Published in Annu Rev Immunol on January 01, 2005
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell (2009) 11.52
Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10
Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest (2007) 5.17
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med (2009) 4.03
Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest (2008) 3.90
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med (2011) 3.63
Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci (2006) 2.85
Prostate cancer and inflammation: the evidence. Histopathology (2012) 2.60
Targeting the interleukin-6/Jak/stat pathway in human malignancies. J Clin Oncol (2012) 2.46
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med (2009) 2.38
Development and characterization of IL-21-producing CD4+ T cells. J Exp Med (2008) 2.34
Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol (2009) 2.32
Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. Breast Cancer Res (2007) 2.32
IL-6 involvement in epithelial cancers. J Clin Invest (2007) 2.29
TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc Natl Acad Sci U S A (2007) 2.22
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci (2012) 2.15
Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science (2011) 2.15
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3. J Exp Med (2009) 2.11
The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood (2008) 2.05
Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells (2009) 1.97
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. Cancer Microenviron (2010) 1.96
Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome. Proc Natl Acad Sci U S A (2011) 1.80
Th17 cells: from precursors to players in inflammation and infection. Int Immunol (2009) 1.77
IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol (2008) 1.66
IL-6 expression regulates tumorigenicity and correlates with prognosis in bladder cancer. PLoS One (2013) 1.62
Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol (2012) 1.61
Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients. Clin Exp Immunol (2013) 1.55
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes. Curr Opin Immunol (2012) 1.51
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc Natl Acad Sci U S A (2010) 1.50
Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta (2010) 1.50
Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis. Curr Opin Allergy Clin Immunol (2012) 1.43
Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification. Anal Chem (2010) 1.42
Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proc Natl Acad Sci U S A (2006) 1.39
Averting inflammation by targeting the cytokine environment. Nat Rev Drug Discov (2010) 1.36
miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB. J Biol Chem (2011) 1.29
Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology (2006) 1.28
Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases. Int J Biol Sci (2012) 1.27
IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol (2014) 1.27
Paracrinicity: the story of 30 years of cellular pituitary crosstalk. J Neuroendocrinol (2008) 1.24
STAT3 negatively regulates thyroid tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.23
Systematic review of tocilizumab for rheumatoid arthritis: a new biologic agent targeting the interleukin-6 receptor. Clin Ther (2012) 1.23
S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling. Endocrinology (2008) 1.23
The Th1:th2 dichotomy of pregnancy and preterm labour. Mediators Inflamm (2012) 1.22
Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells. PLoS Pathog (2008) 1.21
p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elements. J Biol Chem (2007) 1.21
The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. J Gastroenterol (2012) 1.20
Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling. Proc Natl Acad Sci U S A (2009) 1.20
Immunity to infection in IL-17-deficient mice and humans. Eur J Immunol (2012) 1.18
The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats. Br J Pharmacol (2011) 1.18
The role of miR-206 in the epidermal growth factor (EGF) induced repression of estrogen receptor-alpha (ERalpha) signaling and a luminal phenotype in MCF-7 breast cancer cells. Mol Endocrinol (2009) 1.17
IL-6 is required for airway mucus production induced by inhaled fungal allergens. J Immunol (2009) 1.17
Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation. Breast Cancer Res (2010) 1.17
Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals. Blood (2009) 1.17
Association of interleukin-6 signalling with the muscle stem cell response following muscle-lengthening contractions in humans. PLoS One (2009) 1.16
Inflammatory cytokines in systemic lupus erythematosus. J Biomed Biotechnol (2011) 1.16
Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics. Arthritis Res Ther (2014) 1.15
Population differences in proinflammatory biology: Japanese have healthier profiles than Americans. Brain Behav Immun (2010) 1.14
Negative emotions predict elevated interleukin-6 in the United States but not in Japan. Brain Behav Immun (2013) 1.13
Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain. Int J Radiat Biol (2010) 1.12
Localized immunosuppressive environment in the foreign body response to implanted biomaterials. Am J Pathol (2009) 1.12
Tristetraprolin regulates interleukin-6, which is correlated with tumor progression in patients with head and neck squamous cell carcinoma. Cancer (2011) 1.12
Direct regulation of interleukin-6 expression by Notch signaling in macrophages. Cell Mol Immunol (2011) 1.10
Quantitative in vivo cytokine analysis at synthetic biomaterial implant sites. J Biomed Mater Res A (2009) 1.10
Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: results from a retrospective study (REACTION study). Mod Rheumatol (2010) 1.08
Interleukin-6 (IL-6) and IL-17 synergistically promote viral persistence by inhibiting cellular apoptosis and cytotoxic T cell function. J Virol (2014) 1.08
Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation. J Pathol (2011) 1.08
Innate immunity in inflammatory bowel disease: a disease hypothesis. J Pathol (2008) 1.08
Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status. Arthritis Rheum (2007) 1.07
IL-6 and MYC collaborate in plasma cell tumor formation in mice. Blood (2009) 1.07
Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease. Respir Res (2013) 1.06
Cytokines in systemic lupus erythematosus. Curr Mol Med (2009) 1.03
Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Proc Natl Acad Sci U S A (2013) 1.02
An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification. Blood (2011) 1.02
Early activation of rat skeletal muscle IL-6/STAT1/STAT3 dependent gene expression in resistance exercise linked to hypertrophy. PLoS One (2013) 1.01
GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment. J Biol Chem (2011) 1.01
Chronic exposure to the cytolethal distending toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response. Cell Microbiol (2012) 1.00
Interleukin 6 and rheumatoid arthritis. Biomed Res Int (2014) 1.00
Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study. Br J Clin Pharmacol (2011) 0.99
Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway. Stem Cells (2015) 0.99
The varying faces of IL-6: From cardiac protection to cardiac failure. Cytokine (2015) 0.98
Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis. PLoS One (2012) 0.98
Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future. Autoimmunity (2010) 0.98
T Cell Migration in Rheumatoid Arthritis. Front Immunol (2015) 0.98
CD4 T cells: Balancing the coming and going of autoimmune-mediated inflammation in the CNS. Brain Behav Immun (2008) 0.97
Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J Biol Chem (2014) 0.97
Involvement of interleukin-6 and androgen receptor signaling in pancreatic cancer. Genes Cancer (2010) 0.97
Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction. Am J Physiol Cell Physiol (2013) 0.97
Tocilizumab in the treatment of rheumatoid arthritis and beyond. Drug Des Devel Ther (2014) 0.97
Satellite cells in human skeletal muscle plasticity. Front Physiol (2015) 0.96
Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS. PLoS Pathog (2012) 0.96
Aberrant signaling pathways in glioma. Cancers (Basel) (2011) 0.96
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. J Clin Invest (2013) 0.96
Starvation alters the liver transcriptome of the innate immune response in Atlantic salmon (Salmo salar). BMC Genomics (2010) 0.95
IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood (2010) 0.95
Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer. Prostate Cancer (2013) 0.94