ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

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Published in Cancer Cell on March 01, 2005

Authors

Kiranmai Gumireddy1, M V Ramana Reddy, Stephen C Cosenza, R Boominathan, R Boomi Nathan, Stacey J Baker, Nabisa Papathi, Jiandong Jiang, James Holland, E Premkumar Reddy

Author Affiliations

1: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 N. Broad Street, Philadelphia, Pennsylvania 19140, USA.

Associated clinical trials:

Effect of 2-h Infusion of ON 01910.Na in Ovarian Cancer Patients | NCT00856791

A Pilot Study of the Safety and Activity of Escalating Doses of ON 01910.Na in Patients With Relapsed Mantle Cell Lymphoma, Multiple Myeloma, Chronic Lymphocytic Leukemia, and Related Lymphoid Malignancies | NCT00861510

Safety of ON 01910.Na and Irinotecan or ON 01910.Na and Oxaliplatin in Patients With Hepatoma | NCT00861783

Safety Study of ON 01910.Na in Combination With Irinotecan or Oxaliplatin | NCT00861328

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