|
1
|
Assay development and data analysis of receptor-ligand binding based on scintillation proximity assay.
|
Metab Eng
|
2005
|
0.85
|
|
2
|
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
|
J Med Chem
|
2011
|
0.83
|
|
3
|
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.
|
Bioorg Med Chem Lett
|
2008
|
0.81
|
|
4
|
A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells.
|
Cancer Lett
|
2011
|
0.81
|
|
5
|
Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.
|
J Med Chem
|
2010
|
0.78
|
|
6
|
Solution-phase parallel synthesis of Hsp90 inhibitors.
|
J Comb Chem
|
2009
|
0.77
|