Published in Acta Crystallogr D Biol Crystallogr on June 24, 2005
Glycal formation in crystals of uridine phosphorylase. Biochemistry (2010) 0.98
Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. BMC Struct Biol (2009) 0.89
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol (2010) 0.88
The crystal structure of Streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases. Biochemistry (2011) 0.82
A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity. J Struct Biol (2011) 0.78
Active site conformational dynamics in human uridine phosphorylase 1. PLoS One (2010) 0.77
Expression, purification, crystallization and preliminary X-ray structure analysis of Vibrio cholerae uridine phosphorylase in complex with thymidine. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.77
Inferences from structural comparison: flexibility, secondary structure wobble and sequence alignment optimization. BMC Bioinformatics (2012) 0.77
Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A (2009) 2.65
The structural and biochemical foundations of thiamin biosynthesis. Annu Rev Biochem (2009) 2.32
Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers. Proc Natl Acad Sci U S A (2011) 2.08
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nat Chem Biol (2008) 1.96
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature (2010) 1.85
Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs. J Virol (2010) 1.78
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci U S A (2012) 1.70
Structural analyses reveal two distinct families of nucleoside phosphorylases. Biochem J (2002) 1.69
Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. Science (2009) 1.66
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Structure (2003) 1.54
Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. PLoS Pathog (2011) 1.53
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature (2011) 1.50
Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis. Biochemistry (2006) 1.42
Flavogenomics--a genomic and structural view of flavin-dependent proteins. FEBS J (2011) 1.40
Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution. Biochemistry (2002) 1.39
Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution. Structure (2002) 1.39
Structural biology of enzymes of the thiamin biosynthesis pathway. Curr Opin Struct Biol (2003) 1.37
Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis. Biochemistry (2003) 1.35
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. EMBO Rep (2011) 1.31
Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis. Biochemistry (2007) 1.29
Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. J Am Chem Soc (2007) 1.29
Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry (2005) 1.25
Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae. Biochemistry (2006) 1.20
Enzymatic reactions involving novel mechanisms of carbanion stabilization. Curr Opin Chem Biol (2004) 1.20
Thiamin biosynthesis in eukaryotes: characterization of the enzyme-bound product of thiazole synthase from Saccharomyces cerevisiae and its implications in thiazole biosynthesis. J Am Chem Soc (2006) 1.19
Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase. J Biol Chem (2003) 1.14
Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis. Biochemistry (2005) 1.12
Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase. J Biol Chem (2004) 1.07
Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex. Biochemistry (2004) 1.07
Structural insights into the mechanism of the PLP synthase holoenzyme from Thermotoga maritima. Biochemistry (2006) 1.05
Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant. Biochemistry (2003) 1.05
Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles. J Mol Biol (2012) 1.04
Cofactor biosynthesis--still yielding fascinating new biological chemistry. Curr Opin Chem Biol (2008) 1.04
Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution. Acta Crystallogr D Biol Crystallogr (2006) 1.03
Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. J Am Chem Soc (2008) 1.02
Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry (2004) 1.02
Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis. Biochemistry (2008) 1.02
Pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii: crystal structures of the self-cleaved and S53A proenzyme forms. Structure (2003) 1.01
Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry (2006) 1.01
O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis. Biochemistry (2008) 1.00
Glycal formation in crystals of uridine phosphorylase. Biochemistry (2010) 0.98
Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily. Structure (2004) 0.97
Pyridoxal phosphate: biosynthesis and catabolism. Biochim Biophys Acta (2011) 0.97
Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis. Mol Biosyst (2010) 0.97
Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.97
Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Biochemistry (2008) 0.96
Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate. J Am Chem Soc (2012) 0.95
Thiamin phosphate synthase: the rate of pyrimidine carbocation formation. J Am Chem Soc (2007) 0.95
Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase. Biochemistry (2008) 0.95
6-Benzylthioinosine analogues: promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 (es). Biochem Pharmacol (2005) 0.94
Structures of purine 2'-deoxyribosyltransferase, substrate complexes, and the ribosylated enzyme intermediate at 2.0 A resolution. Biochemistry (2004) 0.94
The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Acta Crystallogr D Biol Crystallogr (2006) 0.94
Structural biology of S-adenosylmethionine decarboxylase. Amino Acids (2009) 0.94
Structural studies of thiamin monophosphate kinase in complex with substrates and products. Biochemistry (2008) 0.93
Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis. J Biol Chem (2003) 0.93
Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. J Med Chem (2004) 0.91
The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation. Biochemistry (2004) 0.91
Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents. Biochem Pharmacol (2007) 0.91
A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase. J Am Chem Soc (2011) 0.90
A maize thiamine auxotroph is defective in shoot meristem maintenance. Plant Cell (2010) 0.90
N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis. Biochemistry (2007) 0.90
A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry (2004) 0.89
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine. J Med Chem (2009) 0.89
The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization. J Biol Chem (2011) 0.89
High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes . Biochemistry (2010) 0.88
Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system. Chem Biol (2003) 0.88
Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE). Acta Crystallogr D Biol Crystallogr (2004) 0.88
Catalysis of a flavoenzyme-mediated amide hydrolysis. J Am Chem Soc (2010) 0.88
Thiamin biosynthesis: still yielding fascinating biological chemistry. Biochem Soc Trans (2012) 0.88
Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design. Biochemistry (2004) 0.88
Structural and mechanistic studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. J Biol Chem (2010) 0.88
PNP anticancer gene therapy. Curr Top Med Chem (2005) 0.87
Purification, crystallization and preliminary X-ray analysis of uridine phosphorylase from Salmonella typhimurium. Acta Crystallogr D Biol Crystallogr (2004) 0.87
Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation. Biochemistry (2002) 0.87
Structure determination and characterization of the vitamin B6 degradative enzyme (E)-2-(acetamidomethylene)succinate hydrolase. Biochemistry (2010) 0.87
Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase. Acta Crystallogr D Biol Crystallogr (2007) 0.86
Biochemistry: molecular cannibalism. Nature (2007) 0.86
6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities. Biochem Pharmacol (2005) 0.86
Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase. Biochemistry (2009) 0.86
The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds. J Mol Biol (2005) 0.86
Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase. J Med Chem (2008) 0.86
Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications. Biochemistry (2009) 0.86
Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis. Bioorg Chem (2007) 0.86
Biochemical and structural characterization of a ureidoglycine aminotransferase in the Klebsiella pneumoniae uric acid catabolic pathway. Biochemistry (2010) 0.85
Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase. Acta Crystallogr D Biol Crystallogr (2003) 0.85
A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase. Biochemistry (2007) 0.85
Structure of a Clostridium botulinum C143S thiaminase I/thiamin complex reveals active site architecture . Biochemistry (2013) 0.85
In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase. J Chem Inf Model (2007) 0.85
Reversal of the substrate specificity of CMP N-glycosidase to dCMP. Biochemistry (2013) 0.85
Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation. Eur J Biochem (2004) 0.84
Toxoflavin lyase requires a novel 1-His-2-carboxylate facial triad. Biochemistry (2011) 0.84
Structure of human desArg-C5a. Acta Crystallogr D Biol Crystallogr (2010) 0.84
A localized specific interaction alters the unfolding pathways of structural homologues. J Am Chem Soc (2006) 0.84
Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry (2008) 0.84
Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases. Structure (2004) 0.84
Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex. J Biol Chem (2005) 0.84
The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate. Biochemistry (2005) 0.83
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry (2007) 0.83