Published in Annu Rev Immunol on January 01, 2005
Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability. Cancer Res (2006) 3.52
The known unknowns of antigen processing and presentation. Nat Rev Immunol (2008) 2.85
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature (2017) 2.43
Mechanisms for T cell receptor triggering. Nat Rev Immunol (2010) 2.30
Protein-protein interactions in the membrane: sequence, structural, and biological motifs. Structure (2008) 1.75
High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Sci STKE (2007) 1.51
The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol (2010) 1.44
Fast on-rates allow short dwell time ligands to activate T cells. Proc Natl Acad Sci U S A (2010) 1.43
Deregulated inflammasome signaling in disease. Immunol Rev (2011) 1.39
Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. Cold Spring Harb Perspect Biol (2010) 1.16
A unique T cell receptor discovered in marsupials. Proc Natl Acad Sci U S A (2007) 1.14
Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS One (2010) 1.08
Biochemical visualization of cell surface molecular clustering in living cells. Proc Natl Acad Sci U S A (2008) 1.08
Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domestica. BMC Genomics (2008) 1.07
HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling. PLoS One (2007) 1.02
Engineering higher affinity T cell receptors using a T cell display system. J Immunol Methods (2008) 1.00
Regulation from within: the cytoskeleton in transmembrane signaling. Trends Cell Biol (2012) 0.99
Upregulated TCRζ enhances interleukin-2 production in T-cells from patients with CML. DNA Cell Biol (2012) 0.99
TCR Signaling Emerges from the Sum of Many Parts. Front Immunol (2012) 0.99
Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia. J Hematol Oncol (2012) 0.97
Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization. J Immunol (2008) 0.93
Molecular immunology lessons from therapeutic T-cell receptor gene transfer. Immunology (2010) 0.91
Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferations. Haematologica (2010) 0.91
Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. J Immunol (2011) 0.90
T cell antigen recognition at the cell membrane. Mol Immunol (2012) 0.90
A view into the blind spot: solution NMR provides new insights into signal transduction across the lipid bilayer. Structure (2010) 0.89
Stoichiometry of the murine gammadelta T cell receptor. J Exp Med (2006) 0.89
The signal peptide of the IgE receptor alpha-chain prevents surface expression of an immunoreceptor tyrosine-based activation motif-free receptor pool. J Biol Chem (2010) 0.89
Enhancement of the TCRζ expression, polyclonal expansion, and activation of t cells from patients with acute myeloid leukemia after IL-2, IL-7, and IL-12 induction. DNA Cell Biol (2015) 0.88
A TIRF microscopy technique for real-time, simultaneous imaging of the TCR and its associated signaling proteins. J Vis Exp (2012) 0.87
The first transmembrane region of the beta-chain stabilizes the tetrameric Fc epsilon RI complex. Mol Immunol (2009) 0.87
T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements. J Biol Chem (2012) 0.87
TCR mu recombination and transcription relative to the conventional TCR during postnatal development in opossums. J Immunol (2009) 0.86
IL-10/TGF-beta-treated dendritic cells, pulsed with insulin, specifically reduce the response to insulin of CD4+ effector/memory T cells from type 1 diabetic individuals. J Clin Immunol (2010) 0.83
Application of adoptive T-cell therapy using tumor antigen-specific T-cell receptor gene transfer for the treatment of human leukemia. J Biomed Biotechnol (2010) 0.81
A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum. Arch Biochem Biophys (2007) 0.80
Newly discovered viral E3 ligase pK3 induces endoplasmic reticulum-associated degradation of class I major histocompatibility proteins and their membrane-bound chaperones. J Biol Chem (2012) 0.79
Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem (2014) 0.79
T-cell antigen receptor (TCR) transmembrane peptides: A new paradigm for the treatment of autoimmune diseases. Cell Adh Migr (2010) 0.79
Quantitative analysis of T cell receptor complex interaction sites using genetically encoded photo-cross-linkers. ACS Chem Biol (2014) 0.77
Inside the microcluster: antigen receptor signalling viewed with molecular imaging tools. Immunology (2011) 0.77
Characteristics of TCRζ, ZAP-70, and FcɛRIγ gene expression in patients with T- and NK/T-cell lymphoma. DNA Cell Biol (2014) 0.77
A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue. Mol Biol Cell (2015) 0.76
Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future. FEBS Lett (2010) 0.75
Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations. J Immunol Res (2017) 0.75
A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane. Proc Natl Acad Sci U S A (2016) 0.75
Domain-swapped T cell receptors improve the safety of TCR gene therapy. Elife (2016) 0.75
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med (2007) 7.73
Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell (2008) 4.00
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J Clin Invest (2003) 3.40
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat Immunol (2005) 3.05
The organizing principle in the formation of the T cell receptor-CD3 complex. Cell (2002) 2.74
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med (2007) 2.64
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2004) 2.34
Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity (2007) 2.23
The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell (2006) 1.95
The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. PLoS Biol (2006) 1.83
Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. J Immunol (2003) 1.71
Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest (2007) 1.58
Common themes in the assembly and architecture of activating immune receptors. Nat Rev Immunol (2007) 1.54
The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proc Natl Acad Sci U S A (2005) 1.54
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity (2012) 1.50
Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol (2009) 1.50
The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol (2010) 1.44
Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol (2005) 1.43
Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med (2012) 1.38
HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide. Nat Immunol (2010) 1.38
Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. Immunity (2005) 1.36
A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC. J Exp Med (2011) 1.34
Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Mol Immunol (2004) 1.30
Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A (2008) 1.30
Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum. EMBO J (2004) 1.28
Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol (2005) 1.28
Ex vivo analysis of thymic CD4 T cells in nonobese diabetic mice with tetramers generated from I-A(g7)/class II-associated invariant chain peptide precursors. J Immunol (2003) 1.22
Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection. Cell (2012) 1.21
Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. J Neuroimmunol (2003) 1.16
Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. J Biol Chem (2007) 1.16
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes. J Immunol (2002) 1.14
Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. RNA (2012) 1.13
Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest (2010) 1.13
MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells. PLoS One (2011) 1.12
Small molecules that enhance the catalytic efficiency of HLA-DM. J Immunol (2006) 1.10
An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines (2013) 1.08
Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication. J Immunol (2005) 1.08
Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. J Clin Invest (2004) 1.08
Suppression of autoimmune diabetes by soluble galectin-1. J Immunol (2009) 1.06
A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol (2004) 1.05
Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. J Clin Invest (2014) 1.04
Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol (2008) 1.03
Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. EMBO J (2007) 1.03
Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain. J Exp Med (2012) 0.98
B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv Immunol (2008) 0.98
A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. J Biol Chem (2006) 0.97
Unusual features of self-peptide/MHC binding by autoimmune T cell receptors. Immunity (2005) 0.97
The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway. Curr Opin Immunol (2011) 0.95
The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood (2003) 0.94
In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol (2009) 0.93
Prevention of type 1 diabetes by gene therapy. J Clin Invest (2004) 0.91
Response multilayered control of T cell receptor phosphorylation. Cell (2010) 0.89
Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. Lab Chip (2012) 0.89
Mechanisms of peptide repertoire selection by HLA-DM. Trends Immunol (2013) 0.89
Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers. AIDS (2012) 0.88
Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. Br J Haematol (2004) 0.87
Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol (2004) 0.85
Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop. Nat Commun (2013) 0.83
Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. J Immunol (2004) 0.83
Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice. Eur J Immunol (2004) 0.81
Immunomodulation for glioblastoma. Curr Opin Neurol (2017) 0.81
Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display. Protein Eng Des Sel (2011) 0.80
Infectious triggers for inflammatory neurological diseases. Nat Med (2002) 0.79
Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide. J Infect Dis (2007) 0.78
Positively selecting peptides: their job does not end in the thymus. Nat Immunol (2009) 0.76
Cracking the code of human T-cell immunity. Nat Biotechnol (2013) 0.75
Autoimmune diseases have been the focus of intense research efforts. Curr Opin Immunol (2011) 0.75
Erratum: The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection. Nat Immunol (2017) 0.75