Published in Nat Rev Immunol on July 01, 2005
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Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J Exp Med (2006) 1.51
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Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza. Mol Pharmacol (2008) 1.48
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S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med (2010) 1.43
Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS One (2009) 1.42
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood (2006) 1.41
Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. Am J Respir Cell Mol Biol (2009) 1.36
Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol (2008) 1.36
G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation. Immunol Lett (2007) 1.33
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The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J Biol Chem (2010) 1.29
Hematopoietic stem and progenitor cell trafficking. Trends Immunol (2011) 1.29
Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J Exp Med (2010) 1.28
Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem (2010) 1.27
Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. Mol Cell Biol (2007) 1.26
Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. J Biol Chem (2009) 1.24
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement. Blood (2009) 1.23
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood (2011) 1.19
Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int (2008) 1.14
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The benefits and detriments of macrophages/microglia in models of multiple sclerosis. Clin Dev Immunol (2013) 1.14
Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am J Respir Cell Mol Biol (2010) 1.13
Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med (2007) 1.13
Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. J Lipid Res (2008) 1.13
Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release. Cell Signal (2008) 1.12
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions. Am J Pathol (2008) 1.08
Imaging the choreography of lymphocyte trafficking and the immune response. Curr Opin Immunol (2006) 1.07
Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. J Physiol (2006) 1.07
Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol Cell Biol (2006) 1.07
Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate. J Lipid Res (2010) 1.06
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol (2013) 1.05
Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacol Ther (2007) 1.04
Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. J Lipid Res (2006) 1.04
Novel trafficking routes for hematopoietic stem and progenitor cells. Ann N Y Acad Sci (2009) 1.04
Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions. Immunotherapy (2011) 1.03
Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. J Clin Invest (2014) 1.03
Emerging roles for lysophosphatidylserine in resolution of inflammation. Prog Lipid Res (2012) 1.03
Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. Histochem Cell Biol (2006) 1.02
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Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. Invest Ophthalmol Vis Sci (2006) 0.99
An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. Adv Exp Med Biol (2011) 0.99
Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde. Am J Cancer Res (2011) 0.99
Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection. J Immunol (2008) 0.99
Signal transduction and Th17 cell differentiation. Microbes Infect (2009) 0.98
Targeting cells in motion: migrating toward improved therapies. Eur J Immunol (2013) 0.98
HDL and its sphingosine-1-phosphate content in cardioprotection. Heart Fail Rev (2007) 0.97
The role of sphingosine-1-phosphate and its receptors in asthma. Drug News Perspect (2008) 0.97
Artificial lymph nodes induce potent secondary immune responses in naive and immunodeficient mice. J Clin Invest (2007) 0.96
Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity. J Cell Sci (2011) 0.96
A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. J Biol Chem (2010) 0.95
The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons. J Neurophysiol (2010) 0.94
Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions. PLoS One (2011) 0.94
Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond. Immunology (2014) 0.94
Human cytomegalovirus regulates bioactive sphingolipids. J Biol Chem (2008) 0.93
FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus. J Immunol (2011) 0.93
Oxytocin stimulates migration and invasion in human endothelial cells. Br J Pharmacol (2007) 0.93
Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity. J Virol (2010) 0.93
Sphingolipids in multiple sclerosis. Neuromolecular Med (2010) 0.93
Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model. Prostaglandins Other Lipid Mediat (2008) 0.92
S1P metabolism in cancer and other pathological conditions. Biochimie (2010) 0.92
Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. Kidney Int (2011) 0.92
Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion. Neurosci Lett (2012) 0.92
Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol (2012) 0.91
Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity. Br J Pharmacol (2007) 0.89
Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. FASEB J (2009) 0.89
Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy. Immunol Lett (2011) 0.89
The immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction. J Cardiovasc Pharmacol (2014) 0.88
Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond. Anticancer Agents Med Chem (2011) 0.88
Human immunodeficiency virus type 1 gp120 reprogramming of CD4+ T-cell migration provides a mechanism for lymphadenopathy. J Virol (2009) 0.88
Pharmacological treatment options for mast cell activation disease. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.87
The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J (2004) 3.12
International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev (2002) 2.75
Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J (2002) 1.67
Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia. Am J Physiol Heart Circ Physiol (2007) 1.50
Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am J Physiol Heart Circ Physiol (2002) 1.45
Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation (2004) 1.44
Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. J Immunol (2002) 1.41
c-Maf and JunB mediation of Th2 differentiation induced by the type 2 G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide. J Immunol (2004) 1.30
Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes. J Immunol (2005) 1.29
Lysophospholipids and their G protein-coupled receptors in inflammation and immunity. Biochim Biophys Acta (2002) 1.17
Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. J Immunol (2007) 1.14
Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile. J Immunol (2008) 1.13
Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1. J Biol Chem (2006) 1.13
Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1. J Biol Chem (2003) 1.09
Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration. FASEB J (2005) 1.07
Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor. J Immunol (2003) 1.06
Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice. J Immunol (2003) 1.04
Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J (2008) 1.01
Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2). Oncogene (2004) 1.01
A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function. J Biol Chem (2004) 0.98
Immunoeffector and immunoregulatory activities of vasoactive intestinal peptide. Regul Pept (2002) 0.97
Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic mice. J Immunol (2007) 0.96
Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages. FASEB J (2013) 0.95
Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. J Biol Chem (2003) 0.95
Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. J Immunol (2007) 0.93
Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction. Am J Physiol Heart Circ Physiol (2009) 0.93
Lysophospholipid mediators of immunity and neoplasia. Biochim Biophys Acta (2002) 0.92
Differential signaling of T cell generation of IL-4 by wild-type and short-deletion variant of type 2 G protein-coupled receptor for vasoactive intestinal peptide (VPAC2). J Immunol (2006) 0.89
VPAC1 (vasoactive intestinal peptide (VIP) receptor type 1) G protein-coupled receptor mediation of VIP enhancement of murine experimental colitis. Cell Immunol (2011) 0.89
Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors. J Biol Chem (2006) 0.88
Vasoactive intestinal peptide-mediated Th17 differentiation: an expanding spectrum of vasoactive intestinal peptide effects in immunity and autoimmunity. Ann N Y Acad Sci (2008) 0.87
Lysophospholipid regulation of mononuclear phagocytes. Biochim Biophys Acta (2002) 0.87
Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. FASEB J (2005) 0.85
Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. Clin Immunol (2010) 0.85
Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells. FASEB J (2004) 0.84
Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor. FASEB J (2009) 0.84
Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. J Cell Biochem (2003) 0.82
Human CD4- 8- T cells are a distinctive immunoregulatory subset. FASEB J (2010) 0.81
Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros. J Biol Chem (2002) 0.80
A lymphocyte-generated fragment of vasoactive intestinal peptide with VPAC1 agonist activity and VPAC2 antagonist effects. J Pharmacol Exp Ther (2003) 0.80
Distinct energy requirements for human memory CD4 T-cell homeostatic functions. FASEB J (2012) 0.78
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Functional splice variants of the type II G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide in mouse and human lymphocytes. Ann N Y Acad Sci (2006) 0.78
Distinctive immunoregulatory effects of adenosine on T cells of older humans. FASEB J (2011) 0.77
Is aging a drug target? FASEB J (2011) 0.76