Helen E Heslop

Author PubWeight™ 205.86‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med 2008 11.49
2 CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J Clin Invest 2011 6.38
3 Inducible apoptosis as a safety switch for adoptive cell therapy. N Engl J Med 2011 6.14
4 Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med 2006 4.42
5 Treatment of nasopharyngeal carcinoma with Epstein-Barr virus--specific T lymphocytes. Blood 2004 4.01
6 Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Blood 2007 3.94
7 Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood 2011 3.82
8 Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteins. J Clin Oncol 2013 3.65
9 Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease. J Exp Med 2004 3.57
10 Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood 2009 3.27
11 A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther 2005 3.18
12 An inducible caspase 9 safety switch for T-cell therapy. Blood 2005 2.93
13 CARs on track in the clinic. Mol Ther 2011 2.86
14 Post-transplant lymphoproliferative disorders. Annu Rev Med 2005 2.82
15 T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood 2009 2.79
16 T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood 2006 2.68
17 Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood 2007 2.50
18 Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation. Blood 2009 2.47
19 Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biol Blood Marrow Transplant 2007 2.33
20 Adoptive T cell therapy of cancer. Curr Opin Immunol 2010 2.13
21 Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study. Blood 2013 2.13
22 Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes. Blood 2007 2.11
23 Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects. Blood 2010 2.06
24 Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity. Blood 2002 1.98
25 Impending challenges in the hematopoietic stem cell transplantation physician workforce. Biol Blood Marrow Transplant 2009 1.97
26 Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation. Blood 2013 1.95
27 Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation. Blood 2006 1.93
28 Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies. Blood 2002 1.89
29 Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex). J Immunother 2010 1.81
30 Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs). Blood 2006 1.75
31 Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytes. J Exp Med 2004 1.72
32 Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections. Mol Ther 2012 1.72
33 Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood 2011 1.72
34 Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy. J Virol 2007 1.70
35 Improving T-cell therapy for relapsed EBV-negative Hodgkin lymphoma by targeting upregulated MAGE-A4. Clin Cancer Res 2011 1.70
36 HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors. Clin Cancer Res 2010 1.65
37 Antigen-specific cytotoxic T lymphocytes can target chemoresistant side-population tumor cells in Hodgkin lymphoma. Leuk Lymphoma 2010 1.64
38 Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res 2007 1.58
39 Prompt versus preemptive intervention for EBV lymphoproliferative disease. Blood 2004 1.57
40 Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses. Blood 2003 1.55
41 Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients. Blood 2008 1.52
42 Adoptive transfer of EBV-specific T cells results in sustained clinical responses in patients with locoregional nasopharyngeal carcinoma. J Immunother 2010 1.50
43 Safer CARS. Mol Ther 2010 1.46
44 In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation. Leuk Lymphoma 2006 1.46
45 Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation. Blood 2010 1.44
46 Characterization of latent membrane protein 2 specificity in CTL lines from patients with EBV-positive nasopharyngeal carcinoma and lymphoma. J Immunol 2005 1.42
47 Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection. Blood 2002 1.40
48 Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression. Mol Ther 2009 1.40
49 Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506). Blood 2009 1.39
50 Safety and clinical efficacy of rapidly-generated trivirus-directed T cells as treatment for adenovirus, EBV, and CMV infections after allogeneic hematopoietic stem cell transplant. Mol Ther 2013 1.38
51 Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy. J Immunother 2003 1.37
52 T-cell therapy in the treatment of post-transplant lymphoproliferative disease. Nat Rev Clin Oncol 2012 1.36
53 Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients. Am J Transplant 2005 1.36
54 Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host. Mol Ther 2009 1.36
55 Comparable outcome of alternative donor and matched sibling donor hematopoietic stem cell transplant for children with acute lymphoblastic leukemia in first or second remission using alemtuzumab in a myeloablative conditioning regimen. Biol Blood Marrow Transplant 2008 1.35
56 The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease. J Immunother 2004 1.35
57 Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7. Mol Ther 2009 1.35
58 Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia. Blood 2008 1.33
59 Adoptive immunotherapy for EBV-associated malignancies. Leuk Lymphoma 2005 1.30
60 High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells. Blood 2011 1.29
61 Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor. J Immunother 2008 1.25
62 Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma. Mol Ther 2013 1.25
63 An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies. Stem Cells 2010 1.23
64 Preparing for growth: current capacity and challenges in hematopoietic stem cell transplantation programs. Biol Blood Marrow Transplant 2010 1.20
65 Comparable outcomes of matched-related and alternative donor stem cell transplantation for pediatric severe aplastic anemia. Biol Blood Marrow Transplant 2006 1.18
66 Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity. Clin Cancer Res 2014 1.17
67 TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy. Mol Ther Nucleic Acids 2013 1.16
68 Identification of HLA-DP3-restricted peptides from EBNA1 recognized by CD4(+) T cells. Cancer Res 2002 1.15
69 Cellular immunity to Epstein-Barr virus in liver transplant recipients treated with rituximab for post-transplant lymphoproliferative disease. Am J Transplant 2005 1.13
70 Genetic modification of T cells. Biol Blood Marrow Transplant 2011 1.10
71 Adoptive immunotherapy for posttransplantation viral infections. Biol Blood Marrow Transplant 2004 1.07
72 Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: implications for adoptive T cell-based therapies for lymphoma. Clin Cancer Res 2012 1.06
73 Generation of EBV-specific CD4+ cytotoxic T cells from virus naive individuals. J Immunol 2002 1.06
74 Hematopoietic and immunomodulatory effects of lytic CD45 monoclonal antibodies in patients with hematologic malignancy. Biol Blood Marrow Transplant 2003 1.05
75 Generation of polyclonal CMV-specific T cells for the adoptive immunotherapy of glioblastoma. J Immunother 2012 1.04
76 A strategy for treatment of Epstein-Barr virus-positive Hodgkin's disease by targeting interleukin 12 to the tumor environment using tumor antigen-specific T cells. Cancer Gene Ther 2004 1.02
77 A phase 2/3 multicenter randomized clinical trial of ABX-CBL versus ATG as secondary therapy for steroid-resistant acute graft-versus-host disease. Blood 2006 1.02
78 Immunotherapeutic strategies to prevent and treat human herpesvirus 6 reactivation after allogeneic stem cell transplantation. Blood 2012 1.00
79 Expansion of T cells targeting multiple antigens of cytomegalovirus, Epstein-Barr virus and adenovirus to provide broad antiviral specificity after stem cell transplantation. Cytotherapy 2011 0.98
80 Production of good manufacturing practice-grade cytotoxic T lymphocytes specific for Epstein-Barr virus, cytomegalovirus and adenovirus to prevent or treat viral infections post-allogeneic hematopoietic stem cell transplant. Cytotherapy 2012 0.98
81 Cytotoxic T lymphocytes simultaneously targeting multiple tumor-associated antigens to treat EBV negative lymphoma. Mol Ther 2011 0.97
82 Ex vivo gene transfer for improved adoptive immunotherapy of cancer. Hum Mol Genet 2011 0.97
83 Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment. PLoS One 2011 0.97
84 Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation. Blood 2005 0.96
85 Assessing the safety of cytotoxic T lymphocytes transduced with a dominant negative transforming growth factor-beta receptor. J Immunother 2006 0.95
86 Cytotoxic T lymphocytes as immune-therapy in haematological practice. Br J Haematol 2008 0.95
87 Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements? Mol Ther 2012 0.94
88 Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience. Cytotherapy 2010 0.94
89 Excellent survival after sibling or unrelated donor stem cell transplantation for chronic granulomatous disease. J Allergy Clin Immunol 2011 0.94
90 Adoptive T-cell transfer in cancer immunotherapy. Immunol Cell Biol 2006 0.93
91 Allogeneic haematopoietic cell transplantation for myelofibrosis in 30 patients 60-78 years of age. Br J Haematol 2011 0.93
92 Survivin-specific T cell receptor targets tumor but not T cells. J Clin Invest 2014 0.91
93 Antiviral T-cell therapy. Immunol Rev 2014 0.91
94 A single institution experience with pediatric nasopharyngeal carcinoma: high incidence of toxicity associated with platinum-based chemotherapy plus IMRT. J Pediatr Hematol Oncol 2007 0.91
95 Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies. J Immunother 2013 0.90
96 Treatment of Epstein-Barr virus-associated malignancies with specific T cells. Adv Cancer Res 2002 0.90
97 The costs and cost-effectiveness of allogeneic peripheral blood stem cell transplantation versus bone marrow transplantation in pediatric patients with acute leukemia. Biol Blood Marrow Transplant 2010 0.90
98 Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection. Clin Transplant 2006 0.89
99 Immunotherapy for Epstein-Barr virus-associated cancers in children. Oncologist 2003 0.89
100 Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease. Haematologica 2012 0.89
101 Immunotherapy for post-transplant lymphoproliferative disease. Br J Haematol 2002 0.89
102 Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the prevention and treatment of EBV-associated post-transplant lymphomas. Recent Results Cancer Res 2002 0.88
103 Complementation of antigen-presenting cells to generate T lymphocytes with broad target specificity. J Immunother 2014 0.88
104 Successful treatment of stem cell graft failure in pediatric patients using a submyeloablative regimen of campath-1H and fludarabine. Biol Blood Marrow Transplant 2008 0.87
105 Exploiting cytokine secretion to rapidly produce multivirus-specific T cells for adoptive immunotherapy. J Immunother 2008 0.87
106 Posttransplant lymphoproliferative disease following liver transplantation. Curr Opin Organ Transplant 2011 0.87
107 Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man. Ann N Y Acad Sci 2003 0.87
108 Immunotherapy targeting EBV-expressing lymphoproliferative diseases. Best Pract Res Clin Haematol 2008 0.86
109 Plasma markers of B-cell activation and clonality in pediatric liver and hematopoietic stem cell transplant recipients. Transplantation 2013 0.86
110 Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients. Clin Transplant 2006 0.86
111 Clinical responses with T lymphocytes targeting malignancy-associated κ light chains. J Clin Invest 2016 0.85
112 Haemopoietic stem cell transplantation for acute lymphoblastic leukaemia. Cancer Treat Rev 2003 0.84
113 Adoptive T-cell therapy for EBV-associated post-transplant lymphoproliferative disease. Acta Haematol 2003 0.84
114 Hemolytic uremic syndrome after bone marrow transplantation: clinical characteristics and outcome in children. Biol Blood Marrow Transplant 2005 0.83
115 Children with acute leukemia: a comparison of outcomes from allogeneic blood stem cell and bone marrow transplantation. Pediatr Blood Cancer 2011 0.83
116 Intravenous Cidofovir therapy for disseminated adenovirus in a pediatric liver transplant recipient. Transplantation 2002 0.82
117 Treatment of Epstein-Barr virus lymphoproliferative disease after hematopoietic stem-cell transplantation with hydroxyurea and cytotoxic T-cell lymphocytes. Transplantation 2004 0.82
118 Diagnosis and treatment of posttransplantation lymphoproliferative disease after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2002 0.82
119 Computer-assisted quantitative evaluation of therapeutic responses for lymphoma using serial PET/CT imaging. Acad Radiol 2010 0.81
120 Administration of latent membrane protein 2-specific cytotoxic T lymphocytes to patients with relapsed Epstein-Barr virus-positive lymphoma. Clin Lymphoma Myeloma 2006 0.80
121 T lymphocytes targeting native receptors. Immunol Rev 2014 0.80
122 T cell therapy in allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2008 0.80
123 Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression. Mol Cancer 2009 0.80
124 T-cell-based therapies for malignancy and infection in childhood. Pediatr Clin North Am 2010 0.80
125 Immunotherapy for epstein-barr virus-related lymphomas. Mediterr J Hematol Infect Dis 2009 0.79
126 Epstein-Barr virus lymphoproliferative disease after hematopoietic stem cell transplant. Curr Opin Hematol 2014 0.78
127 Viral lymphomagenesis. Curr Opin Hematol 2006 0.78
128 Transfusion-related acute lung injury (TRALI) following allogeneic stem cell transplant for acute myeloid leukemia. Am J Hematol 2004 0.78
129 New ISSCR guidelines: clinical translation of stem cell research. Lancet 2016 0.77
130 Immunotherapy to reconstitute immunity to DNA viruses. Semin Hematol 2002 0.77
131 Guidance for developing phase II cell therapy trial proposals for consideration by the Blood and Marrow Transplant Clinical Trials Network. Biol Blood Marrow Transplant 2010 0.76
132 Adoptive cellular therapy with T cells specific for EBV-derived tumor antigens. Update Cancer Ther 2008 0.75
133 Commentary on journal of immunotherapy paper by melenhorst et al. J Immunother 2006 0.75
134 Aggressive peripheral CD70-positive T-cell lymphoma associated with severe chronic active EBV infection. Pediatr Blood Cancer 2011 0.75
135 Genetically engineered T-cells for adoptive immunotherapy. Curr Opin Mol Ther 2002 0.75
136 Adoptive T-cell therapy for Epstein-Barr virus-positive Hodgkin's disease. Acta Haematol 2003 0.75
137 New approaches in alternative donor transplantation. Biol Blood Marrow Transplant 2012 0.75