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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
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Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation.
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2.04
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4
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The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores.
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Cell Metab
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2005
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1.83
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5
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The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression.
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6
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Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways.
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FEBS J
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2008
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7
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The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP.
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Nucleic Acids Res
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2007
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1.14
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8
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ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation.
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Nucleic Acids Res
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2007
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1.09
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9
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Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway.
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PLoS One
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2010
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1.07
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10
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Identification of a novel amino acid response pathway triggering ATF2 phosphorylation in mammals.
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1.01
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11
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Molecular mechanisms involved in the adaptation to amino acid limitation in mammals.
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12
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Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP.
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13
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Amino acids as regulators of gene expression in mammals: molecular mechanisms.
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14
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Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR.
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FEBS Lett
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2005
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15
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Identification of GCN2 as new redox regulator for oxidative stress prevention in vivo.
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16
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Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes.
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2008
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0.77
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17
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The amino acid sensor GCN2 biases macronutrient selection during aging.
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