Published in Metabolism on June 01, 2005
Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond) (2012) 4.04
AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res (2010) 2.35
Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J Immunol (2009) 1.83
Molecular mechanism of action of metformin: old or new insights? Diabetologia (2013) 1.71
Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation (2010) 1.58
Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin. Exp Diabetes Res (2012) 1.46
AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function. Clin Exp Pharmacol Physiol (2007) 1.35
Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells. PLoS One (2013) 1.29
Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling. Aging (Albany NY) (2011) 1.01
Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension. Br J Pharmacol (2009) 1.01
Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice. PLoS One (2011) 0.98
AMP-activated protein kinase rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismutase induction in type 1 diabetes. Am J Physiol Endocrinol Metab (2011) 0.97
NADPH Oxidase versus Mitochondria-Derived ROS in Glucose-Induced Apoptosis of Pericytes in Early Diabetic Retinopathy. J Ophthalmol (2010) 0.95
NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys. Oxid Med Cell Longev (2013) 0.95
Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats. Free Radic Biol Med (2010) 0.95
A review of thiazolidinediones and metformin in the treatment of type 2 diabetes with focus on cardiovascular complications. Vasc Health Risk Manag (2007) 0.93
Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation. J Surg Res (2014) 0.93
Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clin Sci (Lond) (2013) 0.92
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med (2015) 0.89
Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. J Sex Med (2013) 0.84
The 5'-AMP-Activated Protein Kinase (AMPK) Is Involved in the Augmentation of Antioxidant Defenses in Cryopreserved Chicken Sperm. PLoS One (2015) 0.82
Oxidative stress and endothelium influenced by metformin in type 2 diabetes mellitus. Eur J Clin Pharmacol (2007) 0.81
The hypoglycemic effect of the kelp on diabetes mellitus model induced by alloxan in rats. Int J Mol Sci (2012) 0.79
Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects. Br J Pharmacol (2014) 0.79
Downregulation of Reactive Oxygen Species in Apoptosis. J Cancer Prev (2016) 0.78
Protective effect of metformin on gentamicin-induced vestibulotoxicity in rat primary cell culture. Clin Exp Otorhinolaryngol (2014) 0.78
Role of Pioglitazone with Metformin or Glimepiride on Oxidative Stress-induced Nuclear Damage and Reproductive Toxicity in Diabetic Rats. Malays J Med Sci (2010) 0.78
Lipid-peroxidation and peroxiredoxin-overoxidation in the erythrocytes of non-insulin-dependent type 2 diabetic men during acute exercise. Eur J Appl Physiol (2011) 0.77
Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy. World J Diabetes (2016) 0.77
Hyperglycemia-Mediated Oxidative Stress Increases Pulmonary Vascular Permeability. Microcirculation (2016) 0.76
Antihypercholesterolemic effect of Cleome arabica L. on high cholesterol diet induced damage in rats. EXCLI J (2015) 0.75
The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats. Oxid Med Cell Longev (2016) 0.75
Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems. Sci Rep (2017) 0.75
Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-mediated Inhibition of Mitochondrial Respiration. Mol Cell Biol (2017) 0.75
The Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications. Diseases (2016) 0.75
High incidence of myocardial ischemia during postpartum hemorrhage. Anesthesiology (2004) 2.16
A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis. J Hepatol (2010) 2.02
Assessment of adrenal function in cirrhotic patients: salivary cortisol should be preferred. J Hepatol (2010) 1.60
Impaired plasma B-type natriuretic peptide clearance in human septic shock. Crit Care Med (2008) 1.59
Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res (2010) 1.53
High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats. Hepatology (2007) 1.50
Modification of the β-Adrenoceptor Stimulation Pathway in Zucker Obese and Obese Diabetic Rat Myocardium. Crit Care Med (2015) 1.42
Leukoencephalopathy with vanishing white matter caused by compound heterozygous mutations in mitochondrial complex I NDUFS1 subunit. Mol Genet Metab (2010) 1.40
Acute pancreatitis in a cohort of 129 patients referred for severe hypertriglyceridemia. Pancreas (2008) 1.31
Impaired glucose tolerance in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler (2010) 1.20
Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and *NO bioavailability: Potential benefits to cardiovascular diseases. Biochimie (2011) 1.20
A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis. Hum Genet (2003) 1.17
Increased serum concentrations of soluble receptor for advanced glycation endproducts in patients with type 1 diabetes. Clin Chem (2005) 1.11
Lipids from oxidized low-density lipoprotein modulate human trophoblast invasion: involvement of nuclear liver X receptors. Endocrinology (2004) 1.08
Mitochondrial complex I deficiency of nuclear origin I. Structural genes. Mol Genet Metab (2011) 1.07
An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. PLoS One (2008) 1.05
Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma. Obes Res (2002) 1.01
Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans. Mol Nutr Food Res (2013) 0.99
Ex vivo effects of high-density lipoprotein exposure on the lipopolysaccharide-induced inflammatory response in patients with severe cirrhosis. Hepatology (2009) 0.99
Severe dilated cardiomyopathy and quadriceps myopathy due to lamin A/C gene mutation: a phenotypic study. Eur J Heart Fail (2005) 0.99
Peroxiredoxin 6 fails to limit phospholipid peroxidation in lung from Cftr-knockout mice subjected to oxidative challenge. PLoS One (2009) 0.97
Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease). Orphanet J Rare Dis (2011) 0.96
Atheroprotective reverse cholesterol transport pathway is defective in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol (2011) 0.95
Description of a large family with autosomal dominant hypercholesterolemia associated with the APOE p.Leu167del mutation. Hum Mutat (2012) 0.94
Rosuvastatin versus pravastatin in dyslipidemic HIV-1-infected patients receiving protease inhibitors: a randomized trial. AIDS (2010) 0.93
Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels. Arterioscler Thromb Vasc Biol (2013) 0.92
Human invasive trophoblasts transformed with simian virus 40 provide a new tool to study the role of PPARgamma in cell invasion process. Carcinogenesis (2003) 0.92
Adrenal response in patients with septic shock of abdominal origin: relationship to survival. Intensive Care Med (2007) 0.91
What are the best reference values for a normal serum alanine transaminase activity (ALT)? Impact on the presumed prevalence of drug induced liver injury (DILI). Regul Toxicol Pharmacol (2011) 0.91
Benefits and side effects of different vegetable oil vectors on apoptosis, oxidative stress, and P2X7 cell death receptor activation. Invest Ophthalmol Vis Sci (2007) 0.90
PPARgamma and early human placental development. Curr Med Chem (2008) 0.90
Simple spectrophotometric assessment of the trans-/cis-resveratrol ratio in aqueous solutions. Anal Chim Acta (2008) 0.90
Elevated CETP activity improves plasma cholesterol efflux capacity from human macrophages in women. Arterioscler Thromb Vasc Biol (2012) 0.89
Protective effect of post-ischemic treatment with trans-resveratrol on cytokine production and neutrophil recruitment by rat liver. Biochimie (2009) 0.89
Modulation of indoleamine-2,3-dioxygenase expression and activity by HIV-1 in human macrophages. Fundam Clin Pharmacol (2009) 0.89
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia. Atherosclerosis (2012) 0.88
Lewis-Sumner syndrome and Tangier disease. Arch Neurol (2008) 0.88
Modification of LDL with human secretory phospholipase A(2) or sphingomyelinase promotes its arachidonic acid-releasing propensity. J Lipid Res (2004) 0.87
Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Anal Biochem (2009) 0.87
Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: the positive effect of long-term aspirin treatment. Mol Genet Metab (2011) 0.86
Oxidative stress implication after prolonged storage donor heart with blood versus crystalloid cardioplegia and reperfusion versus static storage. J Surg Res (2009) 0.86
Impairment of thioredoxin reductase activity by oxidative stress in human rheumatoid synoviocytes. Free Radic Res (2007) 0.86
Fourteen-year prospective follow-up study of positive and negative symptoms in chronic schizophrenic patients dying from suicide compared to other causes of death. Psychopathology (2009) 0.86
Mitochondrial complex I deficiency of nuclear origin II. Non-structural genes. Mol Genet Metab (2011) 0.85
Reference values for serum S-100B protein depend on the race of individuals. Clin Chem (2003) 0.84
Interest and limits of glomerular filtration rate (GFR) estimation with formulae using creatinine or cystatin C in the malnourished elderly population. Arch Gerontol Geriatr (2009) 0.84
trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion. Biochimie (2010) 0.84
Elevated serum levels of proinflammatory cytokines and biomarkers of matrix remodeling in never-treated patients with familial hypercholesterolemia. Clin Chim Acta (2005) 0.84
A perfusion bioreactor for engineering bone constructs: an in vitro and in vivo study. Tissue Eng Part C Methods (2011) 0.84
Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1. Metabolism (2007) 0.83
Serum tissue inhibitors of metalloproteinases 1 (TIMP-1) and carotid atherosclerosis and aortic arterial stiffness. J Hypertens (2005) 0.83
Cholesteryl ester hydroperoxides increase macrophage CD36 gene expression via PPARalpha. Biochem Biophys Res Commun (2006) 0.83
Resveratrol opposite effects on rat tissue lipoperoxidation: pro-oxidant during day-time and antioxidant at night. Redox Rep (2009) 0.82
Daily melatonin supplementation in mice increases atherosclerosis in proximal aorta. Biochem Biophys Res Commun (2002) 0.82
Fructose 1,6-bisphosphatase deficiency: clinical, biochemical and genetic features in French patients. J Inherit Metab Dis (2015) 0.82
Increased susceptibility of low-density lipoprotein to ex vivo oxidation in mice transgenic for human apolipoprotein B treated with 1 melatonin-related compound is not associated with atherosclerosis progression. J Cardiovasc Pharmacol (2005) 0.82
Implication of cytosolic phospholipase A2 (cPLA2) in the regulation of human synoviocyte NADPH oxidase (Nox2) activity. Life Sci (2007) 0.82
Real time identification of drug-induced liver injury (DILI) through daily screening of ALT results: a prospective pilot cohort study. PLoS One (2012) 0.81
A novel mutation in the human complex I NDUFS7 subunit associated with Leigh syndrome. Mol Genet Metab (2007) 0.81
Metformin suppresses high glucose-induced poly(adenosine diphosphate-ribose) polymerase overactivation in aortic endothelial cells. Metabolism (2009) 0.80
Insulin resistance and inflammation predict kinetic body weight changes in response to dietary weight loss and maintenance in overweight and obese subjects by using a Bayesian network approach. Am J Clin Nutr (2013) 0.80
Chain-breaking activity of resveratrol and piceatannol in a linoleate micellar model. Chem Phys Lipids (2008) 0.80
Melatonin protects PLPC liposomes and LDL towards radical-induced oxidation. J Pineal Res (2011) 0.80
S100B blood level measurement to exclude cerebral lesions after minor head injury: the multicenter STIC-S100 French study. Clin Chem Lab Med (2014) 0.80
Protective effects of regulatory amino acids on ischemia-reperfusion injury in the isolated perfused rat liver. Scand J Gastroenterol (2006) 0.80
Expression and extracellular release of Trx80, the truncated form of thioredoxin, by TNF-alpha- and IL-1beta-stimulated human synoviocytes from patients with rheumatoid arthritis. Clin Sci (Lond) (2007) 0.80
Preanalytical aspects regarding the measurement of metalloproteinase-9 and tissue inhibitor or metalloproteinase-1 in blood. Clin Chim Acta (2002) 0.80
Oxidative stress in patients with acute heart failure. Rejuvenation Res (2008) 0.80
Activation of PAF receptor by oxidised LDL in human monocytes stimulates chemokine releases but not urokinase-type plasminogen activator expression. Clin Chim Acta (2004) 0.80
Oxidative stress implication in a new ex-vivo cardiac concordant xenotransplantation model. Free Radic Res (2007) 0.80
Rapid screening for nuclear genes mutations in isolated respiratory chain complex I defects. Mol Genet Metab (2009) 0.79
Dual effects of resveratrol on arterial damage induced by insulin resistance in aged mice. J Gerontol A Biol Sci Med Sci (2013) 0.79
Comparative effects of two type I interferons, human IFN-alpha and ovine IFN-tau on indoleamine-2,3-dioxygenase in primary cultures of human macrophages. Fundam Clin Pharmacol (2007) 0.79
High-Sensitivity Cardiac Troponin T: a Preanalytical Evaluation. Clin Lab (2016) 0.79
Cystatin C as a marker of early changes of renal function in Fabry nephropathy. J Nephrol (2007) 0.79
Possible mechanisms involved in the discrepancy of hepatic and aortic endothelial nitric oxide synthases during the development of cirrhosis in rats. Liver Int (2009) 0.79
Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats. World J Gastroenterol (2006) 0.79
Piceatannol is more effective than resveratrol in restoring endothelial cell dimethylarginine dimethylaminohydrolase expression and activity after high-glucose oxidative stress. Free Radic Res (2011) 0.78
Plasma NOV/CCN3 levels are closely associated with obesity in patients with metabolic disorders. PLoS One (2013) 0.78
Blood pressure-lowering response to amlodipine as a determinant of the antioxidative activity of small, dense HDL3. Am J Cardiovasc Drugs (2011) 0.78
Quantification of the water/lipid affinity of melatonin and a pinoline derivative in lipid models. J Pineal Res (2007) 0.78
Hypoxia induces nitric oxide synthase in rheumatoid synoviocytes: consequences on NADPH oxidase regulation. Free Radic Res (2012) 0.78
Impact of LDL apheresis on atheroprotective reverse cholesterol transport pathway in familial hypercholesterolemia. J Lipid Res (2012) 0.78