Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMID 15777746)

Published in Brain Res on March 10, 2005

Authors

Michael L Selley1

Author Affiliations

1: Angiogen Pharmaceuticals Pty. Ltd., Level 31, ABN AMRO Tower, 88 Phillip Street, Sydney, N.S.W. 2000, Australia. mlselley@angiogen.com.au

Articles citing this

Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease. J Neurosci (2009) 1.27

Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. J Neurochem (2008) 1.24

Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases. Front Neuroendocrinol (2008) 1.23

Statin use and the risk of Parkinson disease. Neurology (2008) 1.10

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases. Arch Neurol (2010) 1.08

Targets for neuroprotection in Parkinson's disease. Biochim Biophys Acta (2008) 1.08

Prospects of statins in Parkinson disease. Neuroscientist (2011) 1.07

Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies. Exp Neurol (2009) 1.04

The neurotoxicity of environmental aluminum is still an issue. Neurotoxicology (2010) 1.01

Statin use and Parkinson's disease in Denmark. Mov Disord (2010) 0.93

Pathogenesis-targeted, disease-modifying therapies in Parkinson disease. Neurotherapeutics (2014) 0.92

The endotoxin-induced neuroinflammation model of Parkinson's disease. Parkinsons Dis (2011) 0.89

Statin use and risk of Parkinson's disease: a meta-analysis of observational studies. J Neurol (2012) 0.88

Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses. PLoS One (2011) 0.87

Molecular mechanisms underlying the effects of statins in the central nervous system. Int J Mol Sci (2014) 0.83

Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice. J Neural Transm (Vienna) (2008) 0.83

Neuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives. Int J Mol Sci (2016) 0.80

PET imaging a MPTP-induced mouse model of Parkinson's disease using the fluoropropyl-dihydrotetrabenazine analog [18F]-DTBZ (AV-133). PLoS One (2012) 0.78

Behavioral interactions of simvastatin and fluoxetine in tests of anxiety and depression. Neuropsychiatr Dis Treat (2012) 0.78

Simvastatin inhibited the apoptosis of PC12 cells induced by 1-methyl-4-phenylpyridinium ion via inhibiting reactive oxygen species production. Cell Mol Neurobiol (2012) 0.78

Statin adherence and the risk of Parkinson's disease: A population-based cohort study. PLoS One (2017) 0.75

Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy. BMC Neurosci (2016) 0.75

The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration. Metab Brain Dis (2017) 0.75