Published in Int J Oncol on March 01, 2005
Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Perspect (2008) 1.32
Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility. J Med Chem (2013) 1.06
Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway. BMC Cancer (2014) 0.96
Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis. J Med Chem (2013) 0.92
Genomic and in vivo evidence of synergy of a herbal extract compared to its most active ingredient: Rabdosia rubescens vs. oridonin. Exp Ther Med (2010) 0.90
Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line. Int J Nanomedicine (2012) 0.90
Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer. Curr Drug Targets (2010) 0.89
Molecular Insight in the Multifunctional Effects of Oridonin. Drugs R D (2015) 0.84
ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids. Org Biomol Chem (2014) 0.84
Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells. World J Gastroenterol (2014) 0.80
Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway. Cancer Biol Ther (2012) 0.80
RGD-modified poly(D,L-lactic acid) nanoparticles enhance tumor targeting of oridonin. Int J Nanomedicine (2012) 0.80
Dual protective role of HO-1 in transplanted liver grafts: a review of experimental and clinical studies. World J Gastroenterol (2011) 0.79
Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi. Int J Mol Sci (2015) 0.78
Down-regulation of androgen-receptor and PSA by phytochemicals. Int J Oncol (2008) 0.78
Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway. Oncotarget (2016) 0.78
Tetrazolium violet induced apoptosis and cell cycle arrest in human lung cancer a549 cells. Biomol Ther (Seoul) (2012) 0.77
Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach. PLoS One (2012) 0.76
Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs. Cell Death Dis (2017) 0.75
The cell death of C6 astrocytoma cells induced by oridonin and its mechanism. Int J Clin Exp Pathol (2012) 0.75
Investigation of the anti‑asthmatic activity of Oridonin on a mouse model of asthma. Mol Med Rep (2016) 0.75
BUBR1 deficiency results in abnormal megakaryopoiesis. Blood (2003) 2.31
Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants. Cell Cycle (2006) 2.30
sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev Cell (2008) 2.12
Digital childhood: electronic media and technology use among infants, toddlers, and preschoolers. Pediatrics (2007) 2.05
Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin. Cytometry A (2004) 2.03
Analysis of cell cycle by flow cytometry. Methods Mol Biol (2004) 1.98
Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes. Cytometry A (2007) 1.95
Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. Mol Cancer Ther (2002) 1.88
High serum IL-21 levels after 12 weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B. J Hepatol (2011) 1.74
Cytometric assessment of histone H2AX phosphorylation: a reporter of DNA damage. Methods Mol Biol (2006) 1.68
Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyroid carcinoma cells. Cell Cycle (2011) 1.67
Apoptosis and beyond: cytometry in studies of programmed cell death. Methods Cell Biol (2011) 1.61
Liver fat content is associated with increased carotid atherosclerosis in a Chinese middle-aged and elderly population: the Shanghai Changfeng study. Atherosclerosis (2012) 1.60
Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents. Cytometry A (2007) 1.59
Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine. Cancer Biol Ther (2006) 1.57
Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis. Cell Prolif (2005) 1.56
Growth suppression of cervical carcinoma by pigment epithelium-derived factor via anti-angiogenesis. Cancer Biol Ther (2010) 1.55
Cytometric detection of chromatin relaxation, an early reporter of DNA damage response. Cell Cycle (2009) 1.55
Arsenic trioxide arrests cells early in mitosis leading to apoptosis. Cell Cycle (2002) 1.54
Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel. Cancer Biol Ther (2002) 1.50
RIalpha influences cellular proliferation in cancer cells by transporting RFC40 into the nucleus. Cancer Biol Ther (2005) 1.48
Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis. Cell Cycle (2005) 1.47
Sequential activation of caspases and serine proteases (serpases) during apoptosis. Cell Cycle (2002) 1.46
Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. Mol Cell Biol (2002) 1.44
Different rates of DNA replication at early versus late S-phase sections: multiscale modeling of stochastic events related to DNA content/EdU (5-ethynyl-2'deoxyuridine) incorporation distributions. Cytometry A (2014) 1.42
Cyclotherapy: protection of normal cells and unshielding of cancer cells. Cell Cycle (2003) 1.41
Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-independent effect. J Pharmacol Exp Ther (2002) 1.41
Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Dev Biol (2006) 1.41
DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis. Cell Cycle (2003) 1.38
Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase. Cell Cycle (2007) 1.34
SYTO probes in the cytometry of tumor cell death. Cytometry A (2008) 1.32
Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis. Cytometry A (2005) 1.31
Vertically Oriented Arrays of ReS2 Nanosheets for Electrochemical Energy Storage and Electrocatalysis. Nano Lett (2016) 1.28
Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete "sub-G1" peaks on DNA content histograms. Cytometry A (2007) 1.26
Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species. Int J Oncol (2006) 1.26
Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells. Circ Res (2003) 1.25
Induction of DNA damage response by the supravital probes of nucleic acids. Cytometry A (2009) 1.25
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging (Albany NY) (2012) 1.24
Isolation and characterization of a reovirus causing spleen necrosis in Pekin ducklings. Vet Microbiol (2011) 1.24
Dynamic analysis of apoptosis using cyanine SYTO probes: from classical to microfluidic cytometry. Exp Cell Res (2009) 1.23
Parent-child acculturation, parenting, and adolescent depressive symptoms in Chinese immigrant families. J Fam Psychol (2009) 1.23
2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX. Cell Cycle (2006) 1.21
Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. Aging (Albany NY) (2011) 1.21
Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells. Anal Chem (2009) 1.20
Ribonucleases as potential modalities in anticancer therapy. Eur J Pharmacol (2009) 1.16
Guidelines for the presentation of flow cytometric data. Methods Cell Biol (2004) 1.15
Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis. J Biol Chem (2006) 1.15
Multiparameter detection of apoptosis using red-excitable SYTO probes. Cytometry A (2008) 1.15
Laser scanning cytometry: principles and applications. Methods Mol Biol (2006) 1.14
Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry". Cytometry A (2011) 1.14
Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Biochem Biophys Res Commun (2004) 1.13
Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes. Cell Cycle (2006) 1.13
Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis. Cytometry A (2006) 1.13
Two isotypic transition metal germanophosphates M(II)4(H2O)4[Ge(OH)2(HPO4)2(PO4)2] (M(II) = Fe, Co): synthesis, structure, Mössbauer spectroscopy, and magnetic properties. Inorg Chem (2012) 1.12
Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J Pharmacol Sci (2010) 1.12
Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide. Cytometry A (2011) 1.12
Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone. Mutat Res (2008) 1.11
Developing photoactive affinity probes for proteomic profiling: hydroxamate-based probes for metalloproteases. J Am Chem Soc (2004) 1.11
NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property? Biochem Pharmacol (2004) 1.10
Biofilm formation of the pathogens of fatal bacterial granuloma after trauma: potential mechanism underlying the failure of traditional antibiotic treatments. Scand J Infect Dis (2007) 1.09
Enhancive effects of Lewis y antigen on CD44-mediated adhesion and spreading of human ovarian cancer cell line RMG-I. J Exp Clin Cancer Res (2011) 1.08