RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia.

PubWeight™: 0.88‹?›

🔗 View Article (PMID 15700772)

Published in Pharmazie on January 01, 2005

Authors

U Münster1, C Nakamura, A Haberland, K Jores, W Mehnert, S Rummel, M Schaller, H C Korting, Ch C Zouboulis, U Blume-Peytavi, M Schäfer-Korting

Author Affiliations

1: Pharmakologie und Toxikologie, Institut für Pharmazie, Freie Universität Berlin, Germany.

Articles by these authors

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci U S A (1992) 8.59

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J Biol Chem (1992) 4.33

Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism. Eur J Pharm Biopharm (1998) 2.44

PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis. Lancet (1998) 2.02

Successful treatment of severe refractory atopic dermatitis with mycophenolate mofetil. Br J Dermatol (1999) 1.96

Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts. J Cell Biol (1997) 1.78

Leukemia following chemotherapy for ovarian cancer. N Engl J Med (1990) 1.76

Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Mol Microbiol (1998) 1.70

Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol (1999) 1.69

Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm (2000) 1.58

The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol (2006) 1.55

Evidence of a leading role for VEGF in Bartonella henselae-induced endothelial cell proliferations. Cell Microbiol (2001) 1.48

Maintaining skin integrity in the aged: a systematic review. Br J Dermatol (2013) 1.47

Buschke-Ollendorff syndrome--differential diagnosis of disseminated connective tissue lesions. Eur J Dermatol (2001) 1.47

A phase I and pharmacologic evaluation of the DNA intercalator CI-958 in patients with advanced solid tumors. Clin Cancer Res (2000) 1.45

Occlusive paromomycin for cutaneous leishmaniasis. Lancet (1997) 1.43

Invasion of human keratinocytes by Staphylococcus aureus and intracellular bacterial persistence represent haemolysin-independent virulence mechanisms that are followed by features of necrotic and apoptotic keratinocyte cell death. Br J Dermatol (2002) 1.42

Analysis of quantitative changes in hair growth during treatment with chemotherapy or tamoxifen in patients with breast cancer: a cohort study. Br J Dermatol (2014) 1.39

[Axillary hyperhidrosis: successful treatment with botulinum toxin A]. Hautarzt (1998) 1.39

[Pyoderma]. Hautarzt (1998) 1.37

Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Proc Natl Acad Sci U S A (2003) 1.33

Involvement of cyclic AMP in the direct inotropic action of amrinone. Biochemical and functional evidence. Naunyn Schmiedebergs Arch Pharmacol (1981) 1.32

Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32

Personality and socialization correlates of vicarious emotional responding. J Pers Soc Psychol (1991) 1.29

Influence of serum protein binding on the in vitro activity of anti-fungal agents. Infection (1996) 1.23

Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals. Int J Pharm (2006) 1.22

Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J Control Release (2000) 1.21

Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol (2004) 1.19

Interaction of Bartonella henselae with endothelial cells results in rapid bacterial rRNA synthesis and replication. Cell Microbiol (2000) 1.19

Late cutaneous schistosomiasis representing an isolated skin manifestation of schistosoma mansoni infection. Dermatology (2000) 1.19

[Normal pH value of human skin]. Hautarzt (1986) 1.16

The relations of parental characteristics and practices to children's vicarious emotional responding. Child Dev (1991) 1.16

Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant. Pharm Res (1997) 1.16

Matting of hair: a multifactorial enigma. Dermatology (2000) 1.16

Empathy-based helping: is it selflessly or selfishly motivated? J Pers Soc Psychol (1987) 1.16

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis with membranous nephropathy in remission. Intern Med (1997) 1.15

Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes. Infect Immun (1993) 1.14

Influence of albumin on itraconazole and ketoconazole antifungal activity: results of a dynamic in vitro study. Antimicrob Agents Chemother (1991) 1.13

Hair follicles--an efficient storage and penetration pathway for topically applied substances. Summary of recent results obtained at the Center of Experimental and Applied Cutaneous Physiology, Charité -Universitätsmedizin Berlin, Germany. Skin Pharmacol Physiol (2008) 1.12

Gene transfer in magnetic bacteria: transposon mutagenesis and cloning of genomic DNA fragments required for magnetosome synthesis. J Bacteriol (1992) 1.11

An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. Naunyn Schmiedebergs Arch Pharmacol (2001) 1.11

The role and relevance of phospholipase D1 during growth and dimorphism of Candida albicans. Microbiology (2001) 1.09

Granulocyte colony-stimulating factor enhances pulmonary host defenses in normal and ethanol-treated rats. J Infect Dis (1991) 1.09

Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with poloxamine 908 and poloxamer 407. J Drug Target (1996) 1.09

Increased expression of Candida albicans secretory proteinase, a putative virulence factor, in isolates from human immunodeficiency virus-positive patients. J Clin Microbiol (1995) 1.07

Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis. J Invest Dermatol (2000) 1.07

Solid lipid nanoparticles (SLN) for controlled drug delivery. II. Drug incorporation and physicochemical characterization. J Microencapsul (1999) 1.06

New members of a cold-responsive group-3 Lea/Rab-related Cor gene family from common wheat (Triticum aestivum L.). Genes Genet Syst (2000) 1.05

Penetration profile of microspheres in follicular targeting of terminal hair follicles. J Invest Dermatol (2004) 1.05

Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients. Antimicrob Agents Chemother (1999) 1.05

Characterisation of penicillinase producing gonococci isolated in Munich, 1981-6. Genitourin Med (1988) 1.02

The role of sympathy and altruistic personality traits in helping: a reexamination. J Pers (1989) 1.02

Relationship between cervical curvature index (Ishihara) and cervical spine angle (C2--7). J Orthop Sci (2001) 1.01

Determination of R(+)- and S(-)-lansoprazole using chiral stationary-phase liquid chromatography and their enantioselective pharmacokinetics in humans. Pharm Res (1996) 1.01

1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. J Invest Dermatol (2001) 0.99

An observational cross-sectional survey of rosacea: clinical associations and progression between subtypes. Br J Dermatol (2013) 0.99

Epithelial cells and innate antifungal defense. J Dent Res (2010) 0.99

[Morphologic variants of genital ulcer caused by Haemophilus ducreyi]. Hautarzt (1989) 0.99

Improvement in the outcome of invasive fusariosis in the last decade. Clin Microbiol Infect (2013) 0.99

Cefodizime in serum and skin blister fluid after single intravenous and intramuscular doses in healthy volunteers. Antimicrob Agents Chemother (1987) 0.99

High-performance liquid chromatography analysis of porphyrins in Propionibacterium acnes. Arch Dermatol Res (2000) 0.98

Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicle. Arch Dermatol Res (1998) 0.98

Treatment of tinea unguium with medium and high doses of ultramicrosize griseofulvin compared with that with itraconazole. Antimicrob Agents Chemother (1993) 0.98

Levels of itraconazole in skin blister fluid after a single oral dose and during repetitive administration. J Am Acad Dermatol (1990) 0.98

The role of vitamin E in normal and damaged skin. J Mol Med (Berl) (1995) 0.97

Cyclosporine-loaded solid lipid nanoparticles (SLN): drug-lipid physicochemical interactions and characterization of drug incorporation. Eur J Pharm Biopharm (2007) 0.97

A cold-responsive wheat (Triticum aestivum L.) gene wcor14 identified in a winter-hardy cultivar 'Mironovska 808'. Genes Genet Syst (2000) 0.97

The role of Candida albicans secreted aspartic proteinase in the development of candidoses. J Mol Med (Berl) (1996) 0.96

Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis. Clin Exp Rheumatol (2002) 0.96

High-performance liquid chromatographic assay for the simultaneous determination of lansoprazole enantiomers and metabolites in human liver microsomes. J Chromatogr B Biomed Sci Appl (2001) 0.96

Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers. FASEB J (2000) 0.96

Antimicrobial susceptibility testing of dermatophytes--comparison of the agar macrodilution and broth microdilution tests. Chemotherapy (1998) 0.96

Is tinea unguium still widely incurable? A review three decades after the introduction of griseofulvin. Arch Dermatol (1992) 0.95

Reconstructed epidermis versus human and animal skin in skin absorption studies. Toxicol In Vitro (2005) 0.95

Current and future approaches to antimycotic treatment in the era of resistant fungi and immunocompromised hosts. Int J Antimicrob Agents (2001) 0.95

Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. Int J Cosmet Sci (2007) 0.95

Stratum corneum maturation. A review of neonatal skin function. Skin Pharmacol Physiol (2004) 0.95

Cefodizime penetration into skin suction blister fluid following a single intravenous dose. Eur J Clin Pharmacol (1986) 0.95

Dorfman-Chanarin syndrome in a Turkish kindred: conductor diagnosis requires analysis of multiple eosinophils. Acta Derm Venereol (2000) 0.95

Fulminant metastatic calcinosis with cutaneous necrosis in a child with end-stage renal disease and tertiary hyperparathyroidism. Br J Dermatol (1996) 0.95

Atenolol interaction with aspirin, allopurinol, and ampicillin. Clin Pharmacol Ther (1983) 0.94

The Staphylococcus aureus lipoprotein SitC colocalizes with Toll-like receptor 2 (TLR2) in murine keratinocytes and elicits intracellular TLR2 accumulation. Infect Immun (2010) 0.94

Genetic polymorphism of CYP2C19 and lansoprazole pharmacokinetics in Japanese subjects. Eur J Clin Pharmacol (1997) 0.94

Glass vials for small volume parenterals: influence of drug and manufacturing processes on glass delamination. Pharm Dev Technol (2001) 0.94

The KEX2 gene of Candida glabrata is required for cell surface integrity. Mol Microbiol (2001) 0.94

Onychomycosis. Mycoses (2007) 0.94

Aquarium dermatitis: cercarial dermatitis in an aquarist. Dermatology (1998) 0.93

Gastric antiulcerogenic effects of Stryphnodendron adstringens in rats. Phytother Res (1999) 0.92

Actinic keratosis: the key event in the evolution from photoaged skin to squamous cell carcinoma. Therapy based on pathogenetic and clinical aspects. Skin Pharmacol Physiol (2004) 0.92