Published in Int J Cancer on June 19, 1992
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J (1998) 2.84
Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin Microbiol Rev (1999) 2.69
Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J (2000) 2.13
Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell Stress Chaperones (2010) 1.69
A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity. Cell Stress Chaperones (2001) 1.52
Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity. Invest New Drugs (1999) 1.46
Characterization of celastrol to inhibit hsp90 and cdc37 interaction. J Biol Chem (2009) 1.45
Hsp90: A New Player in DNA Repair? Biomolecules (2015) 1.45
Heat shock cognate protein 70 is involved in rotavirus cell entry. J Virol (2002) 1.37
The anti-inflammatory mechanisms of Hsp70. Front Immunol (2012) 1.31
To fold or not to fold: modulation and consequences of Hsp90 inhibition. Future Med Chem (2009) 1.29
Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients. Cell Stress Chaperones (2000) 1.28
Radiation, inflammation, and immune responses in cancer. Front Oncol (2012) 1.25
Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. Proc Natl Acad Sci U S A (2010) 1.21
Do heat shock proteins have a role in breast cancer? Br J Cancer (1996) 1.17
Chaperonin 60 unfolds its secrets of cellular communication. Cell Stress Chaperones (2002) 1.14
Secreted heat shock protein-90 (Hsp90) in wound healing and cancer. Biochim Biophys Acta (2011) 1.13
Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer. Br J Cancer (1998) 1.10
Oolemmal proteomics--identification of highly abundant heat shock proteins and molecular chaperones in the mature mouse egg and their localization on the plasma membrane. Reprod Biol Endocrinol (2003) 1.08
Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. Neoplasia (2012) 1.04
Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin. Br J Cancer (2009) 1.02
Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies. Cell Stress Chaperones (2010) 1.02
Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A. BMC Bioinformatics (2011) 0.97
In vivo imaging of CT26 mouse tumours by using cmHsp70.1 monoclonal antibody. J Cell Mol Med (2011) 0.97
Chaperone proteins and brain tumors: potential targets and possible therapeutics. Neuro Oncol (2005) 0.97
Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat shock protein 70 (Hsp70)-peptide-activated, CD94 positive natural killer cells. Cell Stress Chaperones (2002) 0.96
Interleukin 6 activates heat-shock protein 90 beta gene expression. Biochem J (1997) 0.96
Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma. Cell Stress Chaperones (2001) 0.96
Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors. Am J Physiol Gastrointest Liver Physiol (2011) 0.95
A randomized phase II study of SRL172 (Mycobacterium vaccae) combined with chemotherapy in patients with advanced inoperable non-small-cell lung cancer and mesothelioma. Br J Cancer (2000) 0.92
Molecular biology of head and neck cancer: risks and pathways. Hematol Oncol Clin North Am (2008) 0.91
Evolving therapies and FAK inhibitors for the treatment of cancer. Anticancer Agents Med Chem (2010) 0.90
Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates. J Med Chem (2006) 0.90
The Hsp90 chaperone complex A potential target for cancer therapy? World J Gastroenterol (1999) 0.90
HLA-derived peptides which inhibit T cell function bind to members of the heat-shock protein 70 family. J Exp Med (1996) 0.90
Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally. Int Rev Cell Mol Biol (2013) 0.90
Silencing heat shock protein 27 decreases metastatic behavior of human head and neck squamous cell cancer cells in vitro. Mol Pharm (2010) 0.90
Structural determination of three different series of compounds as Hsp90 inhibitors using 3D-QSAR modeling, molecular docking and molecular dynamics methods. Int J Mol Sci (2011) 0.90
Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer. Cell Death Dis (2015) 0.89
Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage. Nucleic Acids Res (2006) 0.88
Heat shock protein 70 and glycoprotein 96 are differentially expressed on the surface of malignant and nonmalignant breast cells. Cell Stress Chaperones (2006) 0.88
Heat-shock protein expression on the membrane of T cells undergoing apoptosis. Immunology (1996) 0.88
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax. Mol Cancer Ther (2013) 0.87
Heat shock and arsenite induce expression of the nonclassical class I histocompatibility HLA-G gene in tumor cell lines. Cell Stress Chaperones (2000) 0.87
VIP-grafted sterically stabilized phospholipid nanomicellar 17-allylamino-17-demethoxy geldanamycin: a novel targeted nanomedicine for breast cancer. Int J Pharm (2008) 0.87
Split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions. J Biol Chem (2010) 0.86
Extracellular heat shock proteins: a new location, a new function. Shock (2013) 0.85
Inhibition of Hsp90 and 70 sensitizes melanoma cells to hyperthermia using ferromagnetic particles with a low Curie temperature. Int J Clin Oncol (2013) 0.85
Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif. PLoS One (2012) 0.85
Differential heat shock protein localization in chronic lymphocytic leukemia. J Leukoc Biol (2009) 0.84
Surface expression of Hsp70B' in response to proteasome inhibition in human colon cells. Cell Stress Chaperones (2008) 0.84
Monoclonal antibody to novel cell surface epitope on Hsc70 promotes morphogenesis of bile ducts in newborn rat liver. Cell Stress Chaperones (2009) 0.82
Significant correlation between expression level of HSP gp96 and progression of hepatitis B virus induced diseases. World J Gastroenterol (2004) 0.82
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer. Cancers (Basel) (2014) 0.82
Role of membrane Hsp70 in radiation sensitivity of tumor cells. Radiat Oncol (2015) 0.81
Roles of heat shock proteins and gamma delta T cells in inflammation. Am J Respir Cell Mol Biol (2008) 0.81
Mechanisms of Mycotoxin-induced Dermal Toxicity and Tumorigenesis Through Oxidative Stress-related Pathways. J Toxicol Pathol (2014) 0.81
Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells. Cell Stress Chaperones (2014) 0.80
Preclinical evaluation of radiosensitizing activity of Pluronic block copolymers. Int J Radiat Biol (2013) 0.79
Prognostic significance of heat shock protein 70 (HSP70) in patients with oral cancer. Head Neck Oncol (2011) 0.79
Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery. J Cancer Prev (2015) 0.78
Monitoring the induction of heat shock factor 1/heat shock protein 70 expression following 17-allylamino-demethoxygeldanamycin treatment by positron emission tomography and optical reporter gene imaging. Mol Imaging (2012) 0.78
HSP70 expression in dentigerous cyst, odontogenic keratocyst, and ameloblastoma. Oral Maxillofac Surg (2015) 0.78
Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines. Front Oncol (2015) 0.77
Blind SELEX Approach Identifies RNA Aptamer that Regulate EMT and Inhibit Metastasis. Mol Cancer Res (2017) 0.76
Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer. J Breast Cancer (2015) 0.75
Screening of multiple myeloma by polyclonal rabbit anti-human plasmacytoma cell immunoglobulin. PLoS One (2013) 0.75
Geldanamycin induces apoptosis in human gastric carcinomas by affecting multiple oncogenic kinases that have synergic effects with TNF-related apoptosis-inducing ligand. Oncol Lett (2015) 0.75
Stress-response (heat-shock) protein 90 expression in tumors of the central nervous system: an immunohistochemical study. Acta Neuropathol (1995) 0.75
Glucocorticoid Receptor-Targeted Liposomal Codelivery of Lipophilic Drug and Anti-Hsp90 Gene: Strategy to Induce Drug-Sensitivity, EMT-Reversal, and Reduced Malignancy in Aggressive Tumors. Mol Pharm (2016) 0.75
Use of ultraviolet-light irradiated multiple myeloma cells as immunogens to generate tumor-specific cytolytic T lymphocytes. J Immune Based Ther Vaccines (2008) 0.75
Degradable Cross-Linked Nanoassemblies as Drug Carriers for Heat Shock Protein 90 Inhibitor 17-N-Allylamino-17-demethoxy-geldanamycin. Pharmaceuticals (Basel) (2011) 0.75
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90. Nat Commun (2017) 0.75
Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cells. Redox Biol (2017) 0.75
Heat shock and proinflammatory stressors induce differential localization of heat shock proteins in human monocytes. Inflammation (1997) 0.75
Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. J Immunol (1998) 2.27
Processing of engulfed apoptotic bodies yields T cell epitopes. J Immunol (1997) 1.97
HIV-I Tat: a polypeptide for all seasons. Immunol Today (1998) 1.92
Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen-presenting cells, and cytokines. J Immunol (1999) 1.82
Central nervous system involvement in systemic lupus erythematosus patients without overt neuropsychiatric manifestations. Lupus (1999) 1.70
The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells. Blood (2000) 1.58
The selective engulfment of apoptotic bodies by dendritic cells is mediated by the alpha(v)beta3 integrin and requires intracellular and extracellular calcium. Eur J Immunol (1997) 1.50
Killing of laminin receptor-positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+) t-cell receptors. J Natl Cancer Inst (1996) 1.47
CD8(+) T lymphocytes induce polarized exocytosis of secretory lysosomes by dendritic cells with release of interleukin-1beta and cathepsin D. Blood (2001) 1.31
Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes. J Cell Biol (1992) 1.28
Phenotypic and functional characterization of recombinant interleukin 2 (rIL 2)-induced activated killer cells: analysis at the population and clonal levels. J Immunol (1987) 1.27
NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46. Eur J Immunol (2001) 1.25
CD3+ WT31- peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the alpha/beta heterodimer. Eur J Immunol (1987) 1.23
Control of interleukin-18 secretion by dendritic cells: role of calcium influxes. FEBS Lett (2000) 1.22
Apoptotic cell clearance in systemic lupus erythematosus. I. Opsonization by antiphospholipid antibodies. Arthritis Rheum (1998) 1.17
Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate. Leukemia (2009) 1.14
Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol (1998) 1.11
Selective lysis of the autologous tumor by delta TCS1+ gamma/delta+ tumor-infiltrating lymphocytes from human lung carcinomas. Eur J Immunol (1990) 1.09
Roles of tumor necrosis factor p55 and p75 receptors in TNF-alpha-induced vascular permeability. Am J Physiol Cell Physiol (2001) 1.06
p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor. Eur J Immunol (1998) 1.05
NKRP1A molecule is involved in transendothelial migration of CD4+ human T lymphocytes. Immunol Lett (1997) 1.04
Remnants of suicidal cells fostering systemic autoaggression. Apoptosis in the origin and maintenance of autoimmunity. Arthritis Rheum (2000) 1.03
IL-12-mediated NKRP1A up-regulation and consequent enhancement of endothelial transmigration of V delta 2+ TCR gamma delta+ T lymphocytes from healthy donors and multiple sclerosis patients. J Immunol (1999) 1.00
Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 Tat. J Biol Chem (1998) 1.00
Interleukin-18 synthesis and secretion by dendritic cells are modulated by interaction with antigen-specific T cells. J Leukoc Biol (1999) 0.99
Secretion of bioactive interleukin-1beta by dendritic cells is modulated by interaction with antigen specific T cells. Blood (2000) 0.98
Dendritic cells preferentially internalize apoptotic cells opsonized by anti-beta2-glycoprotein I antibodies. J Autoimmun (1998) 0.98
The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function. FEBS Lett (1995) 0.96
Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration. Eur J Immunol (1997) 0.95
Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes. J Biol Chem (1997) 0.95
Apoptotic cell clearance in systemic lupus erythematosus. II. Role of beta2-glycoprotein I. Arthritis Rheum (1998) 0.94
Expression and function of NKRP1A molecule on human monocytes and dendritic cells. Eur J Immunol (1997) 0.94
Mycobacterium tuberculosis exploits the CD95/CD95 ligand system of gammadelta T cells to cause apoptosis. Eur J Immunol (1998) 0.93
Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils. J Biol Chem (1998) 0.93
Primary sternal osteomyelitis by Aspergillus fumigatus. Br J Rheumatol (1994) 0.92
CD14+ CD34+ peripheral blood mononuclear cells migrate across endothelium and give rise to immunostimulatory dendritic cells. J Immunol (1998) 0.92
In vitro priming of cytotoxic T lymphocytes against poorly immunogenic epitopes by engineered antigen-presenting cells. Eur J Immunol (1994) 0.91
uPA/uPAR system is active in immature dendritic cells derived from CD14+CD34+ precursors and is down-regulated upon maturation. J Immunol (2000) 0.91
Daudi lymphoma killing triggers the programmed death of cytotoxic V gamma 9/V delta 2 T lymphocytes. J Immunol (1995) 0.90
Analysis of signal transducing mechanisms in CD3+ CD4- CD8- cells expressing the putative T cell receptor gamma gene product. J Immunol (1987) 0.90
A novel 120-kD surface antigen expressed by a subset of human lymphocytes. Evidence that lymphokine-activated killer cells express this molecule and use it in their effector function. J Exp Med (1987) 0.89
Prognostic factors for survival in metastatic renal cell carcinoma: retrospective analysis from 109 consecutive patients. Eur Urol (1997) 0.89
Identification of a new surface molecule expressed by human LGL and LAK cells production of a specific monoclonal antibody and comparison with other NK/LAK markers. Cell Immunol (1989) 0.88
Co-expression of B7-1 and ICAM-1 on tumors is required for rejection and the establishment of a memory response. Eur J Immunol (1995) 0.87
Engagement of CD30 shapes the secretion of cytokines by human gamma delta T cells. Eur J Immunol (2000) 0.86
A functional monoclonal antibody recognizing the human alpha 1-integrin I-domain. Tissue Antigens (1996) 0.86
CD31-triggered rearrangement of the actin cytoskeleton in human natural killer cells. Eur J Immunol (1996) 0.85
Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias. Eur J Immunol (2000) 0.84
Reduction of brain metastasis following immunotherapy with interleukin-2 for stage IV renal cell cancer. Acta Oncol (1997) 0.84
Chronic bilateral dacryo-adenitis in identical twins: a possible incomplete form of Sjögren syndrome. Eur J Pediatr (1991) 0.84
Gammadelta T lymphocytes producing IFNgamma and IL-17 in response to Candida albicans or mycobacterial antigens: possible implications for acute and chronic inflammation. Curr Med Chem (2009) 0.84
Major histocompatibility complex class I restricted cytotoxic T cells specific for natural melanoma peptides recognize unidentified shared melanoma antigen(s). Cancer Res (1999) 0.83
ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage. Leukemia (2006) 0.83
Effect of corticosteroids on neutrophil function: inhibition of antibody-dependent cell mediated cytotoxicity (ADCC). J Immunopharmacol (1983) 0.83
Human melanoma cells transfected with the B7-2 co-stimulatory molecule induce tumor-specific CD8+ cytotoxic T lymphocytes in vitro. Hum Gene Ther (1998) 0.83
B7.1 expression on tumor cells circumvents the need of professional antigen presentation for in vitro propagation of cytotoxic T cell lines. Cancer Res (1996) 0.83
Constitutive expression of the heat shock protein 72 kDa in human melanoma cells. Cancer Lett (1994) 0.83
NK cell activity and monocyte dysfunctions in a patient with common variable hypogammaglobulinemia. J Clin Lab Immunol (1988) 0.82
Tumor necrosis factor alpha-induced vascular leakage involves PECAM1 phosphorylation. Cancer Res (1996) 0.82
Drug-induced in vitro inhibition of neutrophil-endothelial cell adhesion. Br J Pharmacol (1996) 0.82
Distinct pattern of HSP72 and monomeric laminin receptor expression in human lung cancers infiltrated by gamma/delta T lymphocytes. Int J Cancer (1994) 0.81
Lymphocyte-endothelial cell adhesion molecules at the primary tumor site in human lung and renal cell carcinomas. J Natl Cancer Inst (1993) 0.81
In vivo administration of GM-CSF promotes the clearance of apoptotic cells: effects on monocytes and polymorphonuclear leukocytes. J Leukoc Biol (2000) 0.81
Dissection of lymphocyte function-associated antigen 1-dependent adhesion and signal transduction in human natural killer cells shown by the use of cholera or pertussis toxin. Eur J Immunol (1996) 0.80
Tumor-driven matrix invasion by infiltrating lymphocytes: involvement of the alpha1 integrin I-domain. Eur J Immunol (1998) 0.80
Anti-phospholipid-antibody syndrome associated with peripheral T-cell lymphoma. Am J Hematol (1997) 0.80
Migratory pathways of gammadelta T cells and response to CXCR3 and CXCR4 ligands: adhesion molecules involved and implications for multiple sclerosis pathogenesis. Ann N Y Acad Sci (2007) 0.80
Effect of cyclosporine and aminophylline on streptozotocin-induced diabetes in rats. Immunol Lett (1985) 0.80
Modulating mesenchymal stromal cell function with cholesterol synthesis inhibitors. Curr Med Chem (2011) 0.79
Blockade of the Fas-triggered intracellular signaling pathway in human melanomas is circumvented by cytotoxic lymphocytes. Int J Cancer (1999) 0.79
Theophylline induced non specific suppressor activity in human peripheral blood lymphocytes. J Immunopharmacol (1985) 0.79
Generation of nitric oxide by the inducible nitric oxide synthase protects gamma delta T cells from Mycobacterium tuberculosis-induced apoptosis. J Immunol (1999) 0.79
Rejection of a nonimmunogenic melanoma by vaccination with natural melanoma peptides on engineered antigen-presenting cells. J Immunol (1997) 0.79
Particulate naturally processed peptides prime a cytotoxic response against human melanoma in vitro. Cancer Res (1996) 0.79
CD95 engagement releases calcium from intracellular stores of long term activated, apoptosis-prone gammadelta T cells. J Immunol (1996) 0.79
Quantitative cytometry of MHC class I digestion from living cells. Cytometry (1997) 0.78
Inducible nitric oxide synthase modulates fibronectin production in the EA.hy926 cell line and cultured human umbilical vein endothelial cells. J Cardiovasc Pharmacol (1994) 0.78
In vitro effects of halothane on lymphocytes. Eur J Anaesthesiol (1986) 0.78
Circulating immune complexes in patients with lung neoplasms. Ric Clin Lab (1981) 0.78
In vivo apoptosis of CD8(+) lymphocytes in acute myeloid leukemia patients: involvement of soluble HLA-I and Fas ligand. Leukemia (2006) 0.78
Spontaneous "in vitro" variations of theophylline sensitivity in human peripheral blood lymphocytes. Boll Ist Sieroter Milan (1983) 0.78
Prolonged survival of experimental heart transplantation induced by theophylline. Immunol Lett (1983) 0.78
Impaired left ventricular filling rate induced by treatment with recombinant interleukin 2 for advanced cancer. Br Heart J (1994) 0.78
Inhibition of caspases maintains the antineoplastic function of gammadelta T cells repeatedly challenged with lymphoma cells. Cancer Res (2001) 0.77
Expression of Fc and complement receptors on T lymphocytes activated in vitro by phytohaemagglutinin (PHA). Immunology (1977) 0.77