PubRank

Thomas J Gardella

Author PubWeight™ 32.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol 2009 3.03
2 Retromer terminates the generation of cAMP by internalized PTH receptors. Nat Chem Biol 2011 1.88
3 Parathyroid hormone and parathyroid hormone-related peptide, and their receptors. Biochem Biophys Res Commun 2005 1.78
4 Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH. Proc Natl Acad Sci U S A 2013 1.68
5 Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. Mol Endocrinol 2007 1.57
6 Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. Proc Natl Acad Sci U S A 2008 1.45
7 Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J Biol Chem 2009 1.36
8 Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations. Mol Endocrinol 2005 1.36
9 Progress, paradox, and potential: parathyroid hormone research over five decades. Ann N Y Acad Sci 2007 1.31
10 Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Cell Mol Life Sci 2010 1.30
11 Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor. Mol Endocrinol 2003 1.04
12 Endosomal generation of cAMP in GPCR signaling. Nat Chem Biol 2014 1.03
13 Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptor. J Biol Chem 2004 0.99
14 Non-canonical signaling of the PTH receptor. Trends Pharmacol Sci 2012 0.95
15 Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs. J Biol Chem 2010 0.95
16 Role of amino acid side chains in region 17-31 of parathyroid hormone (PTH) in binding to the PTH receptor. J Biol Chem 2006 0.93
17 Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3. J Bone Miner Res 2004 0.90
18 C-terminal analogues of parathyroid hormone: effect of C-terminus function on helical structure, stability, and bioactivity. Biochemistry 2006 0.84
19 Residue 19 of the parathyroid hormone (PTH) modulates ligand interaction with the juxtamembrane region of the PTH-1 receptor. Biochemistry 2002 0.82
20 G protein-coupled receptor modulation with pepducins: moving closer to the clinic. Ann N Y Acad Sci 2011 0.82
21 Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol 2015 0.80
22 Backbone-methylated analogues of the principle receptor binding region of human parathyroid hormone. Evidence for binding to both the N-terminal extracellular domain and extracellular loop region. J Biol Chem 2005 0.79
23 Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141). Angew Chem Int Ed Engl 2012 0.79
24 Toward parathyroid hormone minimization: conformational studies of cyclic PTH(1-14) analogues. Biochemistry 2004 0.79
25 Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues. J Am Chem Soc 2012 0.78
26 Functional evidence for an intramolecular side chain interaction between residues 6 and 10 of receptor-bound parathyroid hormone analogues. Biochemistry 2003 0.77
27 Residue 19 of the parathyroid hormone: structural consequences. Biochemistry 2002 0.77
28 Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin. Am J Physiol Renal Physiol 2012 0.76
29 Cooperative interaction of arginine-19 and the N-terminal signaling domain in the affinity and potency of parathyroid hormone. Biochemistry 2004 0.76
30 Corrigendum: SIKs control osteocyte responses to parathyroid hormone. Nat Commun 2017 0.75