Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity.
|
J Pharmacol Exp Ther
|
2003
|
3.71
|
2
|
Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America.
|
Clin Infect Dis
|
2005
|
3.63
|
3
|
Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity.
|
Gastroenterology
|
2004
|
3.27
|
4
|
Mechanism-based inactivation of CYP3A by HIV protease inhibitors.
|
J Pharmacol Exp Ther
|
2004
|
1.89
|
5
|
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.
|
Hepatology
|
2003
|
1.65
|
6
|
Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions.
|
PLoS Comput Biol
|
2012
|
1.58
|
7
|
Airflows around oxygen masks: A potential source of infection?
|
Chest
|
2006
|
1.53
|
8
|
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.
|
Drug Metab Dispos
|
2002
|
1.52
|
9
|
Drug interactions with herbal products and grapefruit juice: a conference report.
|
Clin Pharmacol Ther
|
2004
|
1.51
|
10
|
The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo.
|
Clin Pharmacol Ther
|
2004
|
1.44
|
11
|
Exhaled air dispersion distances during noninvasive ventilation via different Respironics face masks.
|
Chest
|
2009
|
1.41
|
12
|
Drug-induced QT prolongation in cirrhotic patients with transjugular intrahepatic portosystemic shunt.
|
J Clin Gastroenterol
|
2011
|
1.38
|
13
|
GLM-beamformer method demonstrates stationary field, alpha ERD and gamma ERS co-localisation with fMRI BOLD response in visual cortex.
|
Neuroimage
|
2005
|
1.35
|
14
|
Effect of St John's wort on the pharmacokinetics of fexofenadine.
|
Clin Pharmacol Ther
|
2002
|
1.28
|
15
|
Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole.
|
Drug Metab Dispos
|
2006
|
1.27
|
16
|
Selective metabolism of vincristine in vitro by CYP3A5.
|
Drug Metab Dispos
|
2006
|
1.26
|
17
|
Effect of race on vincristine-associated neurotoxicity in pediatric acute lymphoblastic leukemia patients.
|
Pediatr Blood Cancer
|
2008
|
1.18
|
18
|
Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia.
|
Pediatr Blood Cancer
|
2010
|
1.18
|
19
|
The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity.
|
Clin Pharmacol Ther
|
2003
|
1.13
|
20
|
Noninvasive positive-pressure ventilation: An experimental model to assess air and particle dispersion.
|
Chest
|
2006
|
1.13
|
21
|
Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans.
|
Br J Clin Pharmacol
|
2003
|
1.11
|
22
|
Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin.
|
Drug Metab Dispos
|
2009
|
1.11
|
23
|
Drug-drug interaction prediction: a Bayesian meta-analysis approach.
|
Stat Med
|
2007
|
1.08
|
24
|
Association between the CYP3A5 genotype and blood pressure.
|
Hypertension
|
2004
|
1.07
|
25
|
Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes.
|
Drug Metab Dispos
|
2002
|
1.06
|
26
|
Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes.
|
J Pharmacol Exp Ther
|
2007
|
1.04
|
27
|
Sustained neuronal activity generated by glial plasticity.
|
J Neurosci
|
2011
|
1.03
|
28
|
The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates.
|
Clin Pharmacol Ther
|
2006
|
1.02
|
29
|
The influence of L-glutamine on the depression of hepatic cytochrome P450 activity in male rats caused by total parenteral nutrition.
|
Drug Metab Dispos
|
2002
|
1.01
|
30
|
The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis.
|
AIDS
|
2008
|
0.99
|
31
|
Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite.
|
Drug Metab Dispos
|
2009
|
0.99
|
32
|
Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression.
|
Clin Pharmacol Ther
|
2005
|
0.99
|
33
|
Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity.
|
Clin Gastroenterol Hepatol
|
2007
|
0.99
|
34
|
Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites.
|
Drug Metab Dispos
|
2004
|
0.96
|
35
|
Computational approaches that predict metabolic intermediate complex formation with CYP3A4 (+b5).
|
Drug Metab Dispos
|
2007
|
0.96
|
36
|
Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines.
|
Biochem Pharmacol
|
2006
|
0.95
|
37
|
Literature mining on pharmacokinetics numerical data: a feasibility study.
|
J Biomed Inform
|
2009
|
0.93
|
38
|
In vivo real-time 3-D intracardiac echo using PMUT arrays.
|
IEEE Trans Ultrason Ferroelectr Freq Control
|
2014
|
0.92
|
39
|
Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition.
|
Drug Metab Dispos
|
2008
|
0.91
|
40
|
A general linear model for MEG beamformer imaging.
|
Neuroimage
|
2004
|
0.91
|
41
|
Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients.
|
Ann Surg
|
2013
|
0.90
|
42
|
Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.
|
Drug Metab Dispos
|
2012
|
0.89
|
43
|
Exhaled air dispersion during oxygen delivery via a simple oxygen mask.
|
Chest
|
2007
|
0.89
|
44
|
Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation.
|
Biochem Pharmacol
|
2012
|
0.88
|
45
|
Effect of rosiglitazone on serum liver biochemistries in diabetic patients with normal and elevated baseline liver enzymes.
|
Am J Gastroenterol
|
2005
|
0.88
|
46
|
Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil.
|
Drug Metab Dispos
|
2005
|
0.88
|
47
|
Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin.
|
Drug Metab Dispos
|
2002
|
0.88
|
48
|
Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics.
|
Hepatology
|
2005
|
0.87
|
49
|
The effects of an oral contraceptive containing ethinyloestradiol and norgestrel on CYP3A activity.
|
Br J Clin Pharmacol
|
2002
|
0.87
|
50
|
Quantitative structure-activity relationship models of clinical pharmacokinetics: clearance and volume of distribution.
|
J Chem Inf Model
|
2013
|
0.86
|
51
|
A new probabilistic rule for drug-dug interaction prediction.
|
J Pharmacokinet Pharmacodyn
|
2009
|
0.86
|
52
|
Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance.
|
Drug Metab Dispos
|
2005
|
0.85
|
53
|
Oscillatory beta activity mediates neuroplastic effects of motor cortex stimulation in humans.
|
J Neurosci
|
2013
|
0.85
|
54
|
Airflow and droplet spreading around oxygen masks: a simulation model for infection control research.
|
Am J Infect Control
|
2007
|
0.85
|
55
|
Quantification of vincristine and its major metabolite in human plasma by high-performance liquid chromatography/tandem mass spectrometry.
|
Ther Drug Monit
|
2008
|
0.84
|
56
|
Enriching amnestic mild cognitive impairment populations for clinical trials: optimal combination of biomarkers to predict conversion to dementia.
|
J Alzheimers Dis
|
2012
|
0.83
|
57
|
Interaction between midazolam and clarithromycin in the elderly.
|
Br J Clin Pharmacol
|
2007
|
0.83
|
58
|
Exhaled air and aerosolized droplet dispersion during application of a jet nebulizer.
|
Chest
|
2009
|
0.83
|
59
|
Effect of cirrhosis and liver transplantation on the gender difference in QT interval.
|
Am J Cardiol
|
2005
|
0.83
|
60
|
Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin.
|
Eur J Clin Pharmacol
|
2012
|
0.82
|
61
|
Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes.
|
J Pharmacol Exp Ther
|
2008
|
0.82
|
62
|
Optimization of drug-drug interaction study design: comparison of minimal physiologically based pharmacokinetic models on prediction of CYP3A inhibition by ketoconazole.
|
Drug Metab Dispos
|
2013
|
0.82
|
63
|
Primary and secondary somatosensory cortex responses to anticipation and pain: a magnetoencephalography study.
|
Eur J Neurosci
|
2011
|
0.82
|
64
|
A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes.
|
Proteomics
|
2008
|
0.82
|
65
|
Irreversible enzyme inhibition kinetics and drug-drug interactions.
|
Methods Mol Biol
|
2014
|
0.81
|
66
|
A novel Gibbs maximum a posteriori (GMAP) approach on Bayesian nonlinear mixed-effects population pharmacokinetics (PK) models.
|
J Biopharm Stat
|
2009
|
0.81
|
67
|
The effect of anesthesia and surgery on CYP3A activity in rats.
|
Drug Metab Dispos
|
2004
|
0.81
|
68
|
The relative contributions of CYP3A4 and CYP3A5 to the metabolism of vinorelbine.
|
Drug Metab Dispos
|
2013
|
0.81
|
69
|
CYP2B6 pharmacogenetics-based in vitro-in vivo extrapolation of efavirenz clearance by physiologically based pharmacokinetic modeling.
|
Drug Metab Dispos
|
2013
|
0.80
|
70
|
A multimodal perspective on the composition of cortical oscillations.
|
Front Hum Neurosci
|
2013
|
0.80
|
71
|
Relative contributions of presystemic and systemic peptidases to oral exposure of a novel metabotropic glutamate 2/3 receptor agonist (LY404039) after oral administration of prodrug pomaglumetad methionil (LY2140023).
|
J Pharm Sci
|
2014
|
0.79
|
72
|
Inhibition of CYP3A by erythromycin: in vitro-in vivo correlation in rats.
|
Drug Metab Dispos
|
2010
|
0.79
|
73
|
Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.
|
Drug Metab Dispos
|
2012
|
0.78
|
74
|
A phase I dose escalation and pharmacokinetic study of vatalanib (PTK787/ZK 222584) in combination with paclitaxel in patients with advanced solid tumors.
|
Cancer Chemother Pharmacol
|
2009
|
0.78
|
75
|
Hydroxyitraconazole, formed during intestinal first-pass metabolism of itraconazole, controls the time course of hepatic CYP3A inhibition and the bioavailability of itraconazole in rats.
|
Drug Metab Dispos
|
2008
|
0.77
|
76
|
Drug-drug interaction prediction assessment.
|
J Biopharm Stat
|
2009
|
0.77
|
77
|
Hemodialysis does not significantly affect the pharmacokinetics of nevirapine in HIV-1-infected persons requiring hemodialysis: results from ACTG A5177.
|
J Acquir Immune Defic Syndr
|
2010
|
0.76
|
78
|
Live volumetric imaging (LVI) intracardiac ultrasound catheter.
|
Cardiovasc Revasc Med
|
2013
|
0.76
|
79
|
Prediction of CYP3A-mediated drug-drug interactions using human hepatocytes suspended in human plasma.
|
Drug Metab Dispos
|
2011
|
0.76
|
80
|
QT effect of semagacestat at therapeutic and supratherapeutic doses.
|
Int J Clin Pharmacol Ther
|
2012
|
0.75
|
81
|
The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor, ketoconazole.
|
Drug Metab Dispos
|
2012
|
0.75
|