Published in J Gen Physiol on April 01, 1977
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol (1977) 12.38
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons. Biophys J (1978) 4.08
Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle. Biophys J (1977) 3.04
Block of sodium conductance and gating current in squid giant axons poisoned with quaternary strychnine. Biophys J (1979) 2.30
Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J Gen Physiol (1985) 2.04
Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel. Proc Natl Acad Sci U S A (1995) 1.83
Quinine blocks specific gap junction channel subtypes. Proc Natl Acad Sci U S A (2001) 1.67
Pharmacological targeting of long QT mutant sodium channels. J Clin Invest (1997) 1.55
MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall. J Bacteriol (2009) 1.49
Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation. J Gen Physiol (1987) 1.42
Dissecting lidocaine action: diethylamide and phenol mimic separate modes of lidocaine block of sodium channels from heart and skeletal muscle. Biophys J (1993) 1.40
Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues. J Gen Physiol (2003) 1.37
Permeant ion effects on the gating kinetics of the type L potassium channel in mouse lymphocytes. J Gen Physiol (1991) 1.34
Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. J Physiol (2007) 1.34
Fast lidocaine block of cardiac and skeletal muscle sodium channels: one site with two routes of access. Biophys J (1993) 1.26
Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel. Biophys J (1993) 1.21
Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations. J Gen Physiol (2002) 1.17
A quantitative model of amphetamine action on the 5-HT transporter. Br J Pharmacol (2014) 1.11
Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence. Biophys J (1990) 1.07
Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine. Biophys J (1990) 1.07
The hitchhiker's guide to the voltage-gated sodium channel galaxy. J Gen Physiol (2016) 1.03
Influence of pHo on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor. J Gen Physiol (1989) 1.01
Pavlovian conditioning in the rabbit during inactivation of the interpositus nucleus. J Physiol (1991) 1.01
Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization. Biophys J (2007) 1.00
Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. Br J Pharmacol (2011) 1.00
Sites of action of procaine at the motor end-plate. J Physiol (1983) 0.99
Na(+)-H+ antiport detected through hydrogen ion currents in rat alveolar epithelial cells and human neutrophils. J Gen Physiol (1994) 0.97
Tonic and phasic block of neuronal sodium currents by 5-hydroxyhexano-2',6'-xylide, a neutral lidocaine homologue. J Gen Physiol (1989) 0.94
Extracellular site for econazole-mediated block of Ca2+ release-activated Ca2+ current (Icrac) in T lymphocytes. Br J Pharmacol (1996) 0.93
Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve. Anesthesiology (2008) 0.92
Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart. J Mol Biol (2014) 0.91
Block of voltage-dependent sodium currents by the substance P receptor antagonist (+/-)-CP-96,345 in neurones cultured from rat cortex. Br J Pharmacol (1993) 0.90
Dual actions of procainamide on batrachotoxin-activated sodium channels: open channel block and prevention of inactivation. Biophys J (1993) 0.89
Conotoxins as sensors of local pH and electrostatic potential in the outer vestibule of the sodium channel. J Gen Physiol (2003) 0.87
Functional mapping of the neural circuitry of rat maternal motivation: effects of site-specific transient neural inactivation. J Neuroendocrinol (2011) 0.87
Nonselective suppression of voltage-gated currents by odorants in the newt olfactory receptor cells. J Gen Physiol (1997) 0.86
The activation gate of the sodium channel controls blockade and deblockade by disopyramide in rabbit Purkinje fibres. Br J Pharmacol (1989) 0.86
Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine. Br J Pharmacol (1994) 0.85
The changing role of the medial preoptic area in the regulation of maternal behavior across the postpartum period: facilitation followed by inhibition. Behav Brain Res (2009) 0.84
The effects of local anaesthetics on the electrical and mechanical activity of the guinea-pig ureter. Br J Pharmacol (1986) 0.84
The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma. Biochemistry (2015) 0.83
The medial preoptic area is necessary for motivated choice of pup- over cocaine-associated environments by early postpartum rats. Neuroscience (2010) 0.83
Differential effects of voltage-dependent inactivation and local anesthetics on kinetic phases of Ca2+ release in frog skeletal muscle. Biophys J (2003) 0.82
State-Dependent Inhibition of Sodium Channels by Local Anesthetics: A 40-Year Evolution. Biochem (Mosc) Suppl Ser A Membr Cell Biol (2012) 0.82
The interaction of amine local anaesthetics with muscarinic receptors. Br J Pharmacol (1980) 0.82
Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide. Br J Pharmacol (2010) 0.82
Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. J Gen Physiol (2016) 0.81
Classification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp study. PLoS One (2010) 0.81
Locating the route of entry and binding sites of benzocaine and phenytoin in a bacterial voltage gated sodium channel. PLoS Comput Biol (2014) 0.81
Blockade by local anaesthetics of the single Ca(2+)-activated K+ channel in rat hippocampal neurones. Br J Pharmacol (1992) 0.79
Effects of propafenone on calcium current in guinea-pig ventricular myocytes. Br J Pharmacol (1993) 0.79
Effect of calcium and other divalent cations on intracellular pH regulation of frog skeletal muscle. J Physiol (1986) 0.79
High membrane permeability for melatonin. J Gen Physiol (2016) 0.78
Sidedness of carbamazepine accessibility to voltage-gated sodium channels. Mol Pharmacol (2013) 0.78
Ca(2+)-blockable, poorly selective cation channels in the apical membrane of amphibian epithelia. Tetracaine blocks the UO2(2+)-insensitive pathway. J Gen Physiol (1993) 0.78
Inhibitory action of SR33557 on L-type calcium current in single ventricular myocytes of rat. Br J Pharmacol (1995) 0.76
Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway. Front Pharmacol (2015) 0.75
A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons. Sci Rep (2016) 0.75
Membrane currents in isolated frog nerve fibre under voltage clamp conditions. J Physiol (1958) 13.59
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol (1977) 12.38
The permeability of the sodium channel to organic cations in myelinated nerve. J Gen Physiol (1971) 10.25
Effect of procaine on electrical properties of squid axon membrane. Am J Physiol (1959) 8.56
The inner quaternary ammonium ion receptor in potassium channels of the node of Ranvier. J Gen Physiol (1972) 6.55
Local anaesthetics. VI. Relation between blocking potency and penetration of a monomolecular layer of lipoids from nerves. Acta Pharmacol Toxicol (Copenh) (1954) 5.11
[Effect of tetrodotoxin and tertaethylammonium chloride on the inside of the membrane of Ranvier's node in Xenopus laevis]. Pflugers Arch (1969) 3.88
The site of action and active form of local anesthetics. II. Experiments with quaternary compounds. J Pharmacol Exp Ther (1970) 3.59
Water and nonelectrolyte permeability of lipid bilayer membranes. J Gen Physiol (1976) 2.68
Diffusion of weak acids across lipid bilayer membranes: effects of chemical reactions in the unstirred layers. Science (1973) 2.59
The site of action and active form of local anesthetics. I. Theory and pH experiments with tertiary compounds. J Pharmacol Exp Ther (1970) 2.13
On the mode of action of local anesthetics. Annu Rev Pharmacol (1966) 1.99
The membrane concentration of a local anesthetic (chlorpromazine). Biochim Biophys Acta (1969) 1.86
On the active structure of local anesthetics. J Pharmacol Exp Ther (1961) 1.75
Rate of action of tetraethylammonium ions on the duration of action potentials in single Ranvier nodes. Pflugers Arch (1971) 1.61
Local anesthetics. I. The blocking potencies of some local anesthetics and of butyl alcohol determined on peripheral nerves. Acta Pharmacol Toxicol (Copenh) (1954) 1.48
Intracellular pH, H ion flux and H ion permeability coefficient in bullfrog toe muscle. J Physiol (1972) 1.34
Site of action and active form of procaine in squid giant axons. J Pharmacol Exp Ther (1975) 1.23
Mechanism of action of local anaesthetic agents and biotoxins. Br J Anaesth (1975) 1.22
Anesthetic blocking of nerve membrane conductances by internal and external applications. J Neurobiol (1969) 1.11
The effect of the nerve sheath on the action of local anesthetics. J Pharmacol Exp Ther (1965) 1.10
Effect of a sudden change in sodium concentration on repetitively evoked action potentials of single nodes of Ranvier. Pflugers Arch (1971) 1.08
Saxitoxin and procaine act independently on separate sites of the sodium channel. Pflugers Arch (1976) 1.05
Tetraethylammonium ion inhibition of potassium conductance of the nodal membrane. Biochim Biophys Acta (1972) 0.98
The active structure of local anesthetics. J Pharmacol Exp Ther (1965) 0.96
Comparison of tertiary and quaternary amine local anesthetics in their ability to depress membrane ionic conductances. J Neurobiol (1972) 0.92
Local anesthetics: effect of pH on activity. Science (1968) 0.91
The effects of pH gradients on the action of procaine and lidocaine in intact and desheathed sciatic nerves. J Pharmacol Exp Ther (1970) 0.88
The effects of pH gradients on the uptake and distribution of C14-procaine and lidocaine in intact and desheathed sciatic nerve trunks. J Pharmacol Exp Ther (1970) 0.86
Some physiochemical properties of the racemates and the optically active isomers of two local anaesthetic compounds. Acta Pharm Suec (1971) 0.84
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol (1977) 12.38
Potassium channels as multi-ion single-file pores. J Gen Physiol (1978) 11.01
The permeability of the sodium channel to organic cations in myelinated nerve. J Gen Physiol (1971) 10.25
The selective inhibition of delayed potassium currents in nerve by tetraethylammonium ion. J Gen Physiol (1967) 10.05
Pharmacological modifications of the sodium channels of frog nerve. J Gen Physiol (1968) 9.97
Charges and potentials at the nerve surface. Divalent ions and pH. J Gen Physiol (1968) 9.73
Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH. Philos Trans R Soc Lond B Biol Sci (1975) 7.52
The inner quaternary ammonium ion receptor in potassium channels of the node of Ranvier. J Gen Physiol (1972) 6.55
Potassium channels in myelinated nerve. Selective permeability to small cations. J Gen Physiol (1973) 6.13
The permeability of the sodium channel to metal cations in myelinated nerve. J Gen Physiol (1972) 6.09
An improved vaseline gap voltage clamp for skeletal muscle fibers. J Gen Physiol (1976) 5.57
Ionic selectivity, saturation, and block in sodium channels. A four-barrier model. J Gen Physiol (1975) 5.31
The permeability of the endplate channel to organic cations in frog muscle. J Gen Physiol (1980) 5.00
GTP-binding proteins couple cardiac muscarinic receptors to a K channel. Nature (1985) 4.95
The permeability of endplate channels to monovalent and divalent metal cations. J Gen Physiol (1980) 4.72
Light scattering and birefringence changes during nerve activity. Nature (1968) 4.65
Ionic selectivity of Na and K channels of nerve membranes. Membranes (1975) 4.30
Modulation of Ca2+ channels by G-protein beta gamma subunits. Nature (1996) 3.79
Kinetic and pharmacological properties of the sodium channel of frog skeletal muscle. J Gen Physiol (1976) 3.73
Mitochondrial participation in the intracellular Ca2+ network. J Cell Biol (1997) 3.56
Analysis of the potential-dependent changes in optical retardation in the squid giant axon. J Physiol (1971) 3.50
Measurement of the conductance of the sodium channel from current fluctuations at the node of Ranvier. J Physiol (1976) 3.46
Ionic channels in nerve membranes. Prog Biophys Mol Biol (1970) 3.14
Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle. Biophys J (1977) 3.04
Common mode of action of three agents that decrease the transient change in sodium permeability in nerves. Nature (1966) 2.90
Electrical measurements on endomembranes. Science (1992) 2.55
Gating of Na channels. Inactivation modifiers discriminate among models. J Gen Physiol (1987) 2.53
Dominant role of mitochondria in clearance of large Ca2+ loads from rat adrenal chromaffin cells. Neuron (1996) 2.51
The receptor for tetrodotoxin and saxitoxin. A structural hypothesis. Biophys J (1975) 2.27
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc Natl Acad Sci U S A (1992) 2.23
Lyotropic anions. Na channel gating and Ca electrode response. J Gen Physiol (1983) 2.18
Conductance of the sodium channel in myelinated nerve fibres with modified sodium inactivation. J Physiol (1976) 2.15
Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current. J Neurosci (2000) 2.15
Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc Natl Acad Sci U S A (1997) 2.10
Voltage-gated ion channels and electrical excitability. Neuron (1998) 2.03
Block of endplate channels by permeant cations in frog skeletal muscle. J Gen Physiol (1981) 2.00
A diffusible second messenger mediates one of the pathways coupling receptors to calcium channels in rat sympathetic neurons. Neuron (1991) 1.96
Ionic channels of the inner segment of tiger salamander cone photoreceptors. J Gen Physiol (1989) 1.95
Intracellular Ca2+ buffers disrupt muscarinic suppression of Ca2+ current and M current in rat sympathetic neurons. Proc Natl Acad Sci U S A (1991) 1.86
Low intracellular pH and chemical agents slow inactivation gating in sodium channels of muscle. Nature (1980) 1.85
Changes in axon birefringence during the action potential. J Physiol (1970) 1.85
Climate change and the integrity of science. Science (2010) 1.80
Bradykinin inhibits M current via phospholipase C and Ca2+ release from IP3-sensitive Ca2+ stores in rat sympathetic neurons. Proc Natl Acad Sci U S A (1998) 1.74
The hydration of sodium ions crossing the nerve membrane. Proc Natl Acad Sci U S A (1971) 1.71
Light scattering and birefringence changes during activity in the electric organ of electrophorus electricus. J Physiol (1969) 1.63
Rhythmic exocytosis stimulated by GnRH-induced calcium oscillations in rat gonadotropes. Science (1993) 1.60
GnRH-induced Ca2+ oscillations and rhythmic hyperpolarizations of pituitary gonadotropes. Science (1992) 1.58
An essential ionized acid group in sodium channels. Fed Proc (1975) 1.57
Characterization of muscarinic receptor subtypes inhibiting Ca2+ current and M current in rat sympathetic neurons. Proc Natl Acad Sci U S A (1992) 1.57
Agonists that suppress M-current elicit phosphoinositide turnover and Ca2+ transients, but these events do not explain M-current suppression. Neuron (1988) 1.55
Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons. Neuron (1992) 1.53
Calcium homeostasis in identified rat gonadotrophs. J Physiol (1994) 1.51
Gating in sodium channels of nerve. Annu Rev Physiol (1976) 1.50
Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophs. Neuron (1997) 1.49
Voltage-dependent gating of veratridine-modified Na channels. J Gen Physiol (1986) 1.47
Ionic channels in excitable membranes. Current problems and biophysical approaches. Biophys J (1978) 1.45
Modulation of Ca2+ channels by PTX-sensitive G-proteins is blocked by N-ethylmaleimide in rat sympathetic neurons. J Neurosci (1994) 1.41
Mitochondrial oversight of cellular Ca2+ signaling. Curr Opin Neurobiol (1998) 1.40
CaV2.2 and CaV2.3 (N- and R-type) Ca2+ channels in depolarization-evoked entry of Ca2+ into mouse sperm. J Biol Chem (2000) 1.39
Mitochondria shape hormonally induced cytoplasmic calcium oscillations and modulate exocytosis. J Biol Chem (2000) 1.37
Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol Pharmacol (1993) 1.32
Inhibition of N- and L-type calcium channels by muscarinic receptor activation in rat sympathetic neurons. Neuron (1992) 1.29
Non-stationary fluctuations of the potassium conductance at the node of ranvier of the frog. J Physiol (1984) 1.25
5-HT3 receptor channels in dissociated rat superior cervical ganglion neurons. J Physiol (1992) 1.24
Protein kinase C is not necessary for peptide-induced suppression of M current or for desensitization of the peptide receptors. Proc Natl Acad Sci U S A (1989) 1.22
Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins. Neuron (1994) 1.21
Ca2+ clearance mechanisms in isolated rat adrenal chromaffin cells. J Physiol (1996) 1.21
Modulation by neurotransmitters of catecholamine secretion from sympathetic ganglion neurons detected by amperometry. Proc Natl Acad Sci U S A (1997) 1.20
Cyclic Ca2+ changes in intracellular stores of gonadotropes during gonadotropin-releasing hormone-stimulated Ca2+ oscillations. Proc Natl Acad Sci U S A (1994) 1.20
Veratridine modifies open sodium channels. J Gen Physiol (1988) 1.18
GABA(B)-mediated presynaptic inhibition of excitatory transmission and synaptic vesicle dynamics in cultured hippocampal neurons. Neuron (1997) 1.17
Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathways. Neuron (1993) 1.16
Slow permeation of organic cations in acetylcholine receptor channels. J Gen Physiol (1986) 1.15
Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor. J Neurosci (1998) 1.14
Ionic selectivity of Ih channels of rod photoreceptors in tiger salamanders. J Gen Physiol (1992) 1.11
A high-conductance anion channel in adult amphibian skeletal muscle. Pflugers Arch (1987) 1.10
Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca(2+) channels by using knockout mice. Proc Natl Acad Sci U S A (1999) 1.10
Intracellular responses to gonadotropin-releasing hormone in a clonal cell line of the gonadotrope lineage. Mol Endocrinol (1991) 1.06
G-protein beta-subunit specificity in the fast membrane-delimited inhibition of Ca2+ channels. J Neurosci (1998) 1.04
Voltage threshold in excitable cells depends on stimulus form. J Neurophysiol (1970) 1.03
Speed of Ca2+ channel modulation by neurotransmitters in rat sympathetic neurons. J Neurophysiol (1997) 1.00
Identification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons. Life Sci (2001) 0.99
K channels in excitable cells as multi-ion pores. Brain Res Bull (1979) 0.97
Rapid fabrication of plastic-insulated carbon-fiber electrodes for micro-amperometry. J Neurosci Methods (1999) 0.97
Loading of oxidizable transmitters into secretory vesicles permits carbon-fiber amperometry. J Neurosci (2000) 0.96
Role of voltage-gated Na+ and Ca2+ channels in gonadotropin-releasing hormone-induced membrane potential changes in identified rat gonadotropes. Endocrinology (1993) 0.95
Regulation of exocytosis by protein kinases and Ca(2+) in pancreatic duct epithelial cells. J Gen Physiol (2000) 0.95
Involvement of mitochondria in intracellular calcium sequestration by rat gonadotropes. Cell Calcium (1996) 0.94
Selective disruption by protein kinases of G-protein-mediated Ca2+ channel modulation. J Neurophysiol (1996) 0.91
Voltage clamp analysis of sodium channels in normal and scorpion toxin-resistant neuroblastoma cells. J Neurosci (1984) 0.91
The effect of surface charge on the nerve membrane on the action of tetrodotoxin and saxitoxin in frog myelinated nerve. J Physiol (1975) 0.90
State-dependent modification of sodium channels by lipid-soluble agonists. Soc Gen Physiol Ser (1987) 0.89
Protein kinase C as a signal for exocytosis. Proc Natl Acad Sci U S A (1997) 0.88
Growth hormone-releasing hexapeptide elevates intracellular calcium in rat somatotropes by two mechanisms. Endocrinology (1994) 0.86
Real-time spike detection in EEG signals using the wavelet transform and a dedicated digital signal processor card. J Neurosci Methods (1996) 0.85
Modulation of Ca2+ oscillation and apamin-sensitive, Ca2+-activated K+ current in rat gonadotropes. Pflugers Arch (1995) 0.84
Simplification of rat intubation on inclined metal plate. Adv Physiol Educ (2004) 0.84
Actions of growth-hormone-releasing hormone on rat pituitary cells: intracellular calcium and ionic currents. Pflugers Arch (1994) 0.84
Electrophysiological comparison of insecticide and alkaloid agonists of Na channels. J Gen Physiol (1987) 0.84
Modulation of high voltage-activated calcium channels by somatostatin in acutely isolated rat amygdaloid neurons. J Neurosci (1996) 0.83