PubRank

Loren G Fong

Author PubWeight™ 116.83‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab 2007 5.04
2 Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci U S A 2005 3.30
3 Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem 2006 3.02
4 Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arterioscler Thromb Vasc Biol 2009 2.99
5 Laminopathies and the long strange trip from basic cell biology to therapy. J Clin Invest 2009 2.94
6 Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis. J Lipid Res 2005 2.88
7 Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. Proc Natl Acad Sci U S A 2005 2.85
8 GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab 2010 2.75
9 A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest 2006 2.39
10 GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons. Curr Opin Lipidol 2007 2.01
11 The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J Biol Chem 2008 1.91
12 Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A 2010 1.89
13 Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Science 2013 1.88
14 Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell 2011 1.86
15 The posttranslational processing of prelamin A and disease. Annu Rev Genomics Hum Genet 2009 1.81
16 Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. J Biol Chem 2008 1.73
17 Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol 2009 1.72
18 Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. J Lipid Res 2009 1.67
19 Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Circ Cardiovasc Genet 2010 1.60
20 Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. J Biol Chem 2009 1.54
21 Prelamin A farnesylation and progeroid syndromes. J Biol Chem 2006 1.43
22 Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated. J Clin Invest 2008 1.40
23 Mouse models of the laminopathies. Exp Cell Res 2007 1.40
24 Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution. Biochim Biophys Acta 2007 1.39
25 An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair. Hum Mol Genet 2011 1.35
26 Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes. Hum Mutat 2007 1.34
27 Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation. Biochim Biophys Acta 2007 1.33
28 An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Genet 2010 1.26
29 Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A 2012 1.26
30 Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem 2010 1.24
31 The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Mol Endocrinol 2008 1.23
32 Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab 2013 1.22
33 Cell nuclei spin in the absence of lamin b1. J Biol Chem 2007 1.22
34 HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A 2007 1.20
35 The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab 2011 1.19
36 GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins. J Lipid Res 2008 1.18
37 Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Hum Mol Genet 2010 1.13
38 Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. J Lipid Res 2008 1.12
39 Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proc Natl Acad Sci U S A 2011 1.10
40 New wrinkles in lipoprotein lipase biology. Curr Opin Lipidol 2012 1.10
41 Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol 2011 1.09
42 Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele. J Biol Chem 2008 1.09
43 Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. Hum Mol Genet 2010 1.09
44 Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Proc Natl Acad Sci U S A 2011 1.09
45 Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. Arterioscler Thromb Vasc Biol 2010 1.08
46 GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res 2011 1.08
47 Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arterioscler Thromb Vasc Biol 2012 1.08
48 Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest 2014 1.07
49 Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase. J Biol Chem 2011 1.07
50 Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Prog Lipid Res 2013 1.06
51 Caution! Analyze transcripts from conditional knockout alleles. Transgenic Res 2008 1.04
52 IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol 2013 1.04
53 PCSK9 function and physiology. J Lipid Res 2008 1.03
54 Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. J Biol Chem 2010 1.03
55 Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A 2013 1.03
56 Protein farnesyltransferase inhibitors and progeria. Trends Mol Med 2006 1.02
57 Investigating the purpose of prelamin A processing. Nucleus 2011 1.01
58 Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria. J Lipid Res 2009 1.01
59 GPIHBP1 and lipolysis: an update. Curr Opin Lipidol 2009 1.00
60 A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J Biol Chem 2008 0.99
61 Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arterioscler Thromb Vasc Biol 2011 0.99
62 A novel approach to tag and identify geranylgeranylated proteins. Electrophoresis 2009 0.98
63 LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins. Nucleus 2011 0.98
64 Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. J Lipid Res 2012 0.98
65 A mouse monoclonal antibody specific for mouse apoB48 and apoB100 produced by immunizing "apoB39-only" mice with mouse apoB48. Biochim Biophys Acta 2006 0.97
66 HIV-protease inhibitors block the enzymatic activity of purified Ste24p. Biochem Biophys Res Commun 2008 0.97
67 Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Mol Cell Biol 2009 0.97
68 Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. PLoS One 2007 0.95
69 Are B-type lamins essential in all mammalian cells? Nucleus 2011 0.95
70 Understanding the roles of nuclear A- and B-type lamins in brain development. J Biol Chem 2012 0.93
71 Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arterioscler Thromb Vasc Biol 2010 0.93
72 Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proc Natl Acad Sci U S A 2012 0.92
73 PCSK9 function and physiology. J Lipid Res 2008 0.92
74 Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models. Curr Drug Targets 2008 0.92
75 Modulation of LMNA splicing as a strategy to treat prelamin A diseases. J Clin Invest 2016 0.90
76 Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. J Lipid Res 2012 0.88
77 Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1. Hum Mol Genet 2012 0.87
78 Targeting protein prenylation in progeria. Sci Transl Med 2013 0.85
79 Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases. J Lipid Res 2011 0.85
80 Genetic analyses of the role of RCE1 in RAS membrane association and transformation. Methods Enzymol 2008 0.83
81 Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res 2012 0.83
82 Nuclear lamins in the brain - new insights into function and regulation. Mol Neurobiol 2012 0.82
83 Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. J Lipid Res 2008 0.80
84 Lowering plasma cholesterol by raising LDL receptors--revisited. N Engl J Med 2012 0.80
85 New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome. Hum Mol Genet 2013 0.78
86 LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells. J Lipid Res 2006 0.76
87 Do lamin B1 and lamin B2 have redundant functions? Nucleus 2014 0.75