PubRank

Ken J Ishii

Author PubWeight™ 165.55‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006 22.65
2 IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005 18.32
3 Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 2004 5.71
4 Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol 2008 5.10
5 Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med 2006 5.01
6 Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol 2006 4.15
7 Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol 2006 4.01
8 The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci U S A 2007 3.93
9 Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med 2005 3.85
10 Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. J Immunol 2007 3.14
11 A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med 2009 2.92
12 Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med 2005 2.90
13 Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nat Rev Immunol 2012 2.48
14 DNA released from dying host cells mediates aluminum adjuvant activity. Nat Med 2011 2.41
15 Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. Cell Host Microbe 2010 2.03
16 Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses. J Immunol 2008 1.86
17 Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J Immunol 2003 1.84
18 Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice. Proc Natl Acad Sci U S A 2012 1.74
19 Pathological role of Toll-like receptor signaling in cerebral malaria. Int Immunol 2006 1.66
20 Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms. Immunity 2011 1.65
21 Innate immune response to viral infection. Cytokine 2008 1.63
22 Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling. J Immunol 2006 1.60
23 Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide. J Leukoc Biol 2002 1.48
24 Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes. Sci Transl Med 2010 1.46
25 Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon. J Control Release 2012 1.46
26 Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells. J Immunol 2004 1.45
27 Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9. Semin Immunol 2004 1.44
28 DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Natl Acad Sci U S A 2013 1.41
29 Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice. Arthritis Rheum 2005 1.40
30 Transcriptional regulation of the human TLR9 gene. J Immunol 2004 1.38
31 TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. Eur J Immunol 2005 1.36
32 A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity. J Immunol 2011 1.30
33 NLRP4 negatively regulates autophagic processes through an association with beclin1. J Immunol 2011 1.29
34 Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J Immunol 2008 1.23
35 A critical role of IL-33 in experimental allergic rhinitis. J Allergy Clin Immunol 2012 1.18
36 Effect of suppressive DNA on CpG-induced immune activation. J Immunol 2002 1.16
37 Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J Exp Med 2007 1.16
38 Innate and adaptive immune responses to viral infection and vaccination. Curr Opin Virol 2011 1.15
39 Manipulation of host innate immune responses by the malaria parasite. Trends Microbiol 2007 1.14
40 Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine. Infect Immun 2002 1.13
41 Novel strategies to improve DNA vaccine immunogenicity. Curr Gene Ther 2011 1.12
42 Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9. J Immunol 2005 1.11
43 Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides. Arthritis Rheum 2002 1.08
44 CpG oligodeoxynucleotides enhance neonatal resistance to Listeria infection. J Immunol 2005 1.08
45 Suppressive oligonucleotides protect against collagen-induced arthritis in mice. Arthritis Rheum 2004 1.06
46 Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner. J Virol 2009 1.05
47 Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome. Eur J Immunol 2010 1.04
48 CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes. J Immunol 2005 1.03
49 Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination. Front Cell Infect Microbiol 2013 1.01
50 Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis. Arthritis Rheum 2003 1.00
51 Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36. Parasitol Int 2010 0.98
52 Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc Natl Acad Sci U S A 2014 0.98
53 Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity. J Virol 2006 0.97
54 Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine. J Immunol 2007 0.96
55 Induction of type I interferon by adenovirus-encoded small RNAs. Proc Natl Acad Sci U S A 2010 0.95
56 Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects. Int Rev Immunol 2013 0.94
57 Serologic markers in relation to parasite exposure history help to estimate transmission dynamics of Plasmodium vivax. PLoS One 2011 0.93
58 The malarial metabolite hemozoin and its potential use as a vaccine adjuvant. Allergol Int 2010 0.92
59 Effect of CpG oligodeoxynucleotides on the immunogenicity of Pfs25, a Plasmodium falciparum transmission-blocking vaccine antigen. Infect Immun 2004 0.92
60 Intracellular DNA sensors in immunity. Curr Opin Immunol 2008 0.92
61 Fragments of genomic DNA released by injured cells activate innate immunity and suppress endocrine function in the thyroid. Endocrinology 2011 0.92
62 CpG DNA: recognition by and activation of monocytes. Microbes Infect 2002 0.92
63 Extrachromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA. J Virol 2009 0.91
64 Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism. Cell Host Microbe 2012 0.89
65 Suppressive oligodeoxynucleotides inhibit CpG-induced inflammation of the mouse lung. Crit Care Med 2004 0.89
66 Intranasal immunization with a mixture of PspA and a Toll-like receptor agonist induces specific antibodies and enhances bacterial clearance in the airways of mice. Vaccine 2009 0.89
67 CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection. Infect Immun 2004 0.88
68 Molecular and cellular mechanisms of DNA vaccines. Hum Vaccin 2008 0.88
69 Plasmodium falciparum serine repeat antigen 5 (SE36) as a malaria vaccine candidate. Vaccine 2011 0.88
70 Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36. PLoS One 2013 0.85
71 TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur J Immunol 2015 0.85
72 Contribution of interferon-beta to the immune activation induced by double-stranded DNA. Immunology 2006 0.85
73 Adjuvants in influenza vaccines. Vaccine 2012 0.85
74 Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors. J Leukoc Biol 2005 0.84
75 Role of Extrachromosomal Histone H2B on Recognition of DNA Viruses and Cell Damage. Front Genet 2013 0.83
76 Intranasal vaccination with pneumococcal surface protein A plus poly(I:C) protects against secondary pneumococcal pneumonia in mice. Vaccine 2011 0.83
77 Innate immune control of nucleic acid-based vaccine immunogenicity. Expert Rev Vaccines 2009 0.83
78 Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells. J Virol 2013 0.81
79 A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells. Bioconjug Chem 2007 0.81
80 Immune interventions of human diseases through toll-like receptors. Adv Exp Med Biol 2009 0.81
81 The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant. PLoS One 2013 0.80
82 A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant. J Immunol 2009 0.80
83 Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia. J Neurochem 2013 0.79
84 TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine. Expert Rev Vaccines 2010 0.79
85 TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models. Hum Vaccin Immunother 2013 0.79
86 Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa. Biochem Biophys Res Commun 2012 0.79
87 Contribution of nitric oxide to CpG-mediated protection against Listeria monocytogenes. Infect Immun 2005 0.79
88 Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) enhanced inflammatory cytokine productions. Vaccine 2012 0.78
89 Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) induced IgG1 and IgG4 antibody responses in young children. Vaccine 2012 0.75
90 Synthesis and in vitro characterization of antigen-conjugated polysaccharide as a CpG DNA carrier. Bioconjug Chem 2006 0.75
91 Particulates Induce Type-2 Immune Responses. Nihon Eiseigaku Zasshi 2017 0.75
92 Development and application of next generation SE36 malaria vaccine formulated with a novel adjuvant: approach to travelers' vaccine. Yakugaku Zasshi 2013 0.75
93 [Vaccine adjuvant]. Nihon Rinsho 2011 0.75
94 Modulation of intracellular signaling using protein-transduction technology. Crit Rev Immunol 2010 0.75