Published in Nat Struct Mol Biol on March 13, 2005
Bacterial programmed cell death and multicellular behavior in bacteria. PLoS Genet (2006) 3.56
Bacterial persistence by RNA endonucleases. Proc Natl Acad Sci U S A (2011) 3.52
Regulation of growth and death in Escherichia coli by toxin-antitoxin systems. Nat Rev Microbiol (2011) 2.49
HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. J Bacteriol (2008) 2.26
An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Mol Microbiol (2007) 2.11
The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE. Cell (2009) 2.01
Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Mol Microbiol (2009) 1.76
MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli. J Biol Chem (2009) 1.74
Toxin-antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococci. Proc Natl Acad Sci U S A (2006) 1.68
Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog (2009) 1.65
Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation. J Biol Chem (2008) 1.62
prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. J Mol Biol (2007) 1.57
Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem (2008) 1.49
Characterization of MazFSa, an endoribonuclease from Staphylococcus aureus. J Bacteriol (2007) 1.47
The inhibitory mechanism of protein synthesis by YoeB, an Escherichia coli toxin. J Biol Chem (2009) 1.47
Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites. J Biol Chem (2009) 1.44
Expression of the Streptococcus pneumoniae yoeB chromosomal toxin gene causes cell death in the model plant Arabidopsis thaliana. BMC Biotechnol (2015) 1.41
Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site. J Biol Chem (2009) 1.35
RelB and RelE of Escherichia coli form a tight complex that represses transcription via the ribbon-helix-helix motif in RelB. J Mol Biol (2009) 1.35
Staphylococcus aureus MazF specifically cleaves a pentad sequence, UACAU, which is unusually abundant in the mRNA for pathogenic adhesive factor SraP. J Bacteriol (2009) 1.31
Kluyveromyces lactis gamma-toxin, a ribonuclease that recognizes the anticodon stem loop of tRNA. Nucleic Acids Res (2007) 1.18
Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages. J Bacteriol (2008) 1.17
Artificial activation of toxin-antitoxin systems as an antibacterial strategy. Trends Microbiol (2012) 1.15
The solution structure of ParD, the antidote of the ParDE toxin antitoxin module, provides the structural basis for DNA and toxin binding. Protein Sci (2007) 1.14
Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation. J Biol Chem (2010) 1.11
Bacterial toxin-antitoxin systems: Translation inhibitors everywhere. Mob Genet Elements (2011) 1.11
The bacterial toxin RelE induces specific mRNA cleavage in the A site of the eukaryote ribosome. RNA (2007) 1.10
Conditional cooperativity in toxin-antitoxin regulation prevents random toxin activation and promotes fast translational recovery. Nucleic Acids Res (2012) 1.06
The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site. Protein Sci (2012) 1.05
The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates. PLoS One (2010) 1.00
RatA (YfjG), an Escherichia coli toxin, inhibits 70S ribosome association to block translation initiation. Mol Microbiol (2011) 0.99
Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis. Nucleic Acids Res (2011) 0.98
Influence of operator site geometry on transcriptional control by the YefM-YoeB toxin-antitoxin complex. J Bacteriol (2008) 0.96
Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. PLoS One (2012) 0.96
Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many. Microbiol Mol Biol Rev (2012) 0.94
The ζ toxin induces a set of protective responses and dormancy. PLoS One (2012) 0.91
Functional identification of toxin-antitoxin molecules from Helicobacter pylori 26695 and structural elucidation of the molecular interactions. J Biol Chem (2010) 0.89
Bacterial toxin RelE: a highly efficient ribonuclease with exquisite substrate specificity using atypical catalytic residues. Biochemistry (2013) 0.89
Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex. J Biol Chem (2013) 0.87
Solution structure and membrane binding of the toxin fst of the par addiction module. Biochemistry (2010) 0.86
One cannot rule them all: Are bacterial toxins-antitoxins druggable? FEMS Microbiol Rev (2015) 0.85
Post-transcriptional control by bacteriophage T4: mRNA decay and inhibition of translation initiation. Virol J (2010) 0.85
Keeping the Wolves at Bay: Antitoxins of Prokaryotic Type II Toxin-Antitoxin Systems. Front Mol Biosci (2016) 0.85
Defining the mRNA recognition signature of a bacterial toxin protein. Proc Natl Acad Sci U S A (2015) 0.85
The structure and interactions of SpoIISA and SpoIISB, a toxin-antitoxin system in Bacillus subtilis. J Biol Chem (2010) 0.84
Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ. J Biol Chem (2014) 0.83
Crystallization of Doc and the Phd-Doc toxin-antitoxin complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.83
Structural and functional characterization of Escherichia coli toxin-antitoxin complex DinJ-YafQ. J Biol Chem (2014) 0.83
Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon. Front Microbiol (2014) 0.83
RelBE or not to be. Nat Struct Mol Biol (2005) 0.81
Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes. Structure (2013) 0.81
Transition State Charge Stabilization and Acid-Base Catalysis of mRNA Cleavage by the Endoribonuclease RelE. Biochemistry (2015) 0.80
Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.80
Molecular basis of ribosome recognition and mRNA hydrolysis by the E. coli YafQ toxin. Nucleic Acids Res (2015) 0.80
Structure, Biology, and Therapeutic Application of Toxin-Antitoxin Systems in Pathogenic Bacteria. Toxins (Basel) (2016) 0.78
Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in Helicobacter pylori and structural elucidation of their protein-protein interaction. J Biol Chem (2013) 0.78
The ClpXP protease is responsible for the degradation of the Epsilon antidote to the Zeta toxin of the streptococcal pSM19035 plasmid. J Biol Chem (2014) 0.78
Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.78
When Competing Viruses Unify: Evolution, Conservation, and Plasticity of Genetic Identities. J Mol Evol (2015) 0.77
Structural analysis of hypothetical proteins from Helicobacter pylori: an approach to estimate functions of unknown or hypothetical proteins. Int J Mol Sci (2012) 0.77
Identification and characterization of a HEPN-MNT family type II toxin-antitoxin in Shewanella oneidensis. Microb Biotechnol (2015) 0.76
Novel Escherichia coli RF1 mutants with decreased translation termination activity and increased sensitivity to the cytotoxic effect of the bacterial toxins Kid and RelE. Mol Microbiol (2008) 0.76
Function inferences from a molecular structural model of bacterial ParE toxin. Bioinformation (2010) 0.75
Crystallization and preliminary X-ray analysis of two variants of the Escherichia coli O157 ParE2-PaaA2 toxin-antitoxin complex. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a β-strand sliding mechanism. Nucleic Acids Res (2017) 0.75
Purification and crystallization of Phd, the antitoxin of the phd/doc operon. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process. Proc Natl Acad Sci U S A (2003) 2.37
High-density electron anions in a nanoporous single crystal: [Ca24Al28O64]4+(4e-). Science (2003) 2.30
Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif-like domain. Protein Sci (2006) 2.29
A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem (2003) 1.98
Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase. Nature (2003) 1.80
Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis. Cardiovasc Res (2010) 1.69
Ammonia channel couples glutaminase with transamidase reactions in GatCAB. Science (2006) 1.67
Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability. Mol Biol Cell (2007) 1.61
Flash-cooling of macromolecular crystals in a capillary to overcome increased mosaicity. Acta Crystallogr D Biol Crystallogr (2003) 1.53
DGGE method for analyzing 16S rDNA of methanogenic archaeal community in paddy field soil. FEMS Microbiol Lett (2004) 1.52
Itokawa dust particles: a direct link between S-type asteroids and ordinary chondrites. Science (2011) 1.51
Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma. J Biochem (2007) 1.51
The structure of rat liver vault at 3.5 angstrom resolution. Science (2009) 1.50
SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression. Cancer Res (2012) 1.50
Chinese herbal medicine for osteoporosis: a systematic review of randomized controlled trails. Evid Based Complement Alternat Med (2013) 1.49
The crystal structure of exonuclease RecJ bound to Mn2+ ion suggests how its characteristic motifs are involved in exonuclease activity. Proc Natl Acad Sci U S A (2002) 1.44
Crystal structure of the octameric pore of staphylococcal γ-hemolysin reveals the β-barrel pore formation mechanism by two components. Proc Natl Acad Sci U S A (2011) 1.43
LAFIRE: software for automating the refinement process of protein-structure analysis. Acta Crystallogr D Biol Crystallogr (2006) 1.43
Measurement of vascular wall attenuation: comparison of CT angiography using model-based iterative reconstruction with standard filtered back-projection algorithm CT in vitro. Eur J Radiol (2012) 1.41
Comparison of the incidence of late stent thrombosis after implantation of different drug-eluting stents in the real world coronary heart disease patients: three-year follow-up results. Chin Med J (Engl) (2010) 1.40
Two-year clinical outcome after successful implantation of drug-eluting and bare metal stents in diabetic patients: results from a real-world single center registry. Chin Med J (Engl) (2009) 1.39
Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int J Oncol (2007) 1.35
Crystal structure of an RtcB homolog protein (PH1602-extein protein) from Pyrococcus horikoshii reveals a novel fold. Proteins (2006) 1.31
Radiation doses to structures within and adjacent to the larynx are correlated with long-term diet- and speech-related quality of life. Int J Radiat Oncol Biol Phys (2007) 1.29
Multilocus genotyping and molecular phylogenetics resolve a novel head blight pathogen within the Fusarium graminearum species complex from Ethiopia. Fungal Genet Biol (2008) 1.25
Roll: a new algorithm for the detection of protein pockets and cavities with a rolling probe sphere. Bioinformatics (2009) 1.24
Molecular basis of alanine discrimination in editing site. Proc Natl Acad Sci U S A (2005) 1.23
Structural basis for multimeric heme complexation through a specific protein-heme interaction: the case of the third neat domain of IsdH from Staphylococcus aureus. J Biol Chem (2008) 1.22
Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes. Lasers Surg Med (2009) 1.21
Structural reorganization of the bacterial cell-division protein FtsZ from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr (2012) 1.20
Reconstitution of archaeal ribonuclease P from RNA and four protein components. Biochem Biophys Res Commun (2003) 1.19
Enhanced secretion of glucagon-like peptide 1 by biguanide compounds. Biochem Biophys Res Commun (2002) 1.17
Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers. Int J Oncol (2009) 1.17
The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process. J Mol Biol (2002) 1.17
Cellulose complementing factor (Ccp) is a new member of the cellulose synthase complex (terminal complex) in Acetobacter xylinum. J Biosci Bioeng (2013) 1.15
ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner. Biochem Biophys Res Commun (2008) 1.14
Propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis (2005) 1.14
Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH. Proc Natl Acad Sci U S A (2012) 1.14
Crystal structure of chondroitin polymerase from Escherichia coli K4. Biochem Biophys Res Commun (2008) 1.13
Structural and functional analysis of a glycoside hydrolase family 97 enzyme from Bacteroides thetaiotaomicron. J Biol Chem (2008) 1.12
Structure of bacterial cellulose synthase subunit D octamer with four inner passageways. Proc Natl Acad Sci U S A (2010) 1.11
Xenopus laevis macrophage migration inhibitory factor is essential for axis formation and neural development. J Biol Chem (2004) 1.11
Crystal structure of the alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. at 1.2 A resolution. J Mol Biol (2004) 1.10
Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice. J Nutr (2005) 1.10
The current status of intensity-modulated radiation therapy in the treatment of nasopharyngeal carcinoma. Cancer Treat Rev (2007) 1.10
Current status and future prospects for satraplatin, an oral platinum analogue. Clin Cancer Res (2008) 1.10
Natural dissociation of olivine to (Mg,Fe)SiO3 perovskite and magnesiowustite in a shocked Martian meteorite. Proc Natl Acad Sci U S A (2011) 1.09
Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring. Tumour Biol (2013) 1.08
Long-term quality of life for surgical and nonsurgical treatment of head and neck cancer. Arch Otolaryngol Head Neck Surg (2005) 1.08
Phytotoxic effects of trichothecenes on the growth and morphology of Arabidopsis thaliana. J Exp Bot (2007) 1.08
Structural basis for translation factor recruitment to the eukaryotic/archaeal ribosomes. J Biol Chem (2009) 1.07
Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis. Biochem Biophys Res Commun (2006) 1.07
The 1.48 A resolution crystal structure of the homotetrameric cytidine deaminase from mouse. Biochemistry (2006) 1.06
Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors. Acta Oncol (2012) 1.06
Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase. J Biol Chem (2007) 1.06
Semi-automatic protein crystallization system that allows in situ observation of X-ray diffraction from crystals in the drop. Acta Crystallogr D Biol Crystallogr (2002) 1.05
Structure of archaeal translational initiation factor 2 betagamma-GDP reveals significant conformational change of the beta-subunit and switch 1 region. Proc Natl Acad Sci U S A (2006) 1.04
Transradial versus transfemoral method of percutaneous coronary revascularization for unprotected left main coronary artery disease: comparison of procedural and late-term outcomes. JACC Cardiovasc Interv (2010) 1.04
Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure. Biochim Biophys Acta (2011) 1.04
Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists. Biochem Biophys Res Commun (2002) 1.03
Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme. J Mol Biol (2006) 1.03
The structure of alanyl-tRNA synthetase with editing domain. Proc Natl Acad Sci U S A (2009) 1.03
Structure determination of a novel protein by sulfur SAD using chromium radiation in combination with a new crystal-mounting method. Acta Crystallogr D Biol Crystallogr (2005) 1.03
Theoretical ELNES using one-particle and multi-particle calculations. Micron (2010) 1.03
Ulinastatin improves pulmonary function in severe burn-induced acute lung injury by attenuating inflammatory response. J Trauma (2011) 1.03
Specific molecular markers in hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int (2007) 1.02
Crystal structure of hypothetical protein PH0642 from Pyrococcus horikoshii at 1.6A resolution. Proteins (2004) 1.02
Meningioma associated with intraosseous lipoma. Clin Neurol Neurosurg (2003) 1.02
Crystal structures of the multidrug binding repressor Corynebacteriumglutamicum CgmR in complex with inducers and with an operator. J Mol Biol (2010) 1.02
Structure of the catalytic nucleotide-binding subunit A of A-type ATP synthase from Pyrococcus horikoshii reveals a novel domain related to the peripheral stalk. Acta Crystallogr D Biol Crystallogr (2006) 1.01
Fusarium phytotoxin trichothecenes have an elicitor-like activity in Arabidopsis thaliana, but the activity differed significantly among their molecular species. Mol Plant Microbe Interact (2006) 1.01
Two distinct regions in Staphylococcus aureus GatCAB guarantee accurate tRNA recognition. Nucleic Acids Res (2009) 1.00
An assay system for in vitro detection of permeability in human "endothelium". Methods Enzymol (2008) 1.00
The chondroitin polymerase K4CP and the molecular mechanism of selective bindings of donor substrates to two active sites. J Biol Chem (2008) 1.00
AtNFXL1, an Arabidopsis homologue of the human transcription factor NF-X1, functions as a negative regulator of the trichothecene phytotoxin-induced defense response. Plant J (2007) 1.00
Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide. Cancer Sci (2009) 1.00