PubRank

J R Barrio

Author PubWeight™ 120.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc Natl Acad Sci U S A 2000 4.85
2 Fluorescent modification of adenosine-containing coenzymes. Biological activities and spectroscopic properties. Biochemistry 1972 4.06
3 A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci U S A 2000 3.28
4 Fluorescent adenosine and cytidine derivatives. Biochem Biophys Res Commun 1972 3.12
5 Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med 2001 3.03
6 Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci U S A 1999 2.71
7 Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir. J Nucl Med 1998 2.58
8 Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals. Gene Ther 1999 2.21
9 Imaging transgene expression with radionuclide imaging technologies. Neoplasia 2000 2.03
10 Noninvasive methods for quantitating blood time-activity curves from mouse PET images obtained with fluorine-18-fluorodeoxyglucose. J Nucl Med 1998 1.97
11 Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med 1992 1.83
12 8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET. J Nucl Med 2001 1.80
13 Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci 2001 1.73
14 Novel observations with FDOPA-PET imaging after early nigrostriatal damage. Mov Disord 2001 1.68
15 Synthesis of modified nucleoside 3',5'-bisphosphates and their incorporation into oligoribonucleotides with T4 RNA ligase. Biochemistry 1978 1.62
16 Assays for noninvasive imaging of reporter gene expression. Nucl Med Biol 1999 1.62
17 Monitoring gene therapy with reporter gene imaging. Semin Nucl Med 2001 1.56
18 Quantification of target gene expression by imaging reporter gene expression in living animals. Nat Med 2000 1.56
19 Chloroacetaldehyde-modified dinucleoside phosphates. Dynamic fluorescence quenching and quenching due to intramolecular complexation. Biochemistry 1974 1.54
20 In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile. Neuroscience 2003 1.38
21 Crystal and molecular structure of 3,N4-ethenocytidine hydrochloride. A study of the dimensions and molecular interactions of the fluorescent epsilon-cytidine system. J Am Chem Soc 1976 1.37
22 Species responsible for the fluorescence of 3,N4-ethenocytidine. J Am Chem Soc 1976 1.30
23 Fluorescent modification of adenosine 3',5'-monophosphate: spectroscopic properties and activity in enzyme systems. Science 1972 1.29
24 A fluorescent modification of adenosine triphosphate with activity in enzyme systems: 1,N 6 -ethenoadenosine triphosphate. Science 1972 1.24
25 Imaging gene expression: principles and assays. J Nucl Cardiol 1999 1.20
26 Seeing is believing: non-invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography. J Neurosci Res 2000 1.20
27 Quantifying local cerebral blood flow by N-isopropyl-p-[123I]iodoamphetamine (IMP) tomography. J Nucl Med 1982 1.17
28 Regioselective radiofluorodestannylation with [18F]F2 and [18F]CH3COOF: a high yield synthesis of 6-[18F]Fluoro-L-dopa. Int J Rad Appl Instrum A 1992 1.15
29 Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction. Gene Ther 2001 1.08
30 Species responsible for the fluorescence of 1:N6-ethenoadenosine. Eur J Biochem 1974 1.07
31 Whole body skeletal imaging with [18F]fluoride ion and PET. J Comput Assist Tomogr 1993 1.07
32 Defined dimensional changes in enzyme cofactors: fluorescent "stretched-out" analogs of adenine nucleotides. Science 1977 1.02
33 A fluorescent analog of nicotinamide adenine dinucleotide. Proc Natl Acad Sci U S A 1972 1.02
34 PET imaging of transgene expression. Biol Psychiatry 2000 1.01
35 FDDNP binding using MR derived cortical surface maps. Neuroimage 2009 1.01
36 Synthesis of 6-[18F] and 4-[18F]fluoro-L-m-tyrosines via regioselective radiofluorodestannylation. Appl Radiat Isot 1993 0.99
37 Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors. Gene Ther 2001 0.96
38 Synthesis of 8-[(18)F]fluoroguanine derivatives: in vivo probes for imaging gene expression with positron emission tomography. Nucl Med Biol 2000 0.96
39 Dimensional probes of the enzyme binding sites of adenine nucleotides. Biological effects of widening the adenine ring by 2.4 A. Biochemistry 1978 0.95
40 Flavin 1, N 6 -ethenoadenine dinucleotide: dynamic and static quenching of fluorescence. Proc Natl Acad Sci U S A 1973 0.94
41 Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease. Neurology 2007 0.94
42 Computer-controlled radiochemical synthesis: a chemistry process control unit for the automated production of radiochemicals. Int J Rad Appl Instrum A 1989 0.94
43 Neuroreceptor assay with positron emission tomography: equilibrium versus dynamic approaches. J Cereb Blood Flow Metab 1986 0.94
44 The crystal and molecular structure of a derivative of 1,N6-ethenoadenosine hydrochloride. Dimensions and molecular interactions of the fluorescent epsilon-adenosine (epsilon-ado) system. J Am Chem Soc 1974 0.93
45 Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene. Gene Ther 2002 0.92
46 A spray reagent for adenine-containing residues: detection by fluorescence. Biochim Biophys Acta 1972 0.92
47 Estimation of local cerebral protein synthesis rates with L-[1-11C]leucine and PET: methods, model, and results in animals and humans. J Cereb Blood Flow Metab 1989 0.92
48 Quantitative imaging of gene induction in living animals. Gene Ther 2001 0.91
49 Rapid synthesis of a 5'-fluorinated oligodeoxy-nucleotide: a model antisense probe for use in imaging with positron emission tomography (PET). Bioorg Med Chem Lett 1998 0.91
50 Remote, semiautomated production of 6-[18F]fluoro-L-dopa for human studies with PET. Int J Rad Appl Instrum A 1990 0.91
51 Estrogen use and brain metabolic change in older adults. A preliminary report. Psychiatry Res 2001 0.90
52 Fluorescent photoaffinity labeling: adenosine 3',5'-cyclic monophosphate receptor sites. Proc Natl Acad Sci U S A 1978 0.90
53 C-11 palmitate for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography. III. In vivo demonstration of the effects of substrate availability on myocardial metabolism. Am Heart J 1983 0.87
54 Attachment of a fluorescent label to 4-thiouracil and 4-thiouridine. Biochem Biophys Res Commun 1971 0.87
55 Quantitative measurement of local cerebral blood flow in humans by positron computed tomography and 15O-water. J Cereb Blood Flow Metab 1983 0.87
56 Estimation of rabbit myocardial metabolic rate for glucose using fluorodeoxyglucose. Am J Physiol 1982 0.86
57 Kinetic characterization of 13NH3 and [13N]glutamine metabolism in rabbit heart. Am J Physiol 1984 0.86
58 Functionalization of a viscosity-sensitive fluorophore for probing of biological systems. Bioorg Med Chem Lett 1998 0.86
59 Lymphoscintigraphy with Tc-99m-labeled dextran. J Nucl Med 1982 0.85
60 Specific and fluorescent modifications of cytidine. J Am Chem Soc 1973 0.85
61 C-11 palmitate for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. IV. In vivo evaluation of acute demand-induced ischemia in dogs. Am Heart J 1983 0.85
62 Effects of substrate availability on myocardial C-11 palmitate kinetics by positron emission tomography in normal subjects and patients with ventricular dysfunction. Am Heart J 1986 0.85
63 The effects of carbidopa administration on 6-[18F]fluoro-L-dopa kinetics in positron emission tomography. J Nucl Med 1992 0.84
64 In vivo cerebral protein synthesis rates with leucyl-transfer RNA used as a precursor pool: determination of biochemical parameters to structure tracer kinetic models for positron emission tomography. J Cereb Blood Flow Metab 1989 0.84
65 Kinetics and modeling of L-6-[18F]fluoro-dopa in human positron emission tomographic studies. J Cereb Blood Flow Metab 1991 0.84
66 Measurement of glucose and 2-deoxy-2-[18F]fluoro-D-glucose transport and phosphorylation rates in myocardium using dual-tracer kinetic experiments. FEBS Lett 1987 0.84
67 Enzymatic activity and - 32 P labeling of fluorescent derivatives of cytidine triphosphate and adenosine triphosphate. J Am Chem Soc 1973 0.84
68 Spectroscopic sensitivity of linear-benzoadenine nucleotides to divalent metal counterions, side chain conformations, micelles, and enzymes. Proc Natl Acad Sci U S A 1978 0.84
69 Dimensional probes of the enzyme binding sites of adenine nucleotides. Interaction of lin-benzoadenosine 5'-di- and triphosphate with mitochondrial ATP synthetase, purified ATPase, and the adenine nucleotide carrier. Biochemistry 1978 0.83
70 A double-injection technique for in vivo measurement of dopamine D2-receptor density in monkeys with 3-(2'-[18F]fluoroethyl)spiperone and dynamic positron emission tomography. J Cereb Blood Flow Metab 1989 0.83
71 13N-labeled L-amino acids for in vivo assessment of local myocardial metabolism. J Med Chem 1981 0.82
72 FLT-PET imaging of radiation responses in murine tumors. Mol Imaging Biol 2008 0.82
73 Maintenance of nitrogen balance in a young woman by substitution of -ketoisovaleric acid for valine. J Nutr 1971 0.82
74 Blood-brain barrier and neuronal membrane transport of 6-[18F]fluoro-L-DOPA. Biochem Pharmacol 2001 0.82
75 Effects of large neutral amino acid concentrations on 6-[F-18]Fluoro-L-DOPA kinetics. J Cereb Blood Flow Metab 1998 0.81
76 The assessment of the non-equilibrium effect in the 'Patlak analysis' of Fdopa PET studies. Phys Med Biol 1995 0.81
77 Automated image registration for FDOPA PET studies. Phys Med Biol 1996 0.81
78 The effects of carbidopa on the metabolism of 6-[18F]fluoro-L-dopa in rats, monkeys and humans. Life Sci 1990 0.80
79 L-[1-11C]leucine: routine synthesis by enzymatic resolution. J Nucl Med 1983 0.79
80 Nigrostriatal reduction of aromatic L-amino acid decarboxylase activity in MPTP-treated squirrel monkeys: in vivo and in vitro investigations. J Neurochem 2000 0.79
81 Methods for improving quantitation of putamen uptake constant of FDOPA in PET studies. J Nucl Med 1993 0.79
82 Allosteric activation of aspartate transcarbamylase with a fluorescent nucleotide analogue: linear-benzo-ATP. J Biol Chem 1978 0.79
83 Effect of lin-benzoadenosine and lin-benzoadenosine 3':5'-monophosphate on cyclic AMP-dependent protein kinase activity in vitro. J Cyclic Nucleotide Res 1978 0.79
84 Proton irradiation of [18O]O2: production of [18F]F2 and [18F]F2 + [18F] OF2. Nucl Med Biol 1996 0.79
85 2Beta-carbomethoxy-3beta-(4- and 2-[18F]fluoromethylphenyl)tropanes: specific probes for in vivo quantification of central dopamine transporter sites. Nucl Med Biol 1999 0.79
86 [1-(11)C]palmitic acid: improved radiopharmaceutical preparation. Int J Appl Radiat Isot 1982 0.78
87 Analysis of femtomole concentrations of alpha-ketoisocaproic acid in brain tissue by precolumn fluorescence derivatization with 4,5-dimethoxy-1,2-diaminobenzene. Anal Biochem 1993 0.78
88 The unit operations approach applied to the synthesis of [1(-11)C]2-deoxy-D-glucose for routine clinical applications. J Nucl Med 1982 0.78
89 Comparative in vivo metabolism of 6-[18F]fluoro-L-dopa and [3H]L-dopa in rats. Biochem Pharmacol 1990 0.78
90 3-(2'-[18F]fluoroethyl)spiperone, a potent dopamine antagonist: synthesis, structural analysis and in-vivo utilization in humans. Int J Rad Appl Instrum A 1990 0.78
91 Modelling approach for separating blood time-activity curves in positron emission tomographic studies. Phys Med Biol 1991 0.78
92 Criteria for the tracer kinetic measurement of cerebral protein synthesis in humans with positron emission tomography. Ann Neurol 1984 0.77
93 Distribution volume of 3-O-methyl-6. J Cereb Blood Flow Metab 2000 0.77
94 Synthesis and myocardial kinetics of N-13 and C-11 labeled branched-chain L-amino acids. J Nucl Med 1983 0.77
95 Metals suitable for fluorine gas target bodies: first use of aluminum for the production of [18F]F2. Nucl Med Biol 1996 0.77
96 The synthesis of 2-[F-18]fluoro-2-deoxy-D-glucose using glycals: a reexamination. J Nucl Med 1984 0.77
97 Chemical reactivity of the 18F electrophilic reagents from the 18O(p,n) 18F gas target systems. Nucl Med Biol 1996 0.76
98 Dynamic positron tomographic imaging with nitrogen-13 glutamate in patients with coronary artery disease: comparison with nitrogen-13 ammonia and fluorine-18 fluorodeoxyglucose imaging. J Am Coll Cardiol 1990 0.76
99 N-[18F]fluoro-N-alkylsulfonamides: novel reagents for mild and regioselective radiofluorination. Int J Rad Appl Instrum A 1990 0.76
100 Synthesis of 3beta-(4-[18F]fluoromethylphenyl)- and 3beta-(2-[18F] fluoromethylphenyl)tropane-2beta-carboxylic acid methyl esters: new ligands for mapping brain dopamine transporter with positron emission tomography. Nucl Med Biol 1999 0.76
101 Evaluation of myocardial metabolism, with N-13- and C-11-labeled amino acids and positron computed tomography. J Nucl Med 1982 0.76
102 No-carrier-added 3-(2'-[18F]fluoroethyl)spiperone, a new dopamine receptor-binding tracer for positron emission tomography. Int J Rad Appl Instrum B 1986 0.75
103 Enzymatic synthesis of [1-11C]pyruvic acid, L-[1-11C]lactic acid and L-[1-11C]alanine via DL-[1-11C]alanine. J Nucl Med 1984 0.75
104 Models for in vivo kinetic interactions of dopamine D2-neuroreceptors and 3-(2'-[18F]fluoroethyl)spiperone examined with positron emission tomography. J Cereb Blood Flow Metab 1989 0.75
105 Synthesis of 4-[18F]fluoro-L-m-tyrosine: a model analog for the in vivo assessment of central dopaminergic function. Int J Rad Appl Instrum A 1990 0.75
106 Assessment of dementia risk in aging adults using both FDG-PET and FDDNP-PET imaging. Int J Geriatr Psychiatry 2012 0.75
107 6-[18F]fluoro-L-dopa metabolism in MPTP-treated monkeys: assessment of tracer methodologies for positron emission tomography. Brain Res 1991 0.75
108 A direct method for the preparation of 2-hydroxyethoxymethyl derivatives of guanine, adenine, and cytosine. J Med Chem 1980 0.75
109 Effects of anoxia on kinetics of [13N] glutamate and 13NH3 metabolism in rabbit myocardium. Circ Res 1987 0.75
110 Remote, semiautomated production of F-18-labeled 2-deoxy-2-fluoro-D-glucose. J Nucl Med 1981 0.75
111 Compounds related to 2,4-dichlorophenoxyacetic acid and its derivatives. J Med Chem 1968 0.75
112 Identification and quantitation of gaseous compounds of fluorine generated in [18F]F2 target systems. Nucl Med Biol 1996 0.75
113 Production of [18F]F2 using the 16O(3He,p)18F reaction. Nucl Med Biol 1996 0.75
114 5-Cyclohexylmethyl-5-arylhydantoins. J Med Chem 1971 0.75
115 Distribution volume of radiolabeled large neutral amino acids in brain tissue. J Cereb Blood Flow Metab 1998 0.75
116 L-[4-11C]aspartic acid: enzymatic synthesis, myocardial uptake, and metabolism. J Med Chem 1982 0.75
117 L-6-[18F]fluoro-dopa metabolism in monkeys and humans: biochemical parameters for the formulation of tracer kinetic models with positron emission tomography. J Cereb Blood Flow Metab 1991 0.75
118 2,2'-dialkoxybenzhydrylamides and 2,2'-dialkylbenzhydryl esters of N,N-edisubstituted alpha-amino acids. Synthesis and pharmacological evaluation. J Med Chem 1971 0.75
119 14C-tracer studies in the benzilic acid type rearrangement of 1-phenyl- and 1-(4-methoxyphenyl)-2-(3-pyridyl) glyoxal. Tetrahedron Lett 1969 0.75
120 An automated high pressure reaction vessel for routine preparation of short-lived radiopharmaceuticals. Int J Rad Appl Instrum A 1986 0.75
121 Synthesis of stereo (R and S) and geometric (E and Z) isomers of [18F]fluoro-beta-fluoromethylene-m-tyrosine derivatives: in vivo probes of central dopaminergic function. Nucl Med Biol 1999 0.75
122 [18F]Fluoro-beta-fluoromethylene-m-tyrosine derivatives show stereo, geometrical, and regio specificities as in vivo central dopaminergic probes in monkeys. Nucl Med Biol 1999 0.75
123 2-(N,N-Dialkylamino)ethyl esters of alpha-(3-pyridyl)mandelic acids. Synthesis and pharmacological evaluation. J Med Chem 1969 0.75
124 Inhibition of adenylate kinase by P1-(lin-benzo-5'-adenosyl)-P4-(5'-adenosyl) tetraphosphate and P1-(lin-benzo-5'-adenosyl)-P5-(5'-adenosyl pentaphosphate. Biochemistry 1979 0.75
125 Striatal kinetic modeling of FDOPA with a cerebellar-derived constraint on the distribution of volume of 30MFD: a PET investigation using non-human primates. J Cereb Blood Flow Metab 2000 0.75
126 4-[18F]fluoro-L-m-tyrosine: an L-3,4-dihydroxyphenylalanine analog for probing presynaptic dopaminergic function with positron emission tomography. J Neurochem 1989 0.75
127 Stereospecific approach to the synthesis of [18F]2-deoxy-2-fluoro-D-mannose. Int J Rad Appl Instrum A 1986 0.75
128 Nitrogen-13 flux from L-[13N]glutamate in the isolated rabbit heart: effect of substrates and transaminase inhibition. Biochim Biophys Acta 1986 0.75