Published in Neurochem Res on February 01, 2005
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell (2010) 2.46
Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons. Mol Neurodegener (2011) 1.14
Human brain myelination and amyloid beta deposition in Alzheimer's disease. Alzheimers Dement (2007) 1.10
A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice. Neurobiol Aging (2007) 1.06
Comparison of amyloid plaque contrast generated by T2-weighted, T2*-weighted, and susceptibility-weighted imaging methods in transgenic mouse models of Alzheimer's disease. Magn Reson Med (2009) 0.92
The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders. Front Pharmacol (2014) 0.91
Iron and mechanisms of neurotoxicity. Int J Alzheimers Dis (2010) 0.91
The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory. Cereb Cortex (2012) 0.90
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease. Acta Neuropathol Commun (2013) 0.88
Regional differences in MRI detection of amyloid plaques in AD transgenic mouse brain. Neuroimage (2010) 0.87
MR microimaging of amyloid plaques in Alzheimer's disease transgenic mice. Eur J Nucl Med Mol Imaging (2008) 0.83
SPION-enhanced magnetic resonance imaging of Alzheimer's disease plaques in AβPP/PS-1 transgenic mouse brain. J Alzheimers Dis (2013) 0.82
Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI. J Alzheimers Dis (2011) 0.80
The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease. NMR Biomed (2014) 0.78
In vivo imaging biomarkers in mouse models of Alzheimer's disease: are we lost in translation or breaking through? Int J Alzheimers Dis (2010) 0.78
Enhanced Histochemical Detection of Iron in Paraffin Sections of Mouse Central Nervous System Tissue: Application in the APP/PS1 Mouse Model of Alzheimer's Disease. ASN Neuro (2016) 0.77
A review of β-amyloid neuroimaging in Alzheimer's disease. Front Neurosci (2014) 0.77
Monoaminergic neuropathology in Alzheimer's disease. Prog Neurobiol (2016) 0.76
New Insights into the Crosstalk between NMDARs and Iron: Implications for Understanding Pathology of Neurological Diseases. Front Mol Neurosci (2017) 0.75
Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci (1998) 4.19
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci U S A (1997) 3.47
The metallobiology of Alzheimer's disease. Trends Neurosci (2003) 2.47
Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron. J Biol Chem (2002) 1.74
A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J Neurosci Res (1992) 1.69
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem (1998) 1.68
The regional distribution and cellular localization of iron in the rat brain. Neuroscience (1984) 1.62
Iron in the brain. Nutr Rev (1993) 1.58
Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology (1995) 1.52
Iron deposits in multiple sclerosis and Alzheimer's disease brains. Brain Res (1997) 1.46
["Diaminobenzidine black" as a new histochemical demonstration of exogenous iron (author's transl)]. Histochemistry (1980) 1.42
In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging. Arch Gen Psychiatry (2000) 1.41
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol Dis (1999) 1.38
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magn Reson Med (2004) 1.37
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice. Brain Res (1999) 1.27
Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med (2004) 1.19
Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system. Neuroscience (2003) 1.14
Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. J Neurosci Res (2003) 1.13
Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins. Peptides (2002) 1.10
Iron and neurodegenerative disorders. Brain Res Bull (2001) 1.08
Oligodendrocytes and myelin sheaths in normal, quaking and shiverer brains are enriched in iron. J Neurosci Res (1991) 1.06
Brain iron metabolism and neurodegenerative disorders. Dev Neurosci (2002) 0.98
Iron: a pathological mediator of Alzheimer disease? Dev Neurosci (2002) 0.98
Comparative techniques for determining cellular iron distribution in brain tissues. Ann Neurol (1992) 0.95
A brief history of brain iron research. J Neurol Sci (2003) 0.92
Redox metals in Alzheimer's disease. Ann N Y Acad Sci (2004) 0.88
Preliminary observations of transverse relaxation rates obtained at 3 tesla from the substantia nigra of adult normal human brain. NMR Biomed (1995) 0.79
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med (2005) 6.47
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell (2010) 5.09
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci (2008) 4.63
Trans-synaptic spread of tau pathology in vivo. PLoS One (2012) 4.53
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron (2004) 4.21
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem (2003) 3.79
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci (2004) 3.59
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron (2006) 3.51
Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy (2005) 3.27
MRI quantification of non-Gaussian water diffusion by kurtosis analysis. NMR Biomed (2010) 3.26
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron (2008) 3.08
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.95
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci (2005) 2.94
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain (2011) 2.76
Origin of negative blood oxygenation level-dependent fMRI signals. J Cereb Blood Flow Metab (2002) 2.34
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet (2010) 2.25
Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron (2003) 2.17
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A (2008) 2.09
Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imaging. NMR Biomed (2006) 2.09
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci (2011) 2.09
Estimation of tensors and tensor-derived measures in diffusional kurtosis imaging. Magn Reson Med (2010) 2.04
Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model. J Neurosci (2010) 2.02
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study. Neuroimage (2008) 1.90
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci (2003) 1.88
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging (2004) 1.88
Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci (2009) 1.83
A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse. J Vis Exp (2008) 1.80
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest (2008) 1.79
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. Am J Pathol (2005) 1.77
Age-related non-Gaussian diffusion patterns in the prefrontal brain. J Magn Reson Imaging (2008) 1.72
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A (2009) 1.72
Neuronal macroautophagy: from development to degeneration. Mol Aspects Med (2006) 1.69
Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction. NMR Biomed (2010) 1.67
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci (2008) 1.65
White matter characterization with diffusional kurtosis imaging. Neuroimage (2011) 1.64
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. J Biol Chem (2003) 1.60
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci (2003) 1.59
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron (2008) 1.59
The phospholipase D1 pathway modulates macroautophagy. Nat Commun (2010) 1.56
Stroke assessment with diffusional kurtosis imaging. Stroke (2012) 1.55
New directions for frontotemporal dementia drug discovery. Alzheimers Dement (2007) 1.53
Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet (2007) 1.53
In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A (2003) 1.52
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry (2010) 1.49
Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model. J Neurosci (2011) 1.41
Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging. Magn Reson Med (2005) 1.41
Diffusion tensor imaging in fixed brain tissue at 7.0 T. NMR Biomed (2003) 1.38
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magn Reson Med (2004) 1.37
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol (2004) 1.36
Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. J Neurosci (2003) 1.36
Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magn Reson Med (2003) 1.35
Estimation of the orientation distribution function from diffusional kurtosis imaging. Magn Reson Med (2008) 1.35
Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. J Neurosci (2012) 1.34
Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. J Neurosci (2006) 1.33
Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments. J Biol Chem (2002) 1.31
Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. J Cell Sci (2006) 1.30
Quantitative MR imaging in Alzheimer disease. Radiology (2006) 1.29
ELISA method for measurement of amyloid-beta levels. Methods Mol Biol (2005) 1.28
Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. Am J Pathol (2008) 1.28
Tissue processing prior to protein analysis and amyloid-beta quantitation. Methods Mol Biol (2005) 1.28
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci (2013) 1.27
In vivo detection of gray and white matter differences in GABA concentration in the human brain. Neuroimage (2006) 1.27
Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiol Aging (2004) 1.27
Monte Carlo study of a two-compartment exchange model of diffusion. NMR Biomed (2010) 1.26
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J Biol Chem (2002) 1.26
Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. Am J Pathol (2004) 1.24
Cholesterol in Alzheimer's disease and tauopathy. Ann N Y Acad Sci (2002) 1.23
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol (2008) 1.22
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem (2007) 1.20
Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J Cell Biol (2002) 1.20
Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PLoS One (2010) 1.20
Statin therapy for Alzheimer's disease: will it work? J Mol Neurosci (2002) 1.19
Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med (2004) 1.19
Functional magnetic resonance imaging of brain activity in the visual oddball task. Brain Res Cogn Brain Res (2002) 1.17
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun (2004) 1.16
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci (2008) 1.15
Magnetic field correlation imaging. Magn Reson Med (2006) 1.15
The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. J Neurochem (2006) 1.14
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. J Neurosci (2008) 1.13
Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol (2002) 1.11
Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain. Magn Reson Med (2009) 1.11
Presurgical connectome and postsurgical seizure control in temporal lobe epilepsy. Neurology (2013) 1.10
Revealing mesoscopic structural universality with diffusion. Proc Natl Acad Sci U S A (2014) 1.10
Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases. Autophagy (2006) 1.09
A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment. Neurobiol Dis (2008) 1.09
The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiol Aging (2005) 1.09
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. Am J Pathol (2004) 1.09