Published in Stroke on March 10, 2005
Normobaric Oxygen Therapy in Acute Ischemic Stroke Trial | NCT00414726
Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med (2009) 3.35
Standardized prehospital treatment of stroke. Dtsch Arztebl Int (2011) 2.21
Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain (2007) 1.92
Application of medical gases in the field of neurobiology. Med Gas Res (2011) 1.64
Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia. J Neurochem (2009) 1.53
RODENT STROKE MODEL GUIDELINES FOR PRECLINICAL STROKE TRIALS (1ST EDITION). J Exp Stroke Transl Med (2009) 1.49
Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke? Med Gas Res (2016) 1.42
Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death. J Cereb Blood Flow Metab (2006) 1.36
Early changes in physiological variables after stroke. Ann Indian Acad Neurol (2008) 1.17
Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. J Biol Chem (2009) 1.17
Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity. Free Radic Biol Med (2006) 1.15
Experimental models, neurovascular mechanisms and translational issues in stroke research. Br J Pharmacol (2007) 1.14
Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature. Med Gas Res (2015) 1.12
Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia. J Cereb Blood Flow Metab (2010) 1.07
Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death. J Neurotrauma (2010) 1.02
Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. BMC Neurosci (2009) 1.00
Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis. Crit Care (2014) 1.00
Brain tissue oxygen tension monitoring in pediatric severe traumatic brain injury. Part 1: Relationship with outcome. Childs Nerv Syst (2009) 0.98
Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke. Med Gas Res (2011) 0.98
Normobaric oxygen therapy in acute ischemic stroke: A pilot study in Indian patients. Ann Indian Acad Neurol (2010) 0.97
Stability of large diffusion/perfusion mismatch in anterior circulation strokes for 4 or more hours. BMC Neurol (2010) 0.94
Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery. Br J Pharmacol (2007) 0.94
Hyperoxia promotes astrocyte cell death after oxygen and glucose deprivation. Glia (2008) 0.92
Imaging stroke patients with unclear onset times. Neuroimaging Clin N Am (2011) 0.90
Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats. Exp Neurol (2013) 0.90
Hyperoxemia and long-term outcome after traumatic brain injury. Crit Care (2013) 0.89
MR perfusion imaging in acute ischemic stroke. Neuroimaging Clin N Am (2011) 0.89
A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Med Gas Res (2012) 0.88
Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage. Med Gas Res (2011) 0.88
Hyperoxia in intensive care, emergency, and peri-operative medicine: Dr. Jekyll or Mr. Hyde? A 2015 update. Ann Intensive Care (2015) 0.88
Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2*-weighted MRI in a rat stroke model. J Cereb Blood Flow Metab (2011) 0.88
Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia. Exp Neurol (2012) 0.87
Normobaric hyperoxia delays and attenuates early nitric oxide production in focal cerebral ischemic rats. Brain Res (2010) 0.87
Clinical review: Imaging in ischaemic stroke--implications for acute management. Crit Care (2007) 0.86
Bench-to-bedside review: the effects of hyperoxia during critical illness. Crit Care (2015) 0.86
Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model. Exp Neurol (2015) 0.86
Non-pharmaceutical therapies for stroke: mechanisms and clinical implications. Prog Neurobiol (2014) 0.86
Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke. Med Gas Res (2013) 0.85
Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke. J Cereb Blood Flow Metab (2012) 0.85
Where will the next generation of stroke treatments come from? PLoS Med (2010) 0.84
Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive models. Med Gas Res (2012) 0.83
Supplementary oxygen for nonhypoxemic patients: O2 much of a good thing? Crit Care (2011) 0.83
Protection against focal ischemic injury to the brain by trans-sodium crocetinate. Laboratory investigation. J Neurosurg (2010) 0.83
The SOS pilot study: a RCT of routine oxygen supplementation early after acute stroke--effect on recovery of neurological function at one week. PLoS One (2011) 0.82
The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months. PLoS One (2013) 0.82
The physiology behind direct brain oxygen monitors and practical aspects of their use. Childs Nerv Syst (2010) 0.81
Inhibition of gp91(phox) contributes towards normobaric hyperoxia afforded neuroprotection in focal cerebral ischemia. Brain Res (2010) 0.80
Hyperoxia: a review of the risks and benefits in adult cardiac surgery. J Extra Corpor Technol (2012) 0.80
Advances in emerging nondrug therapies for acute stroke 2007. Stroke (2008) 0.80
Vascular Dysfunction in Brain Hemorrhage: Translational Pathways to Developing New Treatments from Old Targets. J Neurol Neurophysiol (2011) 0.79
Brain tissue oxygen tension monitoring in pediatric severe traumatic brain injury. Part 2: Relationship with clinical, physiological, and treatment factors. Childs Nerv Syst (2009) 0.79
Hypoxia after stroke: a review of experimental and clinical evidence. Exp Transl Stroke Med (2016) 0.79
Effects of Hyperoxia on Oxygen-Related Inflammation with a Focus on Obesity. Oxid Med Cell Longev (2015) 0.79
Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective. Med Gas Res (2016) 0.79
Normobaric hyperoxia slows blood-brain barrier damage and expands the therapeutic time window for tissue-type plasminogen activator treatment in cerebral ischemia. Stroke (2015) 0.78
Endothelial dysfunction abrogates the efficacy of normobaric hyperoxia in stroke. J Neurosci (2014) 0.78
Power and sample size calculations for the Wilcoxon-Mann-Whitney test in the presence of death-censored observations. Stat Med (2014) 0.76
Effects of stroke severity and treatment duration in normobaric hyperoxia treatment of ischemic stroke. Brain Res (2016) 0.76
Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries. BMC Pulm Med (2017) 0.75
Supplemental oxygen delivery to suspected stroke patients in pre hospital and emergency department settings. Med Gas Res (2014) 0.75
Differentiation of the Infarct Core from Ischemic Penumbra within the First 4.5 Hours, Using Diffusion Tensor Imaging-Derived Metrics: A Rat Model. Korean J Radiol (2017) 0.75
The effect of a therapeutic regimen of Traditional Chinese Medicine rehabilitation for post-stroke cognitive impairment: study protocol for a randomized controlled trial. Trials (2015) 0.75
Acute Stroke: Current Evidence-based Recommendations for Prehospital Care. West J Emerg Med (2016) 0.75
Correcting for Brain Swelling's Effects on Infarct Volume Calculation After Middle Cerebral Artery Occlusion in Rats. Transl Stroke Res (2015) 0.75
What are high-flow and low-flow oxygen delivery systems? Stroke (2005) 0.75
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 24.26
Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol (2010) 14.79
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell (2007) 12.52
Angiogenesis in brain tumours. Nat Rev Neurosci (2007) 6.82
Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke (2009) 6.79
The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14
Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med (2006) 5.10
Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study. Cereb Cortex (2004) 4.50
Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol (2009) 4.17
Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N Engl J Med (2009) 3.85
Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med (2008) 3.83
Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J Clin Oncol (2013) 3.81
Brain morphometry with multiecho MPRAGE. Neuroimage (2008) 3.61
Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix. Magn Reson Med (2003) 3.44
Subarachnoid hemorrhage without evident cause on initial angiography studies: diagnostic yield of subsequent angiography and other neuroimaging tests. J Neurosurg (2003) 3.43
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol (2010) 3.43
DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol (2011) 3.18
Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med (2003) 3.10
An evidence-based causative classification system for acute ischemic stroke. Ann Neurol (2005) 3.09
Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol (2009) 3.02
Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. AJNR Am J Neuroradiol (2004) 2.78
Case records of the Massachusetts General Hospital. Case 39-2012. A 55-year-old man with alcoholism, recurrent seizures, and agitation. N Engl J Med (2012) 2.74
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 27-2004. A 79-year-old woman with disturbances in gait, cognition, and autonomic function. N Engl J Med (2004) 2.67
Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI. Hippocampus (2009) 2.66
A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke (2007) 2.63
On-line automatic slice positioning for brain MR imaging. Neuroimage (2005) 2.62
Recommendations for imaging of acute ischemic stroke: a scientific statement from the American Heart Association. Stroke (2009) 2.55
Real-time rigid body motion correction and shimming using cloverleaf navigators. Magn Reson Med (2006) 2.50
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-2003. A 58-year-old woman with left-sided weakness and a right frontal brain mass. N Engl J Med (2003) 2.39
Disconnection of the ascending arousal system in traumatic coma. J Neuropathol Exp Neurol (2013) 2.38
Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods (2010) 2.37
Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke. Stroke (2008) 2.34
Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke (2002) 2.30
Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke (2006) 2.27
Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke (2008) 2.25
Relationship between hyperglycemia and symptomatic vasospasm after subarachnoid hemorrhage. Crit Care Med (2005) 2.24
Clinical features and outcomes of carotid artery stenting by clinical expert consensus criteria: a report from the CARE registry. Catheter Cardiovasc Interv (2010) 2.21
Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR Am J Neuroradiol (2004) 2.21
Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology (2012) 2.19
Magnetic resonance imaging as a potential surrogate for relapses in multiple sclerosis: a meta-analytic approach. Ann Neurol (2009) 2.18
Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype. J Nucl Med (2010) 2.15
Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke (2004) 2.13
Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci Transl Med (2012) 2.12
Case records of the Massachusetts General Hospital. Case 11-2007. A 59-year-old man with neck pain, weakness in the arms, and cranial-nerve palsies. N Engl J Med (2007) 2.11
Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke (2008) 2.10
Correction for artifacts induced by B(0) and B(1) field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging. Magn Reson Med (2007) 2.09
Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study. AIDS (2007) 2.09
Visual word processing and experiential origins of functional selectivity in human extrastriate cortex. Proc Natl Acad Sci U S A (2007) 2.06
Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci U S A (2008) 2.06
Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci (2003) 2.05
Poor outcomes in patients who do not receive intravenous tissue plasminogen activator because of mild or improving ischemic stroke. Stroke (2005) 2.03
Case records of the Massachusetts General Hospital. Case 11-2008. A 45-year-old man with changes in mental status after liver transplantation. N Engl J Med (2008) 2.02
Case records of the Massachusetts General Hospital. Case 18-2012. A 35-year-old man with neck pain, hoarseness, and dysphagia. N Engl J Med (2012) 2.02
Investigation of optimizing and translating pH-sensitive pulsed-chemical exchange saturation transfer (CEST) imaging to a 3T clinical scanner. Magn Reson Med (2008) 2.01
Case records of the Massachusetts General Hospital. Case 8-2014. A 29-year-old man with headache, vomiting, and diplopia. N Engl J Med (2014) 2.01
Collateral vessels on CT angiography predict outcome in acute ischemic stroke. Stroke (2009) 1.94
Cortical spreading depression activates and upregulates MMP-9. J Clin Invest (2004) 1.93
Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain (2007) 1.92
Cell-cell signaling in the neurovascular unit. Neurochem Res (2007) 1.92
Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. J Neurosci (2008) 1.89
The spot sign score in primary intracerebral hemorrhage identifies patients at highest risk of in-hospital mortality and poor outcome among survivors. Stroke (2009) 1.89
Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke (2008) 1.88
CT and conventional and diffusion-weighted MR imaging in acute stroke: study in 691 patients at presentation to the emergency department. Radiology (2002) 1.85
Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. J Neurosci (2006) 1.85
A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study. Am J Hum Genet (2003) 1.85
Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J (2009) 1.82
The neurotoxicity of tissue plasminogen activator? J Cereb Blood Flow Metab (2004) 1.80
Multiphasic roles for matrix metalloproteinases after stroke. Curr Opin Pharmacol (2008) 1.79
Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke (2005) 1.77
Imaging angiogenesis: applications and potential for drug development. J Natl Cancer Inst (2005) 1.76
The Carotid Artery Revascularization and Endarterectomy (CARE) registry: objectives, design, and implications. Catheter Cardiovasc Interv (2008) 1.75