| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.
|
Chem Biol
|
2003
|
2.05
|
|
2
|
Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan.
|
Cancer Res
|
2005
|
1.40
|
|
3
|
Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
|
J Mol Biol
|
2005
|
1.40
|
|
4
|
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
|
J Med Chem
|
2005
|
1.33
|
|
5
|
Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity.
|
Mol Pharmacol
|
2004
|
1.18
|
|
6
|
Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11.
|
Biochem Pharmacol
|
2010
|
1.13
|
|
7
|
Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice.
|
Cancer Chemother Pharmacol
|
2005
|
1.12
|
|
8
|
Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.
|
Mol Pharmacol
|
2006
|
0.99
|
|
9
|
Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.
|
J Med Chem
|
2009
|
0.97
|
|
10
|
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.
|
Mol Pharmacol
|
2005
|
0.96
|
|
11
|
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
|
J Nat Prod
|
2013
|
0.93
|
|
12
|
The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.
|
Chem Biol Interact
|
2005
|
0.87
|
|
13
|
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
|
Bioorg Med Chem
|
2007
|
0.86
|
|
14
|
Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.
|
J Med Chem
|
2008
|
0.83
|
|
15
|
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.
|
Bioorg Med Chem
|
2011
|
0.83
|
|
16
|
Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors.
|
Chem Biol Interact
|
2012
|
0.80
|
|
17
|
Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.
|
Mol Cancer Ther
|
2004
|
0.78
|
|
18
|
Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.
|
J Med Chem
|
2010
|
0.77
|