Published in Biochimie on December 10, 2004
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev (2007) 4.60
Replication fork stalling at natural impediments. Microbiol Mol Biol Rev (2007) 3.47
Replication licensing and cancer--a fatal entanglement? Nat Rev Cancer (2008) 2.86
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res (2011) 1.78
Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex. Mol Cell Biol (2006) 1.73
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J Cell Biol (2010) 1.63
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem (2008) 1.61
How dormant origins promote complete genome replication. Trends Biochem Sci (2011) 1.60
Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast. Cell Cycle (2010) 1.58
Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks. J Biol Chem (2009) 1.54
Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. Genes Dev (2006) 1.51
Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism. Genes Dev (2009) 1.50
Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. Proc Natl Acad Sci U S A (2007) 1.32
DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore. PLoS Genet (2008) 1.31
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells. J Biol Chem (2009) 1.29
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst) (2009) 1.29
Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint. Mol Biol Cell (2007) 1.28
Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J Cell Biol (2010) 1.27
Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability. Mol Cell Biol (2008) 1.21
HARPing on about the DNA damage response during replication. Genes Dev (2009) 1.21
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene (2008) 1.20
Roles of the Werner syndrome RecQ helicase in DNA replication. DNA Repair (Amst) (2008) 1.20
Molecular mimicry of SUMO promotes DNA repair. Nat Struct Mol Biol (2009) 1.14
Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint. EMBO Rep (2009) 1.10
Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin. Mol Biol Cell (2011) 1.09
Replication stress checkpoint signaling controls tRNA gene transcription. Nat Struct Mol Biol (2010) 1.06
The human intra-S checkpoint response to UVC-induced DNA damage. Carcinogenesis (2009) 1.05
Proteomic analysis of the Kaposi's sarcoma-associated herpesvirus terminal repeat element binding proteins. J Virol (2006) 1.04
The uvrA, uvrB and uvrC genes are required for repair of ultraviolet light induced DNA photoproducts in Halobacterium sp. NRC-1. Saline Systems (2006) 1.02
Impediments to replication fork movement: stabilisation, reactivation and genome instability. Chromosoma (2013) 1.02
Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae. PLoS Genet (2008) 1.00
Dormant origins, the licensing checkpoint, and the response to replicative stresses. Cold Spring Harb Perspect Biol (2012) 0.99
Repair of DNA interstrand cross-links during S phase of the mammalian cell cycle. Environ Mol Mutagen (2010) 0.99
Replication checkpoint: tuning and coordination of replication forks in s phase. Genes (Basel) (2013) 0.95
Molecular architecture of a eukaryotic DNA replication terminus-terminator protein complex. Mol Cell Biol (2006) 0.92
HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells. Neoplasia (2013) 0.92
TIF1 activates the intra-S-phase checkpoint response in the diploid micronucleus and amitotic polyploid macronucleus of Tetrahymena. Mol Biol Cell (2006) 0.90
Checkpoint functions are required for normal S-phase progression in Saccharomyces cerevisiae RCAF- and CAF-I-defective mutants. Proc Natl Acad Sci U S A (2006) 0.89
Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E. J Biol Chem (2009) 0.89
Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae. DNA Repair (Amst) (2008) 0.88
Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest. J Biol Chem (2009) 0.87
Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation. Nucleic Acids Res (2010) 0.86
Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae. Genetics (2010) 0.86
The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins. J Cell Sci (2014) 0.86
Checkpoint-dependent regulation of origin firing and replication fork movement in response to DNA damage in fission yeast. Mol Cell Biol (2008) 0.85
Is homologous recombination really an error-free process? Front Genet (2014) 0.85
Genome stability control by checkpoint regulation of tRNA gene transcription. Transcription (2010) 0.83
Schizosaccharomyces pombe Cds1Chk2 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60. J Cell Sci (2009) 0.82
Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract. J Biol Chem (2012) 0.81
Molecular mechanisms of DNA replication checkpoint activation. Genes (Basel) (2014) 0.80
Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress. Mol Cancer Res (2013) 0.79
MRX protects fork integrity at protein-DNA barriers, and its absence causes checkpoint activation dependent on chromatin context. Nucleic Acids Res (2013) 0.79
Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients. Cell Cycle (2015) 0.79
A proposal: Source of single strand DNA that elicits the SOS response. Front Biosci (Landmark Ed) (2013) 0.78
Crystallization and preliminary X-ray characterization of the eukaryotic replication terminator Reb1-Ter DNA complex. Acta Crystallogr F Struct Biol Commun (2015) 0.78
Establishment of a replication fork barrier following induction of DNA binding in mammalian cells. Cell Cycle (2014) 0.78
Ewing Tumor-associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks. J Biol Chem (2016) 0.77
Cell cycle regulation by checkpoints. Methods Mol Biol (2014) 0.77
Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes. Nucleus (2017) 0.75
The checkpoint-dependent nuclear accumulation of Rho1p exchange factor Rgf1p is important for tolerance to chronic replication stress. Mol Biol Cell (2014) 0.75
How to exchange your partner. Workshop on recombination mechanisms and the maintenance of genomic stability. EMBO Rep (2006) 0.75
The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines. Cell Chem Biol (2017) 0.75
Gross chromosomal rearrangements and elevated recombination at an inducible site-specific replication fork barrier. Cell (2005) 2.99
Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst) (2005) 2.46
Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. Genes Dev (2002) 2.37
Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol Cell Biol (2003) 2.33
Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms. Genes Dev (2003) 2.31
Three novel antibiotic marker cassettes for gene disruption and marker switching in Schizosaccharomyces pombe. Yeast (2005) 2.20
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev (2004) 2.16
Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. Mol Cell (2009) 2.12
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell (2009) 2.07
The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell (2012) 2.07
Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase. EMBO J (2005) 1.88
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO J (2003) 1.82
The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved. PLoS Genet (2011) 1.81
Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Proc Natl Acad Sci U S A (2002) 1.75
Arrested replication fork processing: interplay between checkpoints and recombination. DNA Repair (Amst) (2007) 1.65
Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes. Mol Biol Cell (2002) 1.64
Ddb1 controls genome stability and meiosis in fission yeast. Genes Dev (2005) 1.63
Postreplication repair and PCNA modification in Schizosaccharomyces pombe. Mol Biol Cell (2006) 1.57
DDK phosphorylates checkpoint clamp component Rad9 and promotes its release from damaged chromatin. Mol Cell (2010) 1.53
Smc5/6: a link between DNA repair and unidirectional replication? Nat Rev Mol Cell Biol (2008) 1.52
Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates. Mol Cell Biol (2005) 1.50
Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism. Genes Dev (2009) 1.50
Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange. Mol Cell (2010) 1.49
Additional vectors for PCR-based gene tagging in Saccharomyces cerevisiae and Schizosaccharomyces pombe using nourseothricin resistance. Yeast (2005) 1.46
Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast. Open Biol (2012) 1.42
RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light. Nature (2008) 1.32
Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast. Mol Cell Biol (2004) 1.30
Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions. Mol Cell Biol (2009) 1.29
A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proc Natl Acad Sci U S A (2002) 1.23
Gene tagging and gene replacement using recombinase-mediated cassette exchange in Schizosaccharomyces pombe. Gene (2007) 1.19
Recombination-restarted replication makes inverted chromosome fusions at inverted repeats. Nature (2012) 1.15
Replication fork arrest, recombination and the maintenance of ribosomal DNA stability. DNA Repair (Amst) (2008) 1.08
A simple Cre-loxP method for chromosomal N-terminal tagging of essential and non-essential Schizosaccharomyces pombe genes. Gene (2003) 1.06
Impediments to replication fork movement: stabilisation, reactivation and genome instability. Chromosoma (2013) 1.02
Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms. Genes Dev (2010) 1.01
Requirement for DNA ligase IV during embryonic neuronal development. J Neurosci (2011) 1.01
Delineating the position of rad4+/cut5+ within the DNA-structure checkpoint pathways in Schizosaccharomyces pombe. J Cell Sci (2003) 0.95
Replication stress and genome rearrangements: lessons from yeast models. Curr Opin Genet Dev (2012) 0.94
Regulation of gene expression at the fission yeast Schizosaccharomyces pombe urg1 locus. Gene (2011) 0.94
Cell division defects of Schizosaccharomyces pombe liz1- mutants are caused by defects in pantothenate uptake. Eukaryot Cell (2004) 0.91
DNA checkpoints in fission yeast. J Cell Sci (2003) 0.90
The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner. PLoS Genet (2012) 0.90
An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genet (2013) 0.88
Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice. Nat Cell Biol (2007) 0.88
Checkpoints: how to flag up double-strand breaks. Curr Biol (2002) 0.87
Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1. PLoS One (2007) 0.86
CUL4B-deficiency in humans: understanding the clinical consequences of impaired Cullin 4-RING E3 ubiquitin ligase function. Mech Ageing Dev (2011) 0.83
Schizosaccharomyces pombe Cds1Chk2 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60. J Cell Sci (2009) 0.82
Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated. J Cell Sci (2013) 0.82
LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition. Dis Model Mech (2014) 0.81
A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes. Nucleic Acids Res (2013) 0.79
Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination. DNA Repair (Amst) (2010) 0.78
The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe. DNA Repair (Amst) (2009) 0.77
Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition. Nucleic Acids Res (2013) 0.75
Analyzing the Response to Dysfunction Replication Forks Using the RTS1 Barrier System in Fission Yeast. Methods Mol Biol (2015) 0.75