol (2012) 0.77

Prostate carcinoma, presenting with a solitary osteolytic bone lesion to the right hip. Radiol Case Rep (2015) 0.75

Thrombotic thrombocytopenic purpura in a patient with interferon treated hepatitis C successfully treated with rituximab. Hematol Rep (2013) 0.75

Apparent beneficial effects by nab-paclitaxel in the treatment of refractory metastatic ovarian carcinoma. Anticancer Drugs (2009) 0.75