Published in Expert Opin Biol Ther on April 01, 2005
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Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-/-) mice. Hepatology (2009) 1.11
Distinct roles of helper T-cell subsets in a systemic autoimmune disease. Blood (2008) 1.04
Demonstration of low-regulatory CD25High+CD4+ and high-pro-inflammatory CD28-CD4+ T-Cell subsets in patients with ulcerative colitis: modified by selective granulocyte and monocyte adsorption apheresis. Dig Dis Sci (2007) 0.95
Rhinosinusitis derived Staphylococcal enterotoxin B possibly associates with pathogenesis of ulcerative colitis. BMC Gastroenterol (2005) 0.95
Positions of selective leukocytapheresis in the medical therapy of ulcerative colitis. World J Gastroenterol (2006) 0.90
Autoimmunity in common variable immunodeficiency. J Clin Immunol (2008) 0.88
Treating inflammatory bowel disease by adsorptive leucocytapheresis: a desire to treat without drugs. World J Gastroenterol (2014) 0.86
Adacolumn selective leukocyte adsorption apheresis in patients with active ulcerative colitis: clinical efficacy, effects on plasma IL-8, and expression of Toll-like receptor 2 on granulocytes. Dig Dis Sci (2007) 0.85
Bacterial superantigens and T cell receptor beta-chain-bearing T cells in the immunopathogenesis of ulcerative colitis. Clin Exp Immunol (2007) 0.83
The expression profile of functional regulatory T cells, CD4+CD25high+/forkhead box protein P3+, in patients with ulcerative colitis during active and quiescent disease. Clin Exp Immunol (2009) 0.82
Preventive and therapeutic effects of tacrolimus in an interleukin-10-deficient mouse model of colitis. Inflamm Res (2011) 0.78
α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C. Hepatology (2013) 3.27
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat Med (2012) 3.17
MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J Gastroenterol (2005) 3.02
Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat Med (2002) 2.18
Effects of family history on inflammatory bowel disease characteristics in Japanese patients. J Gastroenterol (2012) 2.17
Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep (2003) 2.16
Specific inhibition of hepatitis C virus replication by cyclosporin A. Biochem Biophys Res Commun (2004) 1.93
CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells. J Immunol (2004) 1.89
Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins. Gastroenterology (2005) 1.85
Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. J Hepatol (2010) 1.80
Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J Gastroenterol (2007) 1.75
Characteristics of international medical graduates who applied to the CaRMS 2002 match. CMAJ (2003) 1.68
Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation. RNA (2008) 1.66
Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J Biol Chem (2002) 1.61
Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol (2003) 1.57
Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha. J Infect Dis (2004) 1.55
Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol (2008) 1.42
Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3. J Gastroenterol (2006) 1.41
Evidence-based clinical practice guidelines for Crohn's disease, integrated with formal consensus of experts in Japan. J Gastroenterol (2012) 1.40
Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell (2013) 1.39
A novel apoptosis-inducing monoclonal antibody (anti-LHK) against a cell surface antigen on colon cancer cells. J Gastroenterol (2005) 1.39
Prevalence of ulcerative colitis and Crohn's disease in Japan. J Gastroenterol (2009) 1.39
Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. J Immunol (2003) 1.37
Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells (2003) 1.33
Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein. Hepatology (2009) 1.33
Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology (2002) 1.29
Phylogenetic analysis of spotted fever group rickettsiae based on gltA, 17-kDa, and rOmpA genes amplified by nested PCR from ticks in Japan. Microbiol Immunol (2003) 1.29
Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells. J Immunol (2003) 1.28
IL-7 Is essential for the development and the persistence of chronic colitis. J Immunol (2007) 1.27
Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol (2009) 1.27
Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. Gastroenterology (2006) 1.21
Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol (2007) 1.21
Negative frequency-dependent selection in female color polymorphism of a damselfly. Evolution (2010) 1.19
Canadian and immigrant international medical graduates. Can Fam Physician (2005) 1.16
Cellular and molecular mechanisms of the epithelial repair in IBD. Dig Dis Sci (2005) 1.16
Regulation of hepatitis C virus replication by interferon regulatory factor 1. J Virol (2004) 1.16
Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol (2004) 1.15
Molecular and clinical basis for the regeneration of human gastrointestinal epithelia. J Gastroenterol (2004) 1.12
MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis. J Immunol (2008) 1.12
Efficacy and safety of adalimumab in Japanese patients with moderately to severely active ulcerative colitis. J Gastroenterol (2013) 1.12
Redoxable nanosheet crystallites of MnO2 derived via delamination of a layered manganese oxide. J Am Chem Soc (2003) 1.11
IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice. Am J Physiol Gastrointest Liver Physiol (2004) 1.10
Phylogenetic analysis of spotted fever group Rickettsiae isolated from ticks in Japan. Microbiol Immunol (2002) 1.09
ITPA gene variant protects against anemia induced by pegylated interferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C. Hepatol Res (2010) 1.09
Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease. Gastroenterology (2004) 1.09
Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis. Inflamm Bowel Dis (2011) 1.08
Regulatory interaction of HNF1-alpha to microRNA-194 gene during intestinal epithelial cell differentiation. Nucleic Acids Symp Ser (Oxf) (2007) 1.07
RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis. J Immunol (2009) 1.06
Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology (2005) 1.05
Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity. Hepatology (2013) 1.03
Autoimmune pancreatitis complicated with inflammatory bowel disease and comparative study of type 1 and type 2 autoimmune pancreatitis. J Gastroenterol (2014) 1.02
Inflammatory bowel disease in children: epidemiological analysis of the nationwide IBD registry in Japan. J Gastroenterol (2010) 1.02
Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease. J Gastroenterol (2009) 1.02
Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity. Virology (2007) 1.02
Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91. J Virol (2011) 1.01
Chronic hepatitis delta virus infection with genotype IIb variant is correlated with progressive liver disease. J Gen Virol (2003) 1.00
IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. FEBS Lett (2005) 0.99
Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement. Am J Gastroenterol (2002) 0.98
Extracorporeal elimination of TNF-alpha-producing CD14(dull)CD16(+) monocytes in leukocytapheresis therapy for ulcerative colitis. Inflamm Bowel Dis (2007) 0.95
Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice. J Gastroenterol Hepatol (2003) 0.95
Morph-specific fecundity and egg size in the female-dimorphic damselfly Ischnura senegalensis. Zoolog Sci (2010) 0.94
Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells. J Gastroenterol (2009) 0.94
Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b. J Med Virol (2011) 0.94
Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology (2006) 0.93
Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis. J Immunol (2009) 0.92
Quantitation of the level of hepatitis delta virus RNA in serum, by real-time polymerase chain reaction--and its possible correlation with the clinical stage of liver disease. J Infect Dis (2004) 0.92
A geographic cline induced by negative frequency-dependent selection. BMC Evol Biol (2011) 0.92
A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression. Hepatol Res (2002) 0.92
TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy (2015) 0.91
Ectopic CD40 ligand expression on B cells triggers intestinal inflammation. J Immunol (2004) 0.91
Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. Biochem Biophys Res Commun (2008) 0.91
Continuity and change of Japanese encephalitis virus in Toyama Prefecture, Japan. Am J Trop Med Hyg (2011) 0.91
Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy. J Gastroenterol Hepatol (2005) 0.91
Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology (2003) 0.90
Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease. Curr Opin Gastroenterol (2009) 0.90
C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn's disease. J Gastroenterol (2013) 0.90
Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response. J Gen Virol (2007) 0.90
Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease. Inflamm Bowel Dis (2010) 0.89
Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells. Biochem Biophys Res Commun (2010) 0.89
Evaluation of diagnostic criteria for Crohn's disease in Japan. J Gastroenterol (2013) 0.89
Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother (2010) 0.88
TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice. Inflamm Bowel Dis (2006) 0.88
IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis. Eur J Immunol (2010) 0.88
Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis. Clin Colorectal Cancer (2011) 0.88
Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C. J Gastroenterol (2013) 0.88
Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-α2b plus ribavirin. Antivir Ther (2011) 0.87
Evidence-based clinical practice guidelines for management of colorectal polyps. J Gastroenterol (2015) 0.87
The logics of leukocytapheresis as a natural biological therapy for inflammatory bowel disease. Expert Opin Biol Ther (2006) 0.87
T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice. Gastroenterology (2012) 0.87
Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-alpha-mediated apoptosis in Huh7 cells. J Infect Dis (2003) 0.87
Sargramostim in patients with Crohn's disease: results of a phase 1-2 study. J Gastroenterol (2009) 0.87
Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan. J Crohns Colitis (2011) 0.87
Changes of HCV quasispecies during combination therapy with interferon and ribavirin. Hepatol Res (2004) 0.87
Clinical significance of microsatellite instability in the inflamed mucosa for the prediction of colonic neoplasms in patients with ulcerative colitis. J Gastroenterol Hepatol (2005) 0.86
New therapeutic approaches to hepatitis C virus. J Gastroenterol (2009) 0.86
Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication. Hepatol Res (2005) 0.86
Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J Immunol (2011) 0.86
A prospective analysis of the incidence of and risk factors for opportunistic infections in patients with inflammatory bowel disease. J Gastroenterol (2012) 0.85
Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells. Eur J Immunol (2005) 0.85