Phospholipases C and D in mitogenic signal transduction.

Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. Biochem J (1996) 0.94

Phospholipase D activation by P2Z-purinoceptor agonists in human lymphocytes is dependent on bivalent cation influx. Biochem J (1996) 0.92

Epidermal growth factor stimulates distinct diradylglycerol species generation in Swiss 3T3 fibroblasts: evidence for a potential phosphatidylcholine-specific phospholipase C-catalysed pathway. Biochem J (1994) 0.84

Inactive membrane protein kinase Cs: a possible target for receptor signalling. Biochem J (1994) 0.82

Dependence of stimulus-transcription coupling on phospholipase D in agonist-stimulated pituitary cells. Mol Biol Cell (1995) 0.81

Cell signalling in pulmonary vascular cells: do not shoot the messenger! Thorax (1996) 0.78

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production. Nature (1986) 3.41

Activation of two signal-transduction systems in hepatocytes by glucagon. Nature (1986) 2.21

Development of a novel, Ins(1,4,5)P3-specific binding assay. Its use to determine the intracellular concentration of Ins(1,4,5)P3 in unstimulated and vasopressin-stimulated rat hepatocytes. Cell Signal (1989) 2.07

CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator. Oncogene (1996) 1.85

The fusion of myoblasts. Biochem J (1985) 1.80

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers? Trends Biochem Sci (1998) 1.69

Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism. Biochem J (1989) 1.66

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation. Curr Biol (1998) 1.62

Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem (1995) 1.58

Transmitter-like action of ATP on patched membranes of cultured myoblasts and myotubes. Nature (1983) 1.58

Stimulation of actin stress fibre formation mediated by activation of phospholipase D. Curr Biol (1996) 1.51

Differences in the regulation of endothelin-1- and lysophosphatidic-acid-stimulated Ins(1,4,5)P3 formation in rat-1 fibroblasts. Biochem J (1991) 1.37

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems. Oncogene (1988) 1.37

Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-specific PH domain. Curr Biol (2000) 1.30

Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. FASEB J (1999) 1.30

Mass measurement of inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol in bombesin-stimulated Swiss 3T3 mouse fibroblasts. Biochem J (1990) 1.29

SPO14 separation-of-function mutations define unique roles for phospholipase D in secretion and cellular differentiation in Saccharomyces cerevisiae. Genetics (2001) 1.22

Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions. Phospholipase D-derived diacylglycerol does not activate protein kinase C in porcine aortic endothelial cells. J Biol Chem (1997) 1.22

Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. EMBO J (2000) 1.16

Phospholipase D1b and D2a generate structurally identical phosphatidic acid species in mammalian cells. Biochem J (2001) 1.16

Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins. Biochem J (1988) 1.13

Widespread distribution of Gq alpha/G11 alpha detected immunologically by an antipeptide antiserum directed against the predicted C-terminal decapeptide. FEBS Lett (1991) 1.12

Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation. Blood (2001) 1.10

Regulation of bombesin-stimulated inositol 1,4,5-trisphosphate generation in Swiss 3T3 fibroblasts by a guanine-nucleotide-binding protein. Biochem J (1990) 1.08

Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31. FEBS Lett (1999) 1.07

Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts. Biochem J (1990) 1.06

The regulation of phospholipase D activity and its role in sn-1,2-diradylglycerol formation in bombesin- and phorbol 12-myristate 13-acetate-stimulated Swiss 3T3 cells. Biochem J (1991) 1.05

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D. Biochem J (1991) 1.05

The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism. Biochem J (1987) 1.04

Hydrolysis of phosphatidylcholine by phospholipase D is a common response to mitogens which stimulate inositol lipid hydrolysis in Swiss 3T3 fibroblasts. Biochim Biophys Acta (1991) 1.04

The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages. Biochem Biophys Res Commun (1992) 1.02

Diacylglycerol kinase epsilon, but not zeta, selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo. J Biol Chem (1999) 1.01

Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs). Biochem J (1989) 1.00

The p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complex. Biochem J (2001) 0.99

Inositol phospholipid metabolism and myoblast fusion. Biochem J (1983) 0.99

Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins. J Biol Chem (1992) 0.98

Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation. J Immunol (1996) 0.96

Bombesin stimulates distinct time-dependent changes in the sn-1,2-diradylglycerol molecular species profile from Swiss 3T3 fibroblasts as analysed by 3,5-dinitrobenzoyl derivatization and h.p.l.c. separation. Biochem J (1993) 0.96

The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding. Biochem J (1989) 0.95

Vasopressin-stimulated [3H]-inositol phosphate and [3H]-phosphatidylbutanol accumulation in A10 vascular smooth muscle cells. Br J Pharmacol (1992) 0.94

Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis. Biochem J (1992) 0.94

Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells. J Cell Sci (2000) 0.94

Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol. J Biol Chem (1999) 0.93

Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines. Int J Cancer (1992) 0.93

Regulation by hypoxia of endothelin-1-stimulated phospholipase D activity in sheep pulmonary artery cultured smooth muscle cells. Br J Pharmacol (1994) 0.93

The Ins(1,4,5)P3 binding site of bovine adrenocortical microsomes: function and regulation. Biochem J (1989) 0.93

Adipsin and the glucose transporter GLUT4 traffic to the cell surface via independent pathways in adipocytes. Traffic (2000) 0.92

Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N-ras proto-oncogene. Biochem J (1989) 0.91

Second messengers. Sphingolipid signalling. Curr Biol (1994) 0.91

Insulin and platelet-derived growth factor acutely stimulate glucose transport in 3T3-L1 fibroblasts independently of protein kinase C. Biochim Biophys Acta (1993) 0.90

Activation of phospholipase D and phosphatidylinositol 4-phosphate 5-kinase in HL60 membranes is mediated by endogenous Arf but not Rho. J Biol Chem (1996) 0.90

Accurate measurement of sn-1,2-diradylglycerol mass in cell lipid extracts. Biochem J (1991) 0.89

Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells. J Biol Chem (1992) 0.89

Stimulated phosphatidylcholine hydrolysis as a signal transduction pathway in mitogenesis. Cell Signal (1991) 0.89

Characterization of the regulation of phospholipase D activity in the detergent-insoluble fraction of HL60 cells by protein kinase C and small G-proteins. Biochem J (1999) 0.88

Phosphatidylinositol 3'-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells. J Biol Chem (1997) 0.88

Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon. Biochem J (1989) 0.86

Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells. Lab Invest (1996) 0.86

The breakdown of phosphatidylinositol in myoblasts stimulated to fuse by the addition of Ca2+. Biochem J (1982) 0.86

De novo synthesis of glucokinase in hepatocytes isolated from neonatal rats. FEBS Lett (1980) 0.86

The control of glucose 1,6-bisphosphate by developmental state and hormonal stimulation in cultured muscle tissue. Biochem J (1982) 0.85

Activation of inositol phospholipid breakdown by prostaglandin F2 alpha without any stimulation of proliferation in quiescent NIH-3T3 fibroblasts. Biochem J (1990) 0.85

L6 skeletal muscle cells have functional V1-vasopressin receptors coupled to stimulated inositol phospholipid metabolism. FEBS Lett (1987) 0.84

Assessing the value of matrix metalloproteinase 9 (MMP9) in improving the appropriateness of referrals for colorectal cancer. Br J Cancer (2013) 0.84

Epidermal growth factor stimulates distinct diradylglycerol species generation in Swiss 3T3 fibroblasts: evidence for a potential phosphatidylcholine-specific phospholipase C-catalysed pathway. Biochem J (1994) 0.84

Prostaglandins and cyclic AMP stimulate creatine kinase synthesis but not fusion in cultured embryonic chick muscle cells. Biochim Biophys Acta (1984) 0.82

Serum matrix metalloproteinase 9 and colorectal neoplasia: a community-based evaluation of a potential diagnostic test. Br J Cancer (2012) 0.82

Homologous desensitization of bombesin-stimulated Ins(1,4,5)P3 production in Swiss 3T3 fibroblasts. Biochem Soc Trans (1991) 0.82

Rapid desensitization and resensitization of bombesin-stimulated phospholipase D activity in Swiss 3T3 cells. Biochem J (1994) 0.81

Rapid desensitization of vasopressin-stimulated phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis questions the role of these pathways in sustained diacylglycerol formation in A10 vascular-smooth-muscle cells. Biochem J (1992) 0.81

Thyroid hormones and the precocious induction of hepatic glucokinase in the neonatal rat. Eur J Biochem (1979) 0.81

Mass measurement of inositol phosphates. Biochim Biophys Acta (1989) 0.81

G-proteins and second messengers in mitogenesis. Prog Growth Factor Res (1989) 0.80

Angiotensin II enhances responses to endothelin-1 in bovine bronchial smooth muscle. Pulm Pharmacol (1994) 0.80

Myoblast fusion and inositol phospholipid breakdown: causal relationship or coincidence? Ciba Found Symp (1984) 0.80

The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts. Biochem J (1995) 0.79

Mechanical and biochemical responses to endothelin-1 and endothelin-3 in bovine bronchial smooth muscle. Br J Pharmacol (1994) 0.79

Antagonistic roles for phospholipase D activities in B cell signaling: while the antigen receptors transduce mitogenic signals via a novel phospholipase D activity, phosphatidylcholine-phospholipase D mediates antiproliferative signals. J Immunol (1998) 0.78

Glucagon stimulates adenylate cyclase through GR2 glucagon receptors: a process which can be attenuated by glucagon stimulating inositol phospholipid metabolism through GR1 glucagon receptors. Biochem Soc Trans (1987) 0.78

The co-mitogenic combination of transforming growth factor beta 1 and bombesin protects protein kinase C-delta from late-phase down-regulation, despite synergy in diacylglycerol accumulation. Biochem J (1996) 0.78

Mechanical and biochemical responses to endothelin-1 and endothelin-3 in human bronchi. Eur J Pharmacol (1994) 0.78

The separate roles of glucose and insulin in the induction of glucokinase in hepatocytes isolated from neonatal rats. Biochem J (1981) 0.78

Endothelin stimulates phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis in Rat-1 cells. Biochem Soc Trans (1990) 0.78

The role of N-ras p21 in the coupling of growth factor receptors to inositol phospholipid turnover. Biochem Soc Trans (1987) 0.78

The control of glucose 1,6-bisphosphatase by Ca2+ and calmodulin. Biochem J (1982) 0.77

Induction of glucokinase in vitro in hepatocytes from neonatal rats [proceedings]. Biochem Soc Trans (1980) 0.77

Differences in the coupling of ET-1 and LPA receptors in Ins(1,4,5)P3 formation in Rat-1 fibroblasts. Biochem Soc Trans (1991) 0.77

Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism. Oncogene (1989) 0.77

Distinct phospholipase C-regulated signalling pathways in Swiss 3T3 fibroblasts induce the rapid generation of the same polyunsaturated diacylglycerols. FEBS Lett (1998) 0.77

Stimulated inositol phospholipid breakdown and myoblast fusion. Biochem Soc Trans (1986) 0.77

Desensitization of prostaglandin F2 alpha-stimulated inositol phosphate generation in NIH-3T3 fibroblasts transformed by overexpression of normal c-Ha-ras-1, c-Ki-ras-2 and c-N-ras genes. Biochem J (1990) 0.77

Regulation of 'signalling diacylglycerol' in cells: the importance of diacylglycerol kinase. Biochem Soc Trans (1996) 0.77

Purification and characterization of sn-1-stearoyl-2-arachidonoylglycerol kinase from pig testes. Biochem J (1997) 0.76

The effects of p21N-ras expression in NIH-3T3 cells upon cyclic AMP metabolism. Biochim Biophys Acta (1989) 0.76

3T3-L1 adipocytes express two isoforms of phospholipase D in distinct subcellular compartments. Biochem Biophys Res Commun (1999) 0.76

Differential expression of human phospholipase D genes. Biochem Soc Trans (1997) 0.76

Heterologous desensitization of bombesin- and vasopressin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts. FEBS Lett (1995) 0.75

Epidermal growth factor stimulates phospholipase D activity in the absence of inositol lipid hydrolysis in Swiss 3T3 cells. Biochem Soc Trans (1991) 0.75

The regulation of agonist-stimulated phospholipase D activity in Swiss 3T3 fibroblasts. Biochem Soc Trans (1993) 0.75