Published in Mol Cell on July 01, 2005
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe (2009) 4.24
Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication. J Virol (2009) 2.26
Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro. J Virol (2008) 2.22
Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proc Natl Acad Sci U S A (2008) 2.15
Cellular proteins in influenza virus particles. PLoS Pathog (2008) 1.96
Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog (2009) 1.94
Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. EMBO J (2006) 1.89
The isomerase active site of cyclophilin A is critical for hepatitis C virus replication. J Biol Chem (2009) 1.79
Diverse effects of cyclosporine on hepatitis C virus strain replication. J Virol (2006) 1.72
New antiviral therapies for chronic hepatitis C. Hepatol Int (2010) 1.71
Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity. J Virol (2006) 1.69
NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon. Antimicrob Agents Chemother (2006) 1.69
The dependence of viral RNA replication on co-opted host factors. Nat Rev Microbiol (2011) 1.66
Studying hepatitis C virus: making the best of a bad virus. J Virol (2007) 1.62
Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. J Biol Chem (2009) 1.61
Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell (2012) 1.61
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One (2010) 1.59
Target cell cyclophilins facilitate human papillomavirus type 16 infection. PLoS Pathog (2009) 1.57
Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro. J Virol (2007) 1.53
Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex. J Virol (2009) 1.50
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent. Antimicrob Agents Chemother (2008) 1.46
DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation. J Virol (2010) 1.45
HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J Hepatol (2010) 1.43
A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach. PLoS Pathog (2010) 1.38
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase. J Biol Chem (2008) 1.35
Cyclophilins facilitate dissociation of the human papillomavirus type 16 capsid protein L1 from the L2/DNA complex following virus entry. J Virol (2012) 1.34
Towards a small animal model for hepatitis C. EMBO Rep (2009) 1.34
Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A. PLoS One (2010) 1.29
Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein. PLoS Pathog (2007) 1.29
Hepatitis C virus proteins. World J Gastroenterol (2007) 1.28
Molecular virology of hepatitis C virus (HCV): 2006 update. Int J Med Sci (2006) 1.24
Prevention of hepatocellular carcinoma: potential targets, experimental models, and clinical challenges. Curr Cancer Drug Targets (2012) 1.23
Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner. J Virol (2011) 1.22
Mechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors. Antimicrob Agents Chemother (2010) 1.21
Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP). Hepatology (2014) 1.19
Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. PLoS Biol (2010) 1.18
An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. J Virol (2007) 1.16
The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. PLoS Pathog (2011) 1.14
Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A. J Biol Chem (2011) 1.13
Severe osteogenesis imperfecta in cyclophilin B-deficient mice. PLoS Genet (2009) 1.12
Combinations of cyclophilin inhibitor NIM811 with hepatitis C Virus NS3-4A Protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance. Antimicrob Agents Chemother (2008) 1.11
Curing a viral infection by targeting the host: the example of cyclophilin inhibitors. Antiviral Res (2013) 1.10
Specifically targeted antiviral therapy for hepatitis C virus. World J Gastroenterol (2007) 1.10
Quantification system for the viral dynamics of a highly pathogenic simian/human immunodeficiency virus based on an in vitro experiment and a mathematical model. Retrovirology (2012) 1.06
New and experimental therapies for HCV. Nat Rev Gastroenterol Hepatol (2009) 1.05
Hepatitis C virus co-opts Ras-GTPase-activating protein-binding protein 1 for its genome replication. J Virol (2011) 1.03
Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication. J Virol (2007) 1.03
Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein. Antimicrob Agents Chemother (2009) 1.03
Calcineurin regulation in fungi and beyond. Eukaryot Cell (2007) 1.02
Treatment failure in hepatitis C: mechanisms of non-response. J Hepatol (2008) 1.02
Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat Chem Biol (2010) 1.02
Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions. J Virol (2010) 1.01
Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. Antimicrob Agents Chemother (2007) 1.01
Current status and future directions in the management of chronic hepatitis C. Virol J (2012) 0.99
Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagation. J Virol (2011) 0.98
Cyclophilin A associates with enterovirus-71 virus capsid and plays an essential role in viral infection as an uncoating regulator. PLoS Pathog (2014) 0.98
CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells. J Virol (2010) 0.98
Hepatitis C virus-host interactions, replication, and viral assembly. Curr Opin Virol (2012) 0.97
Fusion of cyclophilin A to Fv1 enables cyclosporine-sensitive restriction of human and feline immunodeficiency viruses. J Virol (2007) 0.97
Lipid metabolism and HCV infection. Viruses (2010) 0.96
Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein. J Virol (2009) 0.96
Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A. Hepatology (2009) 0.95
Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner. J Virol (2010) 0.95
A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A. PLoS One (2011) 0.94
Microbial peptidyl-prolyl cis/trans isomerases (PPIases): virulence factors and potential alternative drug targets. Microbiol Mol Biol Rev (2014) 0.93
A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication. J Virol (2008) 0.93
Targeting host factors: a novel rationale for the management of hepatitis C virus. World J Gastroenterol (2009) 0.93
Isoform-specific inhibition of cyclophilins. Biochemistry (2009) 0.92
Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway. J Virol (2009) 0.92
Exploitation of lipid components by viral and host proteins for hepatitis C virus infection. Front Microbiol (2012) 0.92
Cyclosporine inhibits mouse cytomegalovirus infection via a cyclophilin-dependent pathway specifically in neural stem/progenitor cells. J Virol (2007) 0.92
Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus. J Mol Biol (2007) 0.91
Host-Targeting Agents to Prevent and Cure Hepatitis C Virus Infection. Viruses (2015) 0.91
A host small GTP-binding protein ARL8 plays crucial roles in tobamovirus RNA replication. PLoS Pathog (2011) 0.90
Anti-HCV drugs in the pipeline. Curr Opin Virol (2011) 0.90
1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors. Antimicrob Agents Chemother (2008) 0.90
New treatments for chronic hepatitis C. Korean J Hepatol (2010) 0.89
Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B. Cancer Cell Int (2012) 0.89
Cyclosporin A inhibits the influenza virus replication through cyclophilin A-dependent and -independent pathways. PLoS One (2012) 0.89
Genome-wide analysis of host mRNA translation during hepatitis C virus infection. J Virol (2013) 0.89
Cyclophilins as modulators of viral replication. Viruses (2013) 0.88
Natural products as promising drug candidates for the treatment of hepatitis B and C. Acta Pharmacol Sin (2008) 0.88
PCBP2 enhances the antiviral activity of IFN-α against HCV by stabilizing the mRNA of STAT1 and STAT2. PLoS One (2011) 0.87
Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family. Antimicrob Agents Chemother (2011) 0.87
Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A. J Biol Chem (2012) 0.87
Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors. J Virol (2012) 0.86
Cyclosporin A inhibits the replication of diverse coronaviruses. J Gen Virol (2011) 0.86
Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase. Biochem Pharmacol (2009) 0.86
Cyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes. J Gen Virol (2010) 0.86
Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells. Cancer Res (2013) 0.86
Cyclophilin inhibitors block arterivirus replication by interfering with viral RNA synthesis. J Virol (2012) 0.86
New therapeutic opportunities for hepatitis C based on small RNA. World J Gastroenterol (2007) 0.86
Cyclophilin and viruses: cyclophilin as a cofactor for viral infection and possible anti-viral target. Drug Target Insights (2007) 0.86
Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion. Virol J (2011) 0.85
HuR Displaces Polypyrimidine Tract Binding Protein To Facilitate La Binding to the 3' Untranslated Region and Enhances Hepatitis C Virus Replication. J Virol (2015) 0.84
Treating hepatitis C infection by targeting the host. Transl Res (2012) 0.84
Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses. PLoS One (2014) 0.84
The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol (2007) 8.98
ATP drives lamina propria T(H)17 cell differentiation. Nature (2008) 8.02
Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells (2006) 5.68
MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science (2007) 4.33
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet (2005) 3.86
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene (2003) 3.53
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Natl Acad Sci U S A (2007) 2.88
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology (2003) 2.76
OX40 costimulation turns off Foxp3+ Tregs. Blood (2007) 2.52
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun (2013) 2.31
Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. J Immunol (2004) 2.28
Regulation of the hepatitis C virus genome replication by miR-199a. J Hepatol (2008) 2.26
Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol (2004) 2.12
Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology (2003) 2.10
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci U S A (2011) 1.97
A genome-wide association study identifies RNF213 as the first Moyamoya disease gene. J Hum Genet (2010) 1.97
Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes. J Hepatol (2006) 1.89
Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Blood (2005) 1.85
A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Res (2010) 1.83
Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev (2004) 1.83
The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One (2011) 1.81
During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion. J Immunol (2005) 1.81
The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology (2004) 1.81
Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion. Blood (2004) 1.78
Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication. J Biol Chem (2003) 1.77
Diverse effects of cyclosporine on hepatitis C virus strain replication. J Virol (2006) 1.72
HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene (2005) 1.66
Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification. J Biol Chem (2004) 1.66
TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest (2004) 1.63
The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). Int Immunol (2009) 1.59
Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.57
Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. Circulation (2006) 1.53
Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway. J Immunol (2008) 1.50
Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin. Clin Cancer Res (2007) 1.48
Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J Virol (2011) 1.47
Establishment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica. Tohoku J Exp Med (2006) 1.46
Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease. J Am Geriatr Soc (2006) 1.45
Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta. Endocrinology (2002) 1.40
Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms. J Virol (2010) 1.39
Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus. Mol Cell Biol (2003) 1.37
Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur J Immunol (2003) 1.37
Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation. Biochem Biophys Res Commun (2003) 1.36
Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. J Infect Dis (2003) 1.35
Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811. Biochem Biophys Res Commun (2006) 1.32
Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense. Proc Natl Acad Sci U S A (2010) 1.31
c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130. Mol Cell Biol (2008) 1.31
Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. Circ Res (2007) 1.31
Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma. Blood (2002) 1.31
Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice. J Reprod Immunol (2010) 1.27
UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I. Mol Immunol (2007) 1.27
Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon. J Virol (2004) 1.26
Homologous recombinational repair factors are recruited and loaded onto the viral DNA genome in Epstein-Barr virus replication compartments. J Virol (2009) 1.25
Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4. J Biol Chem (2003) 1.22
Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells. Int Immunol (2005) 1.21
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. J Clin Invest (2007) 1.21
Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J Immunol (2002) 1.20
Subgenomic replicon derived from a cell line infected with the hepatitis C virus. Biochem Biophys Res Commun (2002) 1.19
A signal adaptor SLAM-associated protein regulates spontaneous autoimmunity and Fas-dependent lymphoproliferation in MRL-Faslpr lupus mice. J Immunol (2006) 1.17
Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E. J Biol Chem (2006) 1.16
Establishment of a hepatitis C virus subgenomic replicon derived from human hepatocytes infected in vitro. Biochem Biophys Res Commun (2003) 1.13
Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice. J Biol Chem (2002) 1.13
Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts. J Virol (2007) 1.13
OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. J Immunol (2008) 1.12
The human cytomegalovirus gene products essential for late viral gene expression assemble into prereplication complexes before viral DNA replication. J Virol (2011) 1.12
Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines. Cancer Sci (2010) 1.10
Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse. Int Immunol (2012) 1.10
OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity. J Immunol (2006) 1.10
Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J Immunol (2007) 1.10
Hepatitis C virus utilizes lipid droplet for production of infectious virus. Proc Jpn Acad Ser B Phys Biol Sci (2009) 1.09
Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1. Cardiovasc Res (2008) 1.09
OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo. J Immunol (2008) 1.09
The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. Oncogene (2002) 1.08
Heat-shock protein 90 is essential for stabilization of the hepatitis C virus nonstructural protein NS3. J Biol Chem (2009) 1.08
The Tohoku Medical Megabank Project: Design and Mission. J Epidemiol (2016) 1.08
Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor. Cancer Sci (2009) 1.07
Down-regulation of viral replication by adenoviral-mediated expression of siRNA against cellular cofactors for hepatitis C virus. Virology (2004) 1.07
Suppression of hepatitis C virus replicon by TGF-beta. Virology (2005) 1.05
Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C. BMC Med Genomics (2010) 1.04
Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets. Int Immunol (2007) 1.04
Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction. PLoS One (2010) 1.04