Kevin R Coombes

Author PubWeight™ 126.85‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments. Bioinformatics 2004 4.58
2 Feature extraction and quantification for mass spectrometry in biomedical applications using the mean spectrum. Bioinformatics 2005 4.26
3 An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res 2012 3.48
4 Signal in noise: evaluating reported reproducibility of serum proteomic tests for ovarian cancer. J Natl Cancer Inst 2005 3.31
5 Non-parametric quantification of protein lysate arrays. Bioinformatics 2007 3.18
6 Functional proteomic profiling of AML predicts response and survival. Blood 2008 2.90
7 Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J Natl Cancer Inst 2012 2.79
8 Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins. Clin Cancer Res 2005 2.76
9 Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov 2012 2.68
10 Microarrays: retracing steps. Nat Med 2007 2.39
11 microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood 2010 2.25
12 The importance of experimental design in proteomic mass spectrometry experiments: some cautionary tales. Brief Funct Genomic Proteomic 2005 2.08
13 Applications of beta-mixture models in bioinformatics. Bioinformatics 2005 2.04
14 Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression. J Biol Chem 2006 2.01
15 Bayesian analysis of mass spectrometry proteomic data using wavelet-based functional mixed models. Biometrics 2007 2.01
16 A comprehensive approach to the analysis of matrix-assisted laser desorption/ionization-time of flight proteomics spectra from serum samples. Proteomics 2003 2.01
17 The bimodality index: a criterion for discovering and ranking bimodal signatures from cancer gene expression profiling data. Cancer Inform 2009 1.98
18 Run batch effects potentially compromise the usefulness of genomic signatures for ovarian cancer. J Clin Oncol 2008 1.96
19 Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol Cancer Ther 2008 1.92
20 Obtaining reliable information from minute amounts of RNA using cDNA microarrays. BMC Genomics 2002 1.75
21 Variable slope normalization of reverse phase protein arrays. Bioinformatics 2009 1.66
22 Robust gene expression signature from formalin-fixed paraffin-embedded samples predicts prognosis of non-small-cell lung cancer patients. Clin Cancer Res 2011 1.59
23 Enrichment analysis in high-throughput genomics - accounting for dependency in the NULL. Brief Bioinform 2006 1.52
24 Prognostic impact and targeting of CRM1 in acute myeloid leukemia. Blood 2013 1.52
25 Analysis of mass spectrometry profiles of the serum proteome. Clin Chem 2005 1.46
26 Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens. Blood 2008 1.46
27 Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery. J Proteome Res 2005 1.45
28 Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia. Blood 2010 1.43
29 Validation of oligonucleotide microarray data using microfluidic low-density arrays: a new statistical method to normalize real-time RT-PCR data. Biotechniques 2005 1.39
30 miRNA expression profiles in head and neck squamous cell carcinoma and adjacent normal tissue. Head Neck 2009 1.38
31 Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-beta pathway signaling indicates response to primary chemotherapy. Clin Cancer Res 2010 1.38
32 Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia. Blood 2011 1.34
33 Prognostic biomarkers for esophageal adenocarcinoma identified by analysis of tumor transcriptome. PLoS One 2010 1.33
34 Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer. Clin Proteomics 2011 1.32
35 Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia. Clin Cancer Res 2010 1.30
36 Gene expression profile of metastatic human pancreatic cancer cells depends on the organ microenvironment. Cancer Res 2007 1.29
37 Bayesian shrinkage estimation of the relative abundance of mRNA transcripts using SAGE. Biometrics 2003 1.28
38 High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia. Blood 2003 1.28
39 Clinical evaluation of chemotherapy response predictors developed from breast cancer cell lines. Breast Cancer Res Treat 2009 1.25
40 Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest 2010 1.25
41 Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML. Blood 2012 1.25
42 Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. PLoS One 2012 1.24
43 Stem cell-ness: a "magic marker" for cancer. J Clin Invest 2005 1.20
44 Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry. Breast Cancer Res Treat 2005 1.20
45 What information should be required to support clinical "omics" publications? Clin Chem 2011 1.19
46 Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation. Eur J Cancer 2011 1.16
47 Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML. Blood 2010 1.15
48 PrepMS: TOF MS data graphical preprocessing tool. Bioinformatics 2006 1.13
49 Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene. Leuk Res 2008 1.11
50 Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence. J Thorac Oncol 2010 1.08
51 Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer. J Natl Cancer Inst 2014 1.04
52 Zonal heterogeneity for gene expression in human pancreatic carcinoma. Cancer Res 2007 1.03
53 Relax with CouchDB--into the non-relational DBMS era of bioinformatics. Genomics 2012 1.02
54 Proteomic profiling identifies distinct protein patterns in acute myelogenous leukemia CD34+CD38- stem-like cells. PLoS One 2013 1.01
55 SIBER: systematic identification of bimodally expressed genes using RNAseq data. Bioinformatics 2013 1.00
56 Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia. Cancer Res 2010 0.99
57 Merging microarray data, robust feature selection, and predicting prognosis in prostate cancer. Cancer Inform 2007 0.99
58 Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents. J Natl Cancer Inst 2014 0.99
59 Use of reverse phase protein microarrays to study protein expression in leukemia: technical and methodological lessons learned. Methods Mol Biol 2011 0.96
60 Analysis of dose-response effects on gene expression data with comparison of two microarray platforms. Bioinformatics 2005 0.95
61 Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells. Ann Hematol 2012 0.94
62 Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer. Int J Oncol 2005 0.94
63 Independent validation of a model using cell line chemosensitivity to predict response to therapy. J Natl Cancer Inst 2013 0.92
64 Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead. Adv Exp Med Biol 2008 0.92
65 Identification and validation of biomarkers of IgV(H) mutation status in chronic lymphocytic leukemia using microfluidics quantitative real-time polymerase chain reaction technology. J Mol Diagn 2007 0.92
66 Characterizing the molecular spatial and temporal field of injury in early-stage smoker non-small cell lung cancer patients after definitive surgery by expression profiling. Cancer Prev Res (Phila) 2012 0.92
67 Immunohistochemical detection of ZAP70 in chronic lymphocytic leukemia predicts immunoglobulin heavy chain gene mutation status and time to progression. Mod Pathol 2010 0.90
68 Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer. Gynecol Oncol 2012 0.89
69 Bias, randomization, and ovarian proteomic data: a reply to "producers and consumers". Cancer Inform 2005 0.89
70 Inter-gene correlation on oligonucleotide arrays: how much does normalization matter? Am J Pharmacogenomics 2005 0.88
71 Reproducibility of SELDI Spectra Across Time and Laboratories. Cancer Inform 2011 0.87
72 Response to Preprocessing of oligonucleotide array data. Nat Biotechnol 2004 0.86
73 Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition. BMC Genomics 2014 0.85
74 Sources of variation in false discovery rate estimation include sample size, correlation, and inherent differences between groups. BMC Bioinformatics 2012 0.85
75 Gene sequence signatures revealed by mining the UniGene affiliation network. Bioinformatics 2005 0.85
76 Proteomic biomarkers apolipoprotein A1, truncated transthyretin and connective tissue activating protein III enhance the sensitivity of CA125 for detecting early stage epithelial ovarian cancer. Gynecol Oncol 2011 0.85
77 Individualized molecular medicine: linking functional proteomics to select therapeutics targeting the PI3K pathway for specific patients. Adv Exp Med Biol 2008 0.85
78 LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patients. Blood 2011 0.83
79 A comprehensive assessment of p53-responsive genes following adenoviral-p53 gene transfer in Bcl-2-expressing prostate cancer cells. Oncogene 2004 0.83
80 Biological validation of differentially expressed genes in chronic lymphocytic leukemia identified by applying multiple statistical methods to oligonucleotide microarrays. J Mol Diagn 2005 0.82
81 Tissue-specific function of lymph node fibroblastic reticulum cells. Pathobiology 2006 0.82
82 targetHub: a programmable interface for miRNA-gene interactions. Bioinformatics 2013 0.81
83 integIRTy: a method to identify genes altered in cancer by accounting for multiple mechanisms of regulation using item response theory. Bioinformatics 2012 0.80
84 Genomic variation by whole-genome SNP mapping arrays predicts time-to-event outcome in patients with chronic lymphocytic leukemia: a comparison of CLL and HapMap genotypes. J Mol Diagn 2012 0.80
85 Establishment and characterization by gene expression profiling of a new diffuse large B-cell lymphoma cell line, EJ-1, carrying t(14;18) and t(8;14) translocations. Lab Invest 2003 0.79
86 A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia. PLoS One 2011 0.79
87 Latent Feature Decompositions for Integrative Analysis of Multi-Platform Genomic Data. IEEE/ACM Trans Comput Biol Bioinform 2014 0.78
88 Association between ductal fluid proteomic expression profiles and the presence of lymph node metastases in women with breast cancer. Surgery 2004 0.77
89 Statistical contributions to proteomic research. Methods Mol Biol 2010 0.77
90 Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia. Respir Res 2010 0.77
91 Blasted cell line names. Cancer Inform 2010 0.75