PubRank

J Christopher Gorski

Author PubWeight™ 24.17‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther 2003 3.71
2 Indinavir impairs endothelial function in healthy HIV-negative men. Am Heart J 2005 1.71
3 Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Hepatology 2003 1.65
4 Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole. Drug Metab Dispos 2006 1.27
5 Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer. Clin Cancer Res 2006 1.23
6 Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin. Drug Metab Dispos 2009 1.11
7 The interaction between St John's wort and an oral contraceptive. Clin Pharmacol Ther 2003 1.10
8 The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates. Clin Pharmacol Ther 2006 1.02
9 Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression. Clin Pharmacol Ther 2005 0.99
10 Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite. Drug Metab Dispos 2009 0.99
11 Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin. Drug Metab Dispos 2002 0.88
12 Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics. Hepatology 2005 0.87
13 The effects of an oral contraceptive containing ethinyloestradiol and norgestrel on CYP3A activity. Br J Clin Pharmacol 2002 0.87
14 Insulin sensitivity is preserved despite disrupted endothelial function. Am J Physiol Endocrinol Metab 2006 0.85
15 Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance. Drug Metab Dispos 2005 0.85
16 Interaction between midazolam and clarithromycin in the elderly. Br J Clin Pharmacol 2007 0.83
17 Effect of cirrhosis and liver transplantation on the gender difference in QT interval. Am J Cardiol 2005 0.83
18 Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin. Eur J Clin Pharmacol 2012 0.82
19 Intramuscular haloperidol or lorazepam and QT intervals in schizophrenia. J Clin Pharmacol 2004 0.78
20 Effects of commonly administered agents and genetics on nebivolol pharmacokinetics: drug-drug interaction studies. J Clin Pharmacol 2010 0.77
21 Evaluation of partial area under the concentration time curve to estimate midazolam apparent oral clearance for cytochrome P450 3A phenotyping. Drug Metabol Drug Interact 2013 0.77
22 Furosemide responsiveness, non-adherence and resistance during the chronic treatment of heart failure: a longitudinal study. Br J Clin Pharmacol 2004 0.76