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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice.
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Neuron
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2005
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6.20
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3
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Intracellular amyloid-beta in Alzheimer's disease.
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2007
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4
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Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.
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J Neurosci
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2005
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3.18
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Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.
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Proc Natl Acad Sci U S A
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2009
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2.96
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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
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2009
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2.16
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M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
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2006
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2.07
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A dynamic relationship between intracellular and extracellular pools of Abeta.
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2006
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1.66
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Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
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2012
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1.60
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Abeta inhibits the proteasome and enhances amyloid and tau accumulation.
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1.58
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Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease.
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Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals.
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Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease.
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Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
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1.28
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17
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Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice.
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J Neurosci
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1.22
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18
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Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
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Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.
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Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia.
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Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.
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Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice.
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Am J Pathol
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Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.
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APP knockout mice experience acute mortality as the result of ischemia.
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Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.
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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.
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Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways.
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Brain Res Mol Brain Res
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Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing.
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Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
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Presenilins mediate efficient proteolysis via the autophagosome-lysosome system.
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Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential.
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Amyloid peptide-mediated hypoxic regulation of Ca2+ channels in PC12 cells.
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0.75
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